Patents by Inventor Neil P. Soice
Neil P. Soice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9295928Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.Type: GrantFiled: November 2, 2010Date of Patent: March 29, 2016Assignee: EMD Millipore CorporationInventors: Anthony J. DiLeo, Justin McCue, Wilson Moya, Igor Quinones-Garcia, Neil P. Soice, Volkmar Thom, Sarah Yuan
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Publication number: 20150060342Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.Type: ApplicationFiled: November 7, 2014Publication date: March 5, 2015Inventors: Anthony J. DiLeo, Justin McCue, Wilson Moya, Igor Quinones-Garcia, Neil P. Soice, Volkmar Thom, Sarah Yuan
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Patent number: 8552177Abstract: A method for making functionalized porous crosslinked polysaccharide gel coated structures used as liquid chromatography media is provided. The method includes impregnating a porous substrate with a room temperature stable aqueous polysaccharide solution containing water, 0.1% to 20% of a polysaccharide, 18% to 54% of a gel-inhibiting agent to prevent the gel from re-gelling, and 0.001% to 10% of an anionic fluorosurfactant for optimum solution coatability onto the substrate, each concentration is by total weight of the aqueous solution. Next water is evaporated from the coating, followed by exposing the dehydrated coating to a gelling agent thereby forming a porous polysaccharide gel coated substrate. Next the gel coated substrate is exposed to a crosslinking agent forming a porous crosslinked polysaccharide gel coated substrate.Type: GrantFiled: August 30, 2011Date of Patent: October 8, 2013Assignee: EMD Millipore CorporationInventors: Wilson Moya, Neil P. Soice
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Publication number: 20120288630Abstract: The present invention provides porous media or membranes having a surface coating that includes a cross-linked terpolymer which has a superior combination of properties, including heat stable biomolecule resistant adsorptive properties, resistance to strong alkaline solutions, and low levels of extractable matter. In some preferred embodiments, the porous media is a porous membrane.Type: ApplicationFiled: July 30, 2012Publication date: November 15, 2012Applicant: MILLIPORE CORPORATIONInventors: John Charkoudian, Neil P. Soice
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Publication number: 20120024787Abstract: The present invention provides porous media or membranes having a surface coating that includes a cross-linked terpolymer which has a superior combination of properties, including heat stable biomolecule resistant adsorptive properties, resistance to strong alkaline solutions, and low levels of extractable matter. In some preferred embodiments, the porous media is a porous membrane.Type: ApplicationFiled: October 5, 2011Publication date: February 2, 2012Applicant: Millipore CorporationInventors: John Charkoudian, Neil P. Soice
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Publication number: 20110311762Abstract: The present invention provides porous functionalized crosslinked polysaccharide hydrogel coated structures and methods for making the same. The methods include impregnating a porous substrate with a room temperature stable aqueous polysaccharide solution containing, water, a polysaccharide having a concentration in the aqueous solution from about 0.1% to about 20%, a gel-inhibiting agent having a concentration in the aqueous solution from about 18 to about 54%, and an anionic fluorosurfactant having a concentration in the aqueous solution from about 0.001% to about 10% by total weight of the aqueous solution. Followed by evaporating the water from the polysaccharide coating; and exposing the dehydrated polysaccharide coating to a gelling agent form a porous polysaccharide hydrogel coated substrate. The hydrogel coated substrate is exposed to a crosslinking agent to form a porous crosslinked polysaccharide hydrogel coated substrate, which is then functionalized by the attachment of a ligand.Type: ApplicationFiled: August 30, 2011Publication date: December 22, 2011Applicant: Millipore CorporationInventors: Wilson Moya, Neil P. Soice
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Patent number: 8008476Abstract: The present invention provides methods for making porous crosslinked polysaccharide hydrogel coated structures. The methods include impregnating a porous substrate with a room temperature stable aqueous polysaccharide solution containing, water, a polysaccharide having a concentration in the aqueous solution from about 0.1% to about 20%, a gel-inhibiting agent having a concentration in the aqueous solution from about 18 to about 54%, and an anionic fluorosurfactant having a concentration in the aqueous solution from about 0.001% to about 10% by total weight of the aqueous solution. Followed by evaporating the water from the polysaccharide coating; and exposing the dehydrated polysaccharide coating to a gelling agent form a porous polysaccharide hydrogel coated substrate. The hydrogel coated substrate is exposed to a crosslinking agent to form a porous crosslinked polysaccharide hydrogel coated substrate.Type: GrantFiled: March 26, 2010Date of Patent: August 30, 2011Assignee: Millipore CorporationInventors: Wilson Moya, Neil P. Soice
