Patents by Inventor Nello Mainolfi

Nello Mainolfi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRBN ligands and uses thereof
    Patent number: 11932635
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
    Type: Grant
    Filed: November 28, 2022
    Date of Patent: March 19, 2024
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20240059674
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 10, 2023
    Publication date: February 22, 2024
    Inventors: Nello MAINOLFI, Nan Ji, Mathew M. Weiss, Xiaozhang Zheng, Yi Zhang, Paul R. Fleming
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230398223
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: April 24, 2023
    Publication date: December 14, 2023
    Inventors: Nello MAINOLFI, Nan JI, Arthur F. KLUGE, Matthew M. WEISS, Yi ZHANG
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230365562
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: January 31, 2023
    Publication date: November 16, 2023
    Inventors: Nello MAINOLFI, Chris DE SAVI, Matthew M. WEISS, Xiao ZHU, Xiaozhang ZHENG, Bruce C. FOLLOWS
  • IRAK degraders and uses thereof
    Patent number: 11807636
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: February 14, 2022
    Date of Patent: November 7, 2023
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang, Xiaozhang Zheng
  • 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF
    Publication number: 20230348386
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: November 22, 2022
    Publication date: November 2, 2023
    Inventor: Nello MAINOLFI
  • 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF
    Publication number: 20230312536
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: March 1, 2023
    Publication date: October 5, 2023
    Inventor: Nello MAINOLFI
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230303526
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 10, 2023
    Publication date: September 28, 2023
    Inventors: Nello MAINOLFI, Nan JI, Matthew M. WEISS, Xiaozhang ZHENG, Yi ZHANG, Paul R. FLEMING
  • PROTEIN DEGRADERS AND USES THEREOF
    Publication number: 20230295180
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
    Type: Application
    Filed: August 18, 2022
    Publication date: September 21, 2023
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge
  • Stat degraders and uses thereof
    Patent number: 11746120
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: October 10, 2022
    Date of Patent: September 5, 2023
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Bin Yang, Yi Zhang
  • IRAK degraders and uses thereof
    Patent number: 11723980
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: February 10, 2022
    Date of Patent: August 15, 2023
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang
  • CRBN LIGANDS AND USES THEREOF
    Publication number: 20230234950
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
    Type: Application
    Filed: November 28, 2022
    Publication date: July 27, 2023
    Inventors: Nello MAINOLFI, Nan JI, Arthur F. KLUGE
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230219945
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 17, 2020
    Publication date: July 13, 2023
    Inventors: Nello MAINOLFI, Nan JI, Matthew M. WEISS, Xiaozhang ZHENG, Yi ZHANG, Paul R. FLEMING, Xiao ZHU
  • 3-phosphoglycerate dehydrogenase inhibitors and uses thereof
    Patent number: 11634412
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: April 25, 2023
    Assignee: Raze Therapeutics, Inc.
    Inventor: Nello Mainolfi
  • STAT DEGRADERS AND USES THEREOF
    Publication number: 20230120381
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: October 10, 2022
    Publication date: April 20, 2023
    Inventors: Nello MAINOLFI, Nan JI, Bin YANG, Yi ZHANG
  • PROTEIN DEGRADERS AND USES THEREOF
    Publication number: 20230115184
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
    Type: Application
    Filed: June 10, 2022
    Publication date: April 13, 2023
    Inventors: Nello MAINOLFI, Nan Ji, Yi Zhang, Matthew M. Weiss
  • Protein degraders and uses thereof
    Patent number: 11623932
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: April 11, 2023
    Assignee: KYMERA THERAPEUTICS, INC.
    Inventors: Nello Mainolfi, Nan Ji, Yi Zhang, Matthew M. Weiss
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230106066
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: February 10, 2022
    Publication date: April 6, 2023
    Inventors: Nello MAINOLFI, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230101353
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 30, 2021
    Publication date: March 30, 2023
    Inventors: Nello Mainolfi, Nan Ji, Matthew M. Weiss, Xiaozhang Zheng, Yi Zhang, Paul R. Fleming, Xiao Zhu
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230089916
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.
    Type: Application
    Filed: June 29, 2020
    Publication date: March 23, 2023
    Inventors: Nello MAINOLFI, Nan JI, Matthew M. WEISS, Xiaozhang ZHENG, Yi ZHANG, Paul R. FLEMING