Patents by Inventor Neil Talbot
Neil Talbot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240067614Abstract: The invention relates to compounds of formula (I): and related aspects.Type: ApplicationFiled: September 1, 2021Publication date: February 29, 2024Applicant: NRG Therapeutics Ltd.Inventors: Neil MILLER, Richard RUTTER, Jan KULAGOWSKI, Richard MORPHY, Tammy LADDUWAHETTY, John MACLEAN, Mustafa MOROGLU, Eric TALBOT, Michael ROWLEY
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Publication number: 20240009452Abstract: A method of forming a nerve cuff by combining a plurality of electrically conductive members with respective rear surfaces and grit blasted front surfaces with a nerve cuff body, which includes a respective plurality of windows, in such a manner that exposed portions of the grit blasted front surfaces are within the windows.Type: ApplicationFiled: March 20, 2023Publication date: January 11, 2024Applicant: The Alfred E. Mann Foundation for Scientific ResearchInventors: Christopher Reed Jenney, Neil Talbot, Joseph L. Calderon, Sahar Elyahoodayan, William Andrew Brandt
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Publication number: 20230405327Abstract: The present disclosure generally relates to systems and methods for a stimulation system. Various aspects of the present disclosure relate generally to the treatment of epilepsy, depression and/or other conditions in a subject using a nerve stimulator and, more particularly, to an effective and quicker titration method for selection of stimulation parameters of the nerve stimulator using biological markers that indicate potential therapeutic effects. Some aspects of the present disclosure may utilize a pupillometry sensor synchronized with the VNS stimulation system to compare pupil size of a subject with stimulation on and off and for obtaining filtered pupil response measurements after stimulating each electrode while modulating the stimulation parameters. Thus, aspects of the present disclosure allow for quicker titration of programmable stimulation parameters (e.g.Type: ApplicationFiled: March 8, 2023Publication date: December 21, 2023Inventors: Brian Michael SHELTON, Brian MECH, Valma KLEIN, Neil TALBOT, Robert GREENBERG
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Publication number: 20230390570Abstract: A stimulation device includes a first transmitting coil and a drive circuit electrically coupled to the first transmitting coil and configured to drive the first transmitting coil. The first transmitting coil is configured, when the device is in proximity to a person's ear and the first transmitting coil is driven with a time-varying electric current providable by the drive circuit, to generate at least part of a magnetic field providing a time-varying magnetic flux across an auricular branch of a Vagus Nerve (ABVN) sufficient to activate the ABVN.Type: ApplicationFiled: February 16, 2023Publication date: December 7, 2023Inventors: Brian Michael Shelton, Neil Talbot, Brian Dearden
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Publication number: 20230321444Abstract: The disclosure provides systems and methods for automatically titrating an electrical pulse amplitude for a patient-implanted VNS stimulator. One or more external sensors (e.g., EEG, EKG, EMG, auditory sensors, inertial motion sensors, etc.) can be applied to the patient to generate data relevant to an acceptable amplitude of the electrical pulse for a given cathode in a multi-cathode cuff. In one embodiment, the device may include a controller on the implanted VNS stimulator that receives data, e.g., using a wireless connection, from the external sensors and titrates upward the amplitude until an acceptable amplitude is determine that provides efficacy with minimal, if any, side effects.Type: ApplicationFiled: March 30, 2023Publication date: October 12, 2023Inventors: Brian Michael Shelton, Brian Mech, Valma Klein, Neil Talbot, Hitesh Hotlani
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Publication number: 20230248302Abstract: The present disclosure generally relates to devices, systems, and methods for detecting, monitoring, predicting, and/or treating medical conditions (e.g., epileptic seizures) using one or more sensors configured to collect biomarker data from a human subject (e.g., vagal tone and/or physiological or other biomarkers).Type: ApplicationFiled: February 9, 2023Publication date: August 10, 2023Inventors: Brian V. MECH, Neil Talbot, Brian M. Shelton, Joseph L. Calderon, Robert J. Greenberg
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Publication number: 20220313987Abstract: An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.Type: ApplicationFiled: March 1, 2022Publication date: October 6, 2022Applicant: The Alfred E. Mann Foundation for Scientific ResearchInventors: Christopher Reed Jenney, Oren Gotlib, Joseph Calderon, William Andrew Brandt, Neil Talbot
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Publication number: 20220062629Abstract: An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.Type: ApplicationFiled: September 1, 2021Publication date: March 3, 2022Applicant: The Alfred E. Mann Foundation for Scientific ResearchInventors: Brian Ralph Dearden, Brian M. Shelton, Neil Talbot
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Patent number: 11219758Abstract: Electrode arrays for biological implants are disclosed. The present disclosure provides array designs for improving apposition (reducing the space between the array and neural tissue). The present disclosure also provides electrode array designs that can be made approximately spherical to increase the field of view of a visual prosthesis while still maintaining good apposition to neural tissue.Type: GrantFiled: September 16, 2019Date of Patent: January 11, 2022Assignee: Second Sight Medical Products, Inc.Inventors: Robert Greenberg, Neil Talbot, Jerry Ok, Proyag Datta, Andrew Sha, Brianna Thielen, Dustin Tobey, Deborah Sigel