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Publication number: 20110049042Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.Type: ApplicationFiled: November 2, 2010Publication date: March 3, 2011Applicant: Millipore CorporationInventors: Anthony J. DiLeo, Justin McCue, Wilson Moya, Igor Quinones-Garcia, Neil P. Soice, Volkmar Thom, Sarah Yuan
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Patent number: 7824548Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.Type: GrantFiled: June 21, 2007Date of Patent: November 2, 2010Assignee: Millipore CorporationInventors: Anthony J. DiLeo, Justin McCue, Wilson Moya, Igor Quinones-Garcia, Neil P. Soice, Volkmar Thom, Sarah Yuan
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Patent number: 7807823Abstract: A process for forming polysaccharide structures such as beads, gel films and porous coatings on porous substrates by forming a room temperature gel-inhibited solution of a polysaccharide, one or more gel-inhibiting agent(s) and a solvent such as water, heating the mixture until all the components are dissolved, cooling the mixture as a solution to about room temperature, forming a three dimensional structure with the solution and adding the structure to a gelling agent to form a polysaccharide gel. Optionally, the solution can be added to a porous structure such as a non-woven fabric or a porous membrane and the solution is allowed to dry before being subjected to the gelling agent. Porous structures having a polysaccharide coating and being capable of convective flow through the pores of the structure and diffusive flow through the coating can be formed.Type: GrantFiled: February 3, 2005Date of Patent: October 5, 2010Assignee: Millipore CorporationInventors: Wilson Moya, Neil P. Soice, Volkmar Thom
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Publication number: 20100227015Abstract: The present invention relates to a method and apparatus for forming agarose or cored agarose beads. The process involves dissolving/gelation the agarose in a suitable liquid, mixing it with a hydrophobic liquid to form an emulsion and maintaining that emulsion at a temperature equal to or greater than the gelation point of the agarose, passing it through a static mixer to create agarose droplets and solidifying the agarose droplets in a second bath of hydrophobic liquid. The beads can then be washed and used or further processed to crosslink the agarose and/or add various functionalities on to the agarose. Another method for solidifying the agarose droplets is by using a heat exchanger to cool the stream continuously after it exits the static mixer. A similar process is used for the “cored” beads except cores, preferably in bead form, are introduced to the agarose before it enters the first hydrophobic liquid so that the agarose forms a coating on the cores.Type: ApplicationFiled: March 2, 2010Publication date: September 9, 2010Applicant: Millipore CorporationInventors: Kwok-Shun Cheng, Senthilkumar Ramaswamy, Nanying Bian, Brian Gagnon, Joaquin Umana, Neil P. Soice
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Publication number: 20100196589Abstract: Room temperature stable, non-gelling polysaccharide solutions such as agaroses, dextrans and cyclodextrans are made by the present invention. It has been found that by incorporating certain gel-inhibiting additives into an aqueous polysaccharide solution, the gel point is reduced or eliminated and the solution remains liquid at room temperature indefinitely. Additives that have been found to work include salts, such as lithium chloride and zinc chloride and bases, such as sodium hydroxide and lithium hydroxide. Mixtures of said salts and said bases can also be used with the same desired results. The composition of these solutions of the present idea can be further modified to include other additives, such as organic co-solvents or non-solvents, pH modifiers, surfactants or other polymers to customize the properties of the solution to improve the processability for the desired application and to form structures such as films, beads and coated porous substrates.Type: ApplicationFiled: March 26, 2010Publication date: August 5, 2010Applicant: Millipore CorporationInventors: Wilson Moya, Neil P. Soice
