Patents by Inventor Nelson Robert A.
Nelson Robert A. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11959838Abstract: The disclosure generally relates to the preparation of representative samples from clinical samples, e.g., tumors (whole or in part), lymph nodes, metastases, cysts, polyps, or a combination or portion thereof, using mechanical and/or biochemical dissociation methods to homogenize intact samples or large portions thereof. The resulting homogenate provides the ability to obtain a correct representative sample despite spatial heterogeneity within the sample, increasing detection likelihood of low prevalence subclones, and is suitable for use in various diagnostic assays as well as the production of therapeutics, especially “personalized” anti-tumor vaccines or immune cell based therapies.Type: GrantFiled: April 27, 2018Date of Patent: April 16, 2024Assignee: Ventana Medical Systems, Inc.Inventors: Nelson Alexander, Aoune Barhoumi, Melinda Day, Lisa Gallegos, Katherine Leith, Samantha Rajkovich, Esteban Roberts, Stacey Stanislaw, Eric Walk
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Patent number: 11938295Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.Type: GrantFiled: September 15, 2022Date of Patent: March 26, 2024Assignee: Biora Therapeutics, Inc.Inventors: Jeffrey A. Shimizu, Mitchell Lawrence Jones, Mark Sasha Drlik, Iman Niknia, Nathan John Muller, Tuyen Nguyen, Christopher Loren Wahl, Edward Mudge, Nicholas Mark Salt, Nia Eleri Stevens, Stuart Robert Abercrombie, Christopher Ian Bunce, Ryan Elliott Jones, Kevin Howe, Pejman Rahimian, Nelson Quintana
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Publication number: 20150203786Abstract: The invention provides the invention provides compositions and methods for the enzymatic treatment (“bleaching” or “de-colorizing”) of chlorophyll-comprising compositions, e.g., algae preparations, chlorophyll-containing or chlorophyll-contaminated feeds, foods or oils, for example, vegetable oils, including oils processed from oilseeds, such as canola (rapeseed) oil or soybean oil, or oil fruits, such as palm oil. In one aspect, the invention provides methods using a chlorophyllase enzyme for the enzymatic hydrolysis of chlorophyll in an algae, an animal (e.g., a fish) or plant preparation, a food or an oil. In one aspect, the chlorophyllase is immobilized onto a silica. The invention also provides compositions of manufacture and detergents.Type: ApplicationFiled: March 27, 2015Publication date: July 23, 2015Inventors: David LAM, David WEINER, Timothy HITCHMAN, Nelson Robert BARTON, Mark BURK
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Patent number: 7432097Abstract: In one aspect, the invention provides a purified and modified phytase enzyme from Escherichia coli K12 appA phytase. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved protease stability at low pH. Glycosylation of the modified phytase provided a further improved enzyme having improved thermal tolerance and protease stability. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In one aspect, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.Type: GrantFiled: September 1, 2004Date of Patent: October 7, 2008Assignee: Verenium CorporationInventors: Jay M. Short, Keith A. Kretz, Kevin A. Gray, Nelson Robert Barton, James B. Garrett, Eileen O'Donoghue, William Baum, Dan E. Robertson, Paul Zorner
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Publication number: 20080070291Abstract: The invention provides compositions and methods for the enzymatic treatment (“bleaching” or “de-colorizing”) of chlorophyll-comprising compositions, e.g., algae preparations, chlorophyll-containing or chlorophyll-contaminated feeds, foods or oils, for example, vegetable oils, including oils processed from oilseeds, such as canola (rapeseed) oil or soybean oil, or oil fruits, such as palm oil. In one aspect, the invention provides methods using a chlorophyllase enzyme for the enzymatic hydrolysis of chlorophyll in an algae, an animal (e.g., a fish) or plant preparation, a food or an oil. In one aspect, the chlorophyllase is immobilized onto a silica. The invention also provides compositions of manufacture and detergents.Type: ApplicationFiled: June 14, 2005Publication date: March 20, 2008Inventors: David Lam, David Weiner, Timothy Hitchman, Nelson Robert Barton, Mark Burk
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Patent number: 7238824Abstract: Methods, compounds, and kits are provided for derivatizing organometallic halide compounds. The methods include reacting an organometallic halide with a reagent to produce an analyte having desired properties. In a preferred form, the analyte has properties that render it more susceptible to chemical analysis in relation to its respective organometallic halide. The compounds include the analyte product of the derivatization reaction. The kits include a reagent and, preferably, some or all of the tools that may be used to perform the derivatization reaction.Type: GrantFiled: June 7, 2004Date of Patent: July 3, 2007Assignee: Agilent Technologies, Inc.Inventor: Nelson Robert Holcomb
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Patent number: 6855365Abstract: A purified and modified phytase enzyme from Escherichia coli K12 appA phytase is provided. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved protease stability at low pH. Glycosylation of the modified phytase provided a further improved enzyme having improved thermal tolerance and protease stability. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.Type: GrantFiled: May 24, 2001Date of Patent: February 15, 2005Assignee: Diversa CorporationInventors: Jay M. Short, Keith A. Kretz, Kevin A. Gray, Nelson Robert Barton, James B. Garrett, Eileen O'Donoghue, Eric J. Mathur
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Publication number: 20020136754Abstract: A purified and modified phytase enzyme from Escherichia coli K12 appA phytase is provided. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved protease stability at low pH. Glycosylation of the modified phytase provided a further improved enzyme having improved thermal tolerance and protease stability. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.Type: ApplicationFiled: May 24, 2001Publication date: September 26, 2002Inventors: Jay M. Short, Keith A. Kretz, Kevin A. Gray, Nelson Robert Barton, James B. Garrett, Eileen O' Donoghue, Eric J. Mathur
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Patent number: 4503307Abstract: A shielding apparatus is provided for containing frozen bags of fluid and re particularly for containing frozen bags of blood components during microwave thaw. The apparatus includes a metal box for receiving a blood bag, the box having a bottom and sides. A metallic lid is provided, and a hinging device pivotally mounts the lid to the box for enclosing the blood bag therein. The lid and optionally the bottom of the box may be provided with an aperture for allowing microwaves to enter the box. Radiation absorbing strips are mounted along the edges of the apertures for absorbing E field reflections toward the blood bag. The apertures allow microwave energy to be concentrated in the more voluminous part of the blood bag while the edges of bag as well as any tubing are shielded by the metallic box. This apparatus prevents boiling of the blood in the lower volume areas of the bag.Type: GrantFiled: June 20, 1983Date of Patent: March 5, 1985Assignee: The United States of America as represented by the Secretary of the NavyInventors: Nancy L. Campbell, John G. Pinto, John A. Drewe, Patrick D. Hayes, Nelson Robert A.