Patents by Inventor Nerina Dodic

Nerina Dodic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds
    Patent number: 11919856
    Abstract: The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as modulators of alpha I antitrypsin and treating diseases associated with alpha antitrypsin, particularly liver diseases.
    Type: Grant
    Filed: June 23, 2022
    Date of Patent: March 5, 2024
    Assignee: UCL BUSINESS LTD
    Inventors: Kate Smith, Alexis Denis, Nerina Dodic, John Liddle, David Lomas
  • Benzimidamides compounds comprising an oxaborinin ring
    Patent number: 11767333
    Abstract: The invention relates to 4-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-3-yl)benzimidamide derivatives and their use in treating diseases and conditions of the skin (for example, Netherton syndrome, rosacea, atopic dermatitis, psoriasis and itch) caused by abnormally high levels of protease activity (particularly of serine proteases such as kallikreins). In addition, the invention relates to compositions containing the derivatives and processes for their preparation.
    Type: Grant
    Filed: May 6, 2022
    Date of Patent: September 26, 2023
    Assignee: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: John Liddle, Ann Louise Walker, Gemma Victoria White, Alexis Denis, Nerina Dodic, Marie-Hélène Fouchet, Anne Bouillot
  • MACROCYCLIC RIP2-KINASE INHIBITORS
    Publication number: 20230126352
    Abstract: The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of RIP2-kinase, and/or mutants thereof, for use in the diagnosis, prevention and/or treatment of RIP2-kinase associated diseases. Moreover, the present invention provides methods of using said compounds, for instance as a medicine or diagnostic agent.
    Type: Application
    Filed: February 1, 2021
    Publication date: April 27, 2023
    Applicant: Oncodesign SA
    Inventors: Yann LAMOTTE, Nérina DODIC, Aurélien TAP, Alexis DENIS, Jean-Marie BRUSO, Mourad DAOUBI KHAMLICHI, Pascal André Rene PENDERITTER
  • NOVEL COMPOUNDS
    Publication number: 20220340525
    Abstract: The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as modulators of alpha 1 antitrypsin and treating diseases associated with alpha antitrypsin, particularly liver diseases.
    Type: Application
    Filed: June 23, 2022
    Publication date: October 27, 2022
    Inventors: Kate SMITH, Alexis DENIS, Nerina DODIC, John LIDDLE, David LOMAS
  • Novel Benzimidamides Compounds Comprising an Oxaborinin Ring
    Publication number: 20220267357
    Abstract: The invention relates to 4-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-3-yl)benzimidamide derivatives and their use in treating diseases and conditions of the skin (for example, Netherton syndrome, rosacea, atopic dermatitis, psoriasis and itch) caused by abnormally high levels of protease activity (particularly of serine proteases such as kallikreins). In addition, the invention relates to compositions containing the derivatives and processes for their preparation.
    Type: Application
    Filed: May 6, 2022
    Publication date: August 25, 2022
    Inventors: John LIDDLE, Ann Louise WALKER, Gemma Victoria WHITE, Alexis DENIS, Nerina DODIC, Marie-Hélène FOUCHET, Anne BOUILLOT
  • Benzimidamides compounds comprising an oxaborinin ring
    Patent number: 11352372
    Abstract: The invention relates to 4-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-3-yl)benzimidamide derivatives and their use in treating diseases and conditions of the skin (for example, Netherton syndrome, rosacea atopic dermatitis, psoriasis and itch) caused by abnormally high levels of protease activity (particularly of serine proteases such as kallikreins). In addition, the invention relates to compositions containing the derivatives and processes for their preparation.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: June 7, 2022
    Assignee: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: John Liddle, Ann Louise Walker, Gemma Victoria White, Alexis Denis, Nerina Dodic, Marie-Hélène Fouchet, Anne Bouillot
  • NOVEL COMPOUNDS
    Publication number: 20210276952
    Abstract: The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as modulators of alpha I antitrypsin and treating diseases associated with alpha antitrypsin, particularly liver diseases.
    Type: Application
    Filed: June 21, 2019
    Publication date: September 9, 2021
    Inventors: Kate SMITH, Alexis DENIS, Nerina DODIC, John LIDDLE, David LOMAS
  • Soluble guanylate cyclase activators and their use
    Patent number: 10472350
    Abstract: The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic compositions. The pharmaceutical compositions are useful for reducing intraocular pressure in animals of the mammalian species.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: November 12, 2019
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Nerina Dodic, Anne Marie Jeanne Bouillot
  • NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE
    Publication number: 20180194756
    Abstract: The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic compositions. The pharmaceutical compositions are useful for reducing intraocular pressure in animals of the mammalian species.
