Patents by Inventor Nicholas D. P. Cosford

Nicholas D. P. Cosford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF ULK1/2 AND METHODS OF USING SAME
    Publication number: 20230135635
    Abstract: The present disclosure is directed to compounds, compositions, formulations and methods of use thereof in the treatment and prevention of ULK mediated diseases, including cancer.
    Type: Application
    Filed: February 12, 2021
    Publication date: May 4, 2023
    Inventors: Nicholas D.P. COSFORD, Nicole A. BAKAS, Mitchell VAMOS, Reuben J. SHAW, Allison S. LIMPERT, Sonja N. BRUN
  • MONO AND COMBINATION THERAPIES WITH ULK1/2 INHIBITORS
    Publication number: 20230130766
    Abstract: Provided herein are methods of treating diseases, including cancer, with ULK inhibitors, both as monotherapies and in combination with other therapeutic agents.
    Type: Application
    Filed: February 12, 2021
    Publication date: April 27, 2023
    Inventors: Nicholas D.P. COSFORD, Reuben J. SHAW, Nicole A. BAKAS, Allison S. LIMPERT, Sonja N. BRUN, Mitchell VAMOS
  • MACROCYCLIC ULK1/2 INHIBITORS
    Publication number: 20230099804
    Abstract: The present disclosure is directed to compounds, compositions, formulations and methods of use thereof in the treatment and prevention of ULK mediated diseases, including cancer.
    Type: Application
    Filed: February 12, 2021
    Publication date: March 30, 2023
    Inventors: Nicholas D.P. COSFORD, Nicole A. BAKAS, Reuben J. SHAW, Allison S. LIMPERT, Sonja N. BRUN
  • Quinazolinone analogs and use of quinazolinone analogs for treating or preventing certain viral infections
    Patent number: 10611733
    Abstract: Provided is a method for treating or preventing a viral infection in a subject, wherein the viral infection is from a flavivirus selected from the group consisting of Hepatitis C Virus (genotypes 1-7) and Japanese Encephalitis Virus, as well as novel compounds that are useful in the method.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: April 7, 2020
    Assignees: Sanford-Burnham Medical Research Institute, Southern Research Institute
    Inventors: Marintha L. Heil, Nicholas D. P. Cosford, Robert Ardecky, Jiwen Zou
  • Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof
    Patent number: 10377695
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: August 13, 2019
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Raveendra Panickar Dhanya, Douglas J. Sheffler, Nicholas D. P. Cosford
  • Sulfonamide compounds and uses as TNAP inhibitors
    Patent number: 10370333
    Abstract: Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: August 6, 2019
    Assignee: SANFORD-BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Anthony B. Pinkerton, Russell Dahl, Nicholas D. P. Cosford, Jose Luis Millan
  • SULFONAMIDE COMPOUNDS AND USES AS TNAP INHIBITORS
    Publication number: 20190010126
    Abstract: Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.
    Type: Application
    Filed: February 5, 2018
    Publication date: January 10, 2019
    Inventors: Anthony B. PINKERTON, Russell DAHL, Nicholas D.P. COSFORD, Jose Luis MILLAN
  • Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof
    Patent number: 10099993
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: October 16, 2018
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Raveendra Panickar Dhanya, Douglas J. Sheffler, Nicholas D. P. Cosford, Russell Dahl
  • Small molecule fatty acid synthase inhibitors
    Patent number: 10071976
    Abstract: Provided herein are small molecule Fatty Acid Synthase Inhibitors, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: September 11, 2018
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Nicholas D. P. Cosford, Jeffrey Smith
  • Metabotropic Glutamate Receptor Positive Allosteric Modulators (PAMS) and Uses Thereof
    Publication number: 20180194710
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Application
    Filed: November 21, 2017
    Publication date: July 12, 2018
    Inventors: Raveendra Panickar Dhanya, Douglas J. Sheffler, Nicholas D. P. Cosford
  • Sulfonamide compounds and uses as TNAP inhibitors
    Patent number: 9884826
    Abstract: Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: February 6, 2018
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Anthony B. Pinkerton, Russell Dahl, Nicholas D. P. Cosford, Jose Luis Millan
  • QUINAZOLINONE ANALOGS AND USE OF QUINAZOLINONE ANALOGS FOR TREATING OR PREVENTING CERTAIN VIRAL INFECTIONS
    Publication number: 20170144978
    Abstract: Provided is a method for treating or preventing a viral infection in a subject, wherein the viral infection is from a flavivirus selected from the group consisting of Hepatitis C Virus (genotypes 1-7) and Japanese Encephalitis Virus, as well as novel compounds that are useful in the method.
