Patents by Inventor Nelson Alexander
Nelson Alexander has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11959838Abstract: The disclosure generally relates to the preparation of representative samples from clinical samples, e.g., tumors (whole or in part), lymph nodes, metastases, cysts, polyps, or a combination or portion thereof, using mechanical and/or biochemical dissociation methods to homogenize intact samples or large portions thereof. The resulting homogenate provides the ability to obtain a correct representative sample despite spatial heterogeneity within the sample, increasing detection likelihood of low prevalence subclones, and is suitable for use in various diagnostic assays as well as the production of therapeutics, especially “personalized” anti-tumor vaccines or immune cell based therapies.Type: GrantFiled: April 27, 2018Date of Patent: April 16, 2024Assignee: Ventana Medical Systems, Inc.Inventors: Nelson Alexander, Aoune Barhoumi, Melinda Day, Lisa Gallegos, Katherine Leith, Samantha Rajkovich, Esteban Roberts, Stacey Stanislaw, Eric Walk
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Publication number: 20240077391Abstract: The present disclosure provides a method of separating cellular particles from a tissue sample and then sorting the cellular particles into two or more cellular particle populations.Type: ApplicationFiled: August 11, 2023Publication date: March 7, 2024Inventors: Nelson Alexander, Aoune Barhoumi, Lisa Gallegos, Stacey Stanislaw
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Patent number: 11906523Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: GrantFiled: April 23, 2020Date of Patent: February 20, 2024Assignee: VENTANA MEDICAL SYSTEMS, INC.Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, II, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Patent number: 11768137Abstract: The present disclosure provides a method of separating cellular particles from a tissue sample and then sorting the cellular particles into two or more cellular particle populations.Type: GrantFiled: September 16, 2019Date of Patent: September 26, 2023Assignee: VENTANA MEDICAL SYSTEMS, INC.Inventors: Nelson Alexander, Aoune Barhoumi, Lisa Gallegos, Stacey Stanislaw
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Publication number: 20230174233Abstract: This disclosure describes a moonroof accessory panel. The moonroof accessory panel may be a structure that may be removably attached to a moonroof area of a vehicle. The moonroof accessory panel may be used to hold a drone associated with the vehicle such that the drone may take-off from and land on the moonroof accessory panel. The top of the moonroof accessory panel may also be accessible from the cabin of the vehicle such that a user may place the drone on top of the moonroof accessory panel while inside the cabin. The moonroof accessory panel may also be used for other purposes beyond holding drones as well.Type: ApplicationFiled: December 7, 2021Publication date: June 8, 2023Applicant: Ford Global Technologies, LLCInventor: Nelson Alexander Brock
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Publication number: 20220178934Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: ApplicationFiled: February 23, 2022Publication date: June 9, 2022Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, II, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Publication number: 20200333349Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: ApplicationFiled: April 23, 2020Publication date: October 22, 2020Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Publication number: 20200326345Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: ApplicationFiled: February 10, 2020Publication date: October 15, 2020Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, II, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Publication number: 20200319193Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: ApplicationFiled: April 23, 2020Publication date: October 8, 2020Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Publication number: 20200249238Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: ApplicationFiled: April 23, 2020Publication date: August 6, 2020Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Publication number: 20200049599Abstract: The disclosure generally relates to the preparation of representative samples from clinical samples, e.g., tumors (whole or in part), lymph nodes, metastases, cysts, polyps, or a combination or portion thereof, using mechanical and/or biochemical dissociation methods to homogenize intact samples or large portions thereof. The resulting homogenate provides the ability to obtain a correct representative sample despite spatial heterogeneity within the sample, increasing detection likelihood of low prevalence subclones, and is suitable for use in various diagnostic assays as well as the production of therapeutics, especially “personalized” anti-tumor vaccines or immune cell based therapies.Type: ApplicationFiled: April 27, 2018Publication date: February 13, 2020Inventors: Nelson Alexander, Aoune Barhoumi, Melinda Day, Lisa Gallegos, Katherine Leith, Samantha Rajkovich, Esteban Roberts, Stacey Stanislaw, Eric Walk
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Patent number: 10557851Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: GrantFiled: July 18, 2018Date of Patent: February 11, 2020Assignee: Ventana Medical Systems, Inc.Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, II, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Publication number: 20200011775Abstract: The present disclosure provides a method of separating cellular particles from a tissue sample and then sorting the cellular particles into two or more cellular particle populations.Type: ApplicationFiled: September 16, 2019Publication date: January 9, 2020Inventors: Nelson Alexander, Aoune Barhoumi, Lisa Gallegos, Stacey Stanislaw
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Publication number: 20190018018Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: ApplicationFiled: July 18, 2018Publication date: January 17, 2019Inventors: Nelson ALEXANDER, William Day, Jerome W. Kosmeder, II, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Publication number: 20180328932Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: ApplicationFiled: July 18, 2018Publication date: November 15, 2018Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, II, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Patent number: 10041950Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: GrantFiled: March 22, 2013Date of Patent: August 7, 2018Assignee: VENTANA MEDICAL SYSTEMS, INC.Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, II, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Publication number: 20180170209Abstract: An exemplary battery assembly includes an enclosure defining an interior, and a service panel that covers an opening to the interior. The service panel is held relative to the enclosure by a clip. An exemplary method includes covering an opening in an enclosure with a service panel that is clipped to the enclosure. The opening permits access to a serviceable part housed inside of the enclosure assembly prior to the covering.Type: ApplicationFiled: December 16, 2016Publication date: June 21, 2018Inventors: Patrick Daniel Maguire, Nelson Alexander Brock
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Publication number: 20160362730Abstract: The present disclosure concerns novel methods for analyzing biological samples using photo-cleavable moieties that facilitate target detection and/or biomarker isolation. In some embodiments, the method concerns using a probe comprising a photo-cleavable moiety and a selective irradiation technique for activating/cleaving the photo-cleavable moiety thereby providing facile isolation of the probe or probe components. Also disclosed herein is a system and kit for implementing the methods disclosed herein.Type: ApplicationFiled: August 26, 2016Publication date: December 15, 2016Inventors: Nelson Alexander, Larry Morrison, Sedide Ozturk
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Publication number: 20130260379Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.Type: ApplicationFiled: March 22, 2013Publication date: October 3, 2013Applicant: Ventana Medical Systems, Inc.Inventors: Nelson Alexander, William Day, Jerome W. Kosmeder, II, Mark Lefever, Larry Morrison, Anne M. Pedata, Stacey Stanislaw
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Publication number: 20120070862Abstract: Disclosed herein are uniquely distinct nucleic acid tags and methods for their use and production. The disclosed tags do not hybridize to a genome of interest and thus can be used as labels without generating background signal associated with unintended hybridization. In one example, tag sequences are derived from a genome divergent to the genome of interest. The divergent genome provides a vast library of potential tag sequences. These potential tag sequences can be screened using a bioinformatics-based approach against the genome of interest. These potentially distinct sequences can then be synthesized and tested empirically against the genome of interest to identify those sequences that are uniquely distinct. The tags can then be produced, for example by oligonucleotide synthesis techniques.Type: ApplicationFiled: November 4, 2011Publication date: March 22, 2012Inventors: Nelson Alexander, Stacey Stanislaw