Patents by Inventor Nicholas A. Sather

Nicholas A. Sather has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cancer treatment methods using nanofiber stabilized growth factors
    Patent number: 11964000
    Abstract: Provided herein are compositions comprising peptide amphiphiles, glycosylated peptide amphiphiles (GPAs), supramolecular nanostructures assembled therefrom, and methods of use thereof. The peptide amphiphiles described herein may extend the half-life of bone morphogenic proteins, promote cell differentiation, suppress proliferation, and increase chemosensitivity of cells. Accordingly, the compositions described herein may be used for cancer treatment methods. In particular, provided herein are bone morphogenic proteins bound to peptide amphiphiles and glycosylated peptide amphiphiles or composites thereof, and methods of use of the same for the treatment of cancer. Also, provided herein are bone morphogenic proteins bound to peptide amphiphiles and glycosylated peptide amphiphiles or composites thereof, and methods of use of the same in a combinatorial approach together with chemotherapeutic medications for the treatment of cancer.
    Type: Grant
    Filed: April 12, 2021
    Date of Patent: April 23, 2024
    Assignee: Northwestern University
    Inventors: Samuel I. Stupp, Mark Trosper McClendon, Guifa Xi, Bo Timmy Bjoern Fyrner, Cara S. Smith, Nicholas A. Sather
  • CANCER TREATMENT METHODS USING NANOFIBER STABILIZED GROWTH FACTORS
    Publication number: 20210315972
    Abstract: Provided herein are compositions comprising peptide amphiphiles, glycosylated peptide amphiphiles (GPAs), supramolecular nanostructures assembled therefrom, and methods of use thereof. The peptide amphiphiles described herein may extend the half-life of bone morphogenic proteins, promote cell differentiation, suppress proliferation, and increase chemosensitivity of cells. Accordingly, the compositions described herein may be used for cancer treatment methods. In particular, provided herein are bone morphogenic proteins bound to peptide amphiphiles and glycosylated peptide amphiphiles or composites thereof, and methods of use of the same for the treatment of cancer. Also, provided herein are bone morphogenic proteins bound to peptide amphiphiles and glycosylated peptide amphiphiles or composites thereof, and methods of use of the same in a combinatorial approach together with chemotherapeutic medications for the treatment of cancer.
    Type: Application
    Filed: April 12, 2021
    Publication date: October 14, 2021
    Inventors: Samuel I. Stupp, Mark Trosper McClendon, Guifa Xi, Bo Timmy Bjoern Fyrner, Cara S. Smith, Nicholas A. Sather