    Type: Application
    Filed: February 6, 2017
    Publication date: May 25, 2017
    Inventors: Marintha L. Heil, Nicholas D.P. Cosford, Robert Ardecky, Jiwen Zou
  • Quinazolinone analogs and use of quinazolinone analogs for treating or preventing certain viral infections
    Patent number: 9598402
    Abstract: Provided is a process for treating or preventing a viral infection in a subject, wherein the viral infection is from a flavivirus selected from the group consisting of Hepatitis C Virus (genotypes 1-7) and Japanese Encephalitis Virus.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: March 21, 2017
    Assignees: Southern Research Institute, Sanford-Burnham Medical Research Institute
    Inventors: Marintha L. Heil, Nicholas D. P. Cosford, Robert Ardecky, Jiwen Zou
  • SMALL MOLECULE FATTY ACID SYNTHASE INHIBITORS
    Publication number: 20170066731
    Abstract: Provided herein are small molecule Fatty Acid Synthase Inhibitors, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Application
    Filed: March 5, 2015
    Publication date: March 9, 2017
    Inventors: Nicholas D.P. COSFORD, Jeffrey SMITH, Robert J. ARDECKY, Jiwen ZOU, Margrith MATTMANN, Peter TERIETE, Lester LAMBERT
  • Metabotropic Glutamate Receptor Positive Allosteric Modulators (PAMS) and Uses Thereof
    Publication number: 20170036987
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Application
    Filed: April 6, 2015
    Publication date: February 9, 2017
    Inventors: Raveendra Panickar DHANYA, Douglas J. SHEFFLER, Nicholas D. P. COSFORD
  • SULFONAMIDE COMPOUNDS AND USES AS TNAP INHIBITORS
    Publication number: 20160355479
    Abstract: Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.
    Type: Application
    Filed: August 19, 2016
    Publication date: December 8, 2016
    Inventors: Anthony B. PINKERTON, Russell DAHL, Nicholas D.P. COSFORD, Jose Luis MILLAN
  • Sulfonamide compounds and uses as TNAP inhibitors
    Patent number: 9458147
    Abstract: Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: October 4, 2016
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Anthony B. Pinkerton, Russell Dahl, Nicholas D. P. Cosford, Jose Luis Millan
  • HIV replication inhibitors
    Patent number: 9120787
    Abstract: Compounds of Formula (I) wherein B is selected from the group consisting of substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; Y is a linker moiety selected from the group consisting of a direct bond. R, R1, R2, and R3 are each individually selected from the group consisting substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or heterocycle.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: September 1, 2015
    Assignees: Southern Research Institute, Sanford-Burnham Medical Research Institute
    Inventors: Marintha L. Heil, Nicholas D. P. Cosford, Nicholas Pagano, Peter Teriete
  • SULFONAMIDE COMPOUNDS AND USES AS TNAP INHIBITORS
    Publication number: 20150011551
    Abstract: Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.
    Type: Application
    Filed: February 21, 2013
    Publication date: January 8, 2015
    Applicant: Sanford- Burnham Medical Reseach Institute
    Inventors: Anthony B. Pinkerton, Russell Dahl, Nicholas D.P. Cosford, Jose Luis Millan
  • QUINAZOLINONE ANALOGS AND USE OF QUINAZOLINONE ANALOGS FOR TREATING OR PREVENTING CERTAIN VIRAL INFECTIONS
    Publication number: 20140256753
    Abstract: Provided is a process for treating or preventing a viral infection in a subject, wherein the viral infection is from a flavivirus selected from the group consisting of Hepatitis C Virus (genotypes 1-7) and Japanese Encephalitis Virus.
    Type: Application
    Filed: August 10, 2012
    Publication date: September 11, 2014
    Applicants: Sanford-Burnham Medical Research Institute, Southern Research Institute
    Inventors: Marintha L. Heil, Nicholas D.P. Cosford, Robert Ardecky, Jiwen Zou