    Type: Application
    Filed: March 5, 2018
    Publication date: July 12, 2018
    Inventors: Nerina DODIC, Anne Marie Jeanne BOUILLOT
  • Soluble guanylate cyclase activators and their use
    Patent number: 9938260
    Abstract: The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic compositions. The pharmaceutical compositions are useful for reducing intraocular pressure in animals of the mammalian species.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: April 10, 2018
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Nerina Dodic, Anne Marie Jeanne Bouillot
  • NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE
    Publication number: 20170305888
    Abstract: The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic compositions. The pharmaceutical compositions are useful for reducing intraocular pressure in animals of the mammalian species.
    Type: Application
    Filed: September 18, 2015
    Publication date: October 26, 2017
    Inventors: Nerina DODIC, Anne Marie Jeanne BOUILLOT
  • NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE
    Publication number: 20160214956
    Abstract: The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic compositions. The pharmaceutical compositions are useful for reducing intraocular pressure in animals of the mammalian species.
    Type: Application
    Filed: September 5, 2014
    Publication date: July 28, 2016
    Applicant: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Krista B. GOODMAN, Achim Hans-Peter KRAUSS, Anne-Charlotte LE MONNIER DE GOUVILLE, Nerina DODIC
  • Phenyloxyalkanonic acid derivatives as hPPAR activators
    Patent number: 7241793
    Abstract: A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein:
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: July 10, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Nerina Dodic, Bernard André Dumaître, Francoise Jeanne Gellibert, Michael Lawrence Sierra
  • Thiazoles inhibitors of the alk-5 receptor
    Publication number: 20060247233
    Abstract: The invention relates to novel aminothiazole derivatives which are inhibitors of the transforming growth factor, (“TGF”)-? signaling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-? type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway
    Type: Application
    Filed: June 14, 2004
    Publication date: November 2, 2006
    Inventors: Nerina Dodic, Frederic Donche, Jeanne Gellibert
  • Carboline derivatives
    Patent number: 7022856
    Abstract: Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: April 4, 2006
    Assignee: LIlly Icos LLC.
    Inventors: Mark W. Orme, Jason S. Sawyer, Agnes Bombrun, Romain L. Gosmini, Anne Bouillot, Nerina Dodic, Michael Sierra
  • Compounds
    Publication number: 20060004051
    Abstract: The invention relates to novel aminothiazole derivatives which are inhibitors of the transforming growth factor, (“TGF”)-? signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-? type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.
    Type: Application
    Filed: July 29, 2003
    Publication date: January 5, 2006
    Inventors: Nerina Dodic, Francoise Gellibert
  • 2-Phenylpyridin-4-yl derivatives as alk5 inhibitors
    Publication number: 20050245520
    Abstract: This invention relates to novel 2-phenylpyridin-4-yl heterocyclyl derivatives which are inhibitors of the transforming growth factor, (“TGF”)-? signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-? type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.
    Type: Application
    Filed: July 29, 2003
    Publication date: November 3, 2005
    Inventors: Nerina Dodic, Francoise Gellibert
  • Compounds
    Publication number: 20050234029
    Abstract: The invention relates to novel imidazopyridine derivatives which are inhibitors of the transforming growth factor, (“TGF”)-? signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-? type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.
    Type: Application
    Filed: July 29, 2003
    Publication date: October 20, 2005
    Inventors: Nerina Dodic, Francoise Gellibert
  • Phenyloxyalkanonic acid derivatives as hppar activators
    Publication number: 20050222424
    Abstract: A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein:
    Type: Application
    Filed: June 18, 2003
    Publication date: October 6, 2005
    Inventors: Nerina Dodic, Bernard Dumaitre, Francoise Gellibert, Michael Sierra
  • Chemical compounds
    Publication number: 20040122035
    Abstract: Compounds of the general structural formula 1
    Type: Application
    Filed: February 12, 2004
    Publication date: June 24, 2004
    Inventors: Mark W. Orme, Jason S Sawyer, Agnes Bombrun, Romain L Gosmini, Anne Bouillot, Nerina Dodic, Michael Sierra