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Patent number: 10667404Abstract: Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced.Type: GrantFiled: October 28, 2007Date of Patent: May 26, 2020Assignees: Second Sight Medical Products, Inc., Doheny Eye InstituteInventors: Robert Greenberg, Neil Talbot, Jordan Neysmith, Dilek Guven, James Little, Brian Mech, Mark Humayun
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Publication number: 20200009373Abstract: Electrode arrays for biological implants are disclosed. The present disclosure provides array designs for improving apposition (reducing the space between the array and neural tissue). The present disclosure also provides electrode array designs that can be made approximately spherical to increase the field of view of a visual prosthesis while still maintaining good apposition to neural tissue.Type: ApplicationFiled: September 16, 2019Publication date: January 9, 2020Applicant: Second Sight Medical Products, Inc.Inventors: Robert Greenberg, Neil Talbot, Jerry Ok, Proyag Datta, Andrew Sha, Brianna Thielen, Dustin Tobey, Deborah Sigel
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Patent number: 10493267Abstract: Electrode arrays for biological implants are disclosed, particularly for stimulating a retina. The present disclosure provides array for improving apposition (reducing the space between the array and the retina. The present disclosure also provides electrode array designs that can be made approximately spherical to increase the field of view of a visual prosthesis while still maintaining good apposition.Type: GrantFiled: December 9, 2016Date of Patent: December 3, 2019Assignee: Second Sight Medical Products, Inc.Inventors: Robert Greenberg, Neil Talbot, Jerry Ok, Proyag Datta, Andrew Sha, Brianna Thielen, Dustin Tobey, Deborah Sigel
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Patent number: 10220202Abstract: A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on the polymer base layer and the metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.Type: GrantFiled: May 2, 2017Date of Patent: March 5, 2019Assignee: Second Sight Medical Products, Inc.Inventors: Jordan Neysmith, Robert Greenberg, James Little, Brian Mech, Neil Talbot, Qingfang Yao, David Zhou
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Patent number: 10159845Abstract: The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package that is suitable for implantation in living tissue, for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.Type: GrantFiled: November 13, 2015Date of Patent: December 25, 2018Assignee: Second Sight Medical Products, Inc.Inventors: Robert J. Greenberg, Alfred E. Mann, Dao Min Zhou, Neil Talbot, Jerry Ok, Gailland R. Nolan
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Patent number: 9861820Abstract: The present invention consists of an implantable device with a hermetic electronics package that houses electronics. The hermetic package is attached to a flexible circuit electrode array having its electrodes arranged in a trapezoidal electrode array field that is suitable to stimulate the visual cortex. The hermetic electronics package is provided with a fixation structure that secures, protects and dissipates heat from the electronics package. The entire implantable device can be entirely implanted within the head.Type: GrantFiled: May 13, 2016Date of Patent: January 9, 2018Assignee: Second Sight Medical Products, Inc.Inventors: Robert J. Greenberg, Neil Talbot, Proyag Datta, Dustin Tobey, Dao Min Zhou, Jessy Dorn
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Patent number: 9849297Abstract: The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package, that is suitable for implantation in living tissue, such as for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a studbump connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.Type: GrantFiled: November 18, 2016Date of Patent: December 26, 2017Assignee: Second Sight Medical Products, Inc.Inventors: Robert J Greenberg, Neil Talbot, Jerry Ok, Jordan Neysmith, David Zhou
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Publication number: 20170232251Abstract: A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on the polymer base layer and the metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.Type: ApplicationFiled: May 2, 2017Publication date: August 17, 2017Applicant: Second Sight Medical Products, Inc.Inventors: Jordan Neysmith, Robert Greenberg, James Little, Brian Mech, Neil Talbot, Qingfang Yao, David Zhou
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Publication number: 20170165476Abstract: Electrode arrays for biological implants are disclosed, particularly for stimulating a retina. The present disclosure provides array for improving apposition (reducing the space between the array and the retina. The present disclosure also provides electrode array designs that can be made approximately spherical to increase the field of view of a visual prosthesis while still maintaining good apposition.Type: ApplicationFiled: December 9, 2016Publication date: June 15, 2017Applicant: Second Sight Medical Products, Inc.Inventors: Robert Greenberg, Neil Talbot, Jerry Ok, Proyag Datta, Andrew Sha, Brianna Thielen, Dustin Tobey, Deborah Sigel
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Patent number: 9669209Abstract: A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.Type: GrantFiled: April 18, 2016Date of Patent: June 6, 2017Assignee: Second Sight Medical Products, Inc.Inventors: Jordan Neysmith, Robert Greenberg, James Little, Brian Mech, Neil Talbot, Qingfang Yao, Dao Min Zhou
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Publication number: 20170095671Abstract: The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package, that is suitable for implantation in living tissue, such as for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a studbump connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.Type: ApplicationFiled: November 18, 2016Publication date: April 6, 2017Inventors: Robert J. Greenberg, Neil Talbot, Jerry Ok, Jordan Neysmith, David Zhou