Patents by Inventor Neil W. Johnson

Neil W. Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20140107131
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Application
    Filed: October 7, 2013
    Publication date: April 17, 2014
    Applicant: GlaxoSmithKline LLC
    Inventors: Jerry Leroy ADAMS, Thomas H. FAITG, Neil W. JOHNSON, Jiri KASPAREC, Hong LIN, Mark MELLINGER, Xin PENG, Ren XIE
  • Benzene Sulfonamide Thiazole and Oxazole Compounds
    Publication number: 20140080851
    Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
    Type: Application
    Filed: November 25, 2013
    Publication date: March 20, 2014
    Applicant: GLAXOSMITHKLINE LLC
    Inventors: GEORGE ADJABENG, JERRY LEROY ADAMS, SCOTT HOWARD DICKERSON, KEITH HORNBERGER, NEIL W. JOHNSON, KEVIN KUNTZ, KIMBERLY PETROV, JEFFREY M. RALPH, TARA RENAE RHEAULT, GREGORY SCHAAF, JOHN STELLWAGEN, XINRONG TIAN, DAVID E. UEHLING, ALEX G. WATERSON, BRIAN WILSON
  • CYCLOPROPYLAMINES AS LSD1 INHIBITORS
    Publication number: 20140018393
    Abstract: This invention relates to the use of cyclopropylamine derivatives for the modulation, notably the inhibition of the activity of Lysine-specific demethylase 1 (LSD1). Suitably, the present invention relates to the use of cyclopropylamines in the treatment of cancer.
    Type: Application
    Filed: March 26, 2012
    Publication date: January 16, 2014
    Inventors: Neil W. Johnson, Jiri Kasparec
  • Benzene Sulfonamide Thiazole And Oxazole Compounds
    Publication number: 20130144055
    Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
    Type: Application
    Filed: January 31, 2013
    Publication date: June 6, 2013
    Applicant: GlaxoSmithKline LLC
    Inventors: George Adjabeng, Jerry Leroy Adams, Scott Howard Dickerson, Keith Hornberger, Neil W. Johnson, Kevin Kuntz, Kimberly Petrov, Jeffrey M. Ralph, Tara Renae Rheault, Gregory Schaaf, John Stellwagen, Xinrong Tian, David E. Uehling, Alex G. Waterson, Brian Wilson
  • Benzene sulfonamide thiazole and oxazole compounds
    Patent number: 8415345
    Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: April 9, 2013
    Assignee: Glaxo SmithKline LLC
    Inventors: George Adjabeng, Jerry Leroy Adams, Scott Howard Dickerson, Keith Hornberger, Neil W. Johnson, Kevin Kuntz, Kimberly Petrov, Jeffrey M. Ralph, Tara Renae Rheault, Gregory Schaaf, John Stellwagen, Xinrong Tian, David E. Uehling, Alex G. Waterson, Brian Wilson
  • PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20110207743
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Application
    Filed: October 27, 2009
    Publication date: August 25, 2011
    Inventors: Jerry Leroy Adams, Thomas H Faitg, Neil W Johnson, Hong Lin
  • Benzene Sulfonamide Thiazole And Oxazole Compounds
    Publication number: 20110172215
    Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
    Type: Application
    Filed: May 4, 2009
    Publication date: July 14, 2011
    Inventors: George Adjabeng, Jeffrey Leroy Adams, Scott Howard Dickerson, Keith Hornberger, Neil W. Johnson, Kevin Kuntz, Kimberly Petrov, Jeffrey M. Ralph, Tara Renae Rheault, Gregory Schaaf, John Stellwagen, Xinrong Tian, David E. Uehling, Alex G. Waterson, Brian Wilson
  • Anthranilamide inhibitors of aurora kinase
    Patent number: 7884098
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1? R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: February 8, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Jeffrey Michael Axten, Deborah L. Bryan, David Harold Drewry, Thomas H Faitg, Timothy Francis Gallagher, Neil W Johnson, Jiri Kasparec, Jeffrey M Ralph, Domingos J. Silva
  • ANILINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20100317663
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, Q, Z, r, and p are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with FAK overexpression, including proliferative diseases.