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Patent number: 7687619Abstract: Room temperature stable, non-gelling polysaccharide solutions such as agaroses, dextrans and cyclodextrans are made by the present invention. It has been found that by incorporating certain gel-inhibiting additives into an aqueous polysaccharide solution, the gel point is reduced or eliminated and the solution remains liquid at room temperature indefinitely. Additives that have been found to work include salts, such as lithium chloride and zinc chloride and bases, such as sodium hydroxide and lithium hydroxide. Mixtures of said salts and said bases can also be used with the same desired results. The composition of these solutions of the present idea can be further modified to include other additives, such as organic co-solvents or non-solvents, pH modifiers, surfactants or other polymers to customize the properties of the solution to improve the processability for the desired application and to form structures such as films, beads and coated porous substrates.Type: GrantFiled: February 3, 2005Date of Patent: March 30, 2010Assignee: Millipore CorporationInventors: Wilson Moya, Neil P. Soice
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Publication number: 20100065498Abstract: The present invention provides porous media or membranes having a surface coating that includes a cross-linked terpolymer which has a superior combination of properties, including heat stable biomolecule resistant adsorptive properties, resistance to strong alkaline solutions, and low levels of extractable matter. In some preferred embodiments, the porous media is a porous membrane.Type: ApplicationFiled: October 15, 2009Publication date: March 18, 2010Applicant: MILLIPORE CORPORATIONInventors: John Charkoudian, Neil P. Soice
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Patent number: 7678302Abstract: The present invention relates to a method and apparatus for forming agarose or cored agarose beads. The process involves dissolving/gelation the agarose in a suitable liquid, mixing it with a hydrophobic liquid to form an emulsion and maintaining that emulsion at a temperature equal to or greater than the gelation point of the agarose, passing it through a static mixer to create agarose droplets and solidifying the agarose droplets in a second bath of hydrophobic liquid. The beads can then be washed and used or further processed to crosslink the agarose and/or add various functionalities on to the agarose. Another method for solidifying the agarose droplets is by using a heat exchanger to cool the stream continuously after it exits the static mixer. A similar process is used for the “cored” beads except cores, preferably in bead form, are introduced to the agarose before it enters the first hydrophobic liquid so that the agarose forms a coating on the cores.Type: GrantFiled: September 13, 2006Date of Patent: March 16, 2010Assignee: Millipore CorporationInventors: Kwok-Shun Cheng, Senthilkumar Ramaswamy, Nanying Bian, Brian Gagnon, Joaquin Umana, Neil P. Soice
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Patent number: 7648034Abstract: The present invention provides porous media or membranes having a surface coating that includes a cross-linked terpolymer which has a superior combination of properties, including heat stable biomolecule resistant adsorptive properties, resistance to strong alkaline solutions, and low levels of extractable matter. In some preferred embodiments, the porous media is a porous membrane.Type: GrantFiled: April 26, 2002Date of Patent: January 19, 2010Assignee: Millipore CorporationInventors: John Charkoudian, Neil P. Soice
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Patent number: 7479223Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be crosslinked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.Type: GrantFiled: February 3, 2005Date of Patent: January 20, 2009Assignee: Millipore CorporationInventors: Anthony J. DiLeo, Justin McCue, Wilson Moya, Igor Quinones-Garcia, Neil P. Soice, Volkmar Thom, Sarah Yuan
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Patent number: 7479222Abstract: A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtration of desired species including biomolecules such as proteins and DNA fragments.Type: GrantFiled: February 3, 2005Date of Patent: January 20, 2009Assignee: Millipore CorporationInventors: Anthony J. DiLeo, Justin McCue, Wilson Moya, Igor Quinones-Garcia, Neil P. Soice, Volkmar Thom, Sarah Yuan
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Publication number: 20030077435Abstract: The present invention provides porous media or membranes having a surface coating that includes a cross-linked terpolymer which has a superior combination of properties, including heat stable biomolecule resistant adsorptive properties, resistance to strong alkaline solutions, and low levels of extractable matter. In some preferred embodiments, the porous media is a porous membrane.Type: ApplicationFiled: April 26, 2002Publication date: April 24, 2003Inventors: John Charkoudian, Neil P. Soice