    Type: Application
    Filed: February 19, 2009
    Publication date: December 16, 2010
    Inventors: Jerry Leroy Adams, Thomas H. Faitg, Neil W. Johnson, Xin Peng
  • PYRIDOSULFONAMIDE DERIVATIVES AS P13 KINASE INHIBITORS
    Publication number: 20100311736
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using pyridosulfonamide derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of pyridosulfonamide derivatives.
    Type: Application
    Filed: October 22, 2008
    Publication date: December 9, 2010
    Inventors: Nicholas D. Adams, Michael Gerard Darcy, Neil W. Johnson, Jiri Kasparec, Steven David Knight, Kenneth Allen Newlander, Xin Peng, Lance H. Ridgers
  • PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK
    Publication number: 20100113475
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
    Type: Application
    Filed: October 27, 2009
    Publication date: May 6, 2010
    Inventors: Jerry Leroy ADAMS, Thomas H. Faitg, Neil W. Johnson, Hong Lin
  • ANTHRANILAMIDE INHIBITORS OF AURORA KINASE
    Publication number: 20100016318
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1? R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Application
    Filed: January 25, 2008
    Publication date: January 21, 2010
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Jeffrey Michael Axten, Deborah L. Bryan, David Harold Drewry, Thomas H. Faitg, Timothy Francis Gallagher, Neil W. Johnson, Jiri Kasparec, Jeffrey M. Ralph, Domingos J. Silva
  • Benzene Sulfonamide Thiazole and Oxazole Compounds
    Publication number: 20090298815
    Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
    Type: Application
    Filed: May 4, 2009
    Publication date: December 3, 2009
    Inventors: Jerry Leroy Adams, Scott Howard Dickerson, Neil W. Johnson, Kevin Kuntz, Kimberly Petrov, Jeffrey M. Ralph, Tara Renae Rheault, Gregory Schaaf, John Stellwagen, Xinrong Tian, David Edward Uehling, Alex Gregory Waterson, Brian Wilson
  • Anthranilamide inhibitors of Aurora kinase
    Patent number: 7625903
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; where R1, R2, R3, R4, r and s are as previously defined. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: December 1, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Neil W. Johnson, Deborah L. Bryan
  • NOVEL CHEMICAL COMPOUNDS
    Publication number: 20090203692
    Abstract: This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.
    Type: Application
    Filed: May 18, 2006
    Publication date: August 13, 2009
    Inventors: Kevin Duffy, Deping Chai, Mirela Colon, Duke M. Fitch, Sarah Rae King, Antony N. Shaw, Rosanna Tedesco, Kenneth Wiggall, Neil W. Johnson, Michael N. Zimmerman
  • Novel Chemical Compounds
    Publication number: 20080214455
    Abstract: This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.
    Type: Application
    Filed: May 3, 2006
    Publication date: September 4, 2008
    Inventors: Kevin Duffy, Deping Chai, Mirela Colon, Duke M. Fitch, Sarah Rae King, Antony N. Shaw, Rosanna Tedesco, Kenneth Wiggall, Michael N. Zimmerman, Neil W. Johnson, Jiri Kasparec
  • ANTHRANILAMIDE INHIBITORS OF AURORA KINASE
    Publication number: 20080182852
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; where R1, R2, R3, R4, r and s are as previously defined. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Application
    Filed: January 25, 2008
    Publication date: July 31, 2008
    Inventors: Neil W. Johnson, Deborah L. Bryan
  • Diamino-pyrimidines and their use as angiogenesis inhibitors
    Patent number: 7338959
    Abstract: Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: March 4, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Stanley Dawes Chamberlain, Mui Cheung, Holly Kathleen Emerson, Neil W. Johnson, Kristen Elizabeth Nailor, Douglas McCord Sammond, Marcus Semones
  • Compounds
    Patent number: 7189745
    Abstract: The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases, in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: March 13, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Neil W. Johnson, Jeffrey H. Murray
  • Fused isoindolones
    Patent number: 5808060
    Abstract: Disclosed are biologically active, non-indole-containing compounds referred to as fused isoindolones, which are represented by the following general formula: ##STR1## The fused indolones can be obtained by complete chemical synthesis. Methods for making and using the fused isoindolones are disclosed.
    Type: Grant
    Filed: December 9, 1996
    Date of Patent: September 15, 1998
    Assignee: Cephalon, Inc.
    Inventors: Robert L. Hudkins, Neil W. Johnson