Abstract: Apparatus and method for collecting, storing, transporting, and disposing of biohazardous medical waste material with minimum handling and reduced risk of cross-contamination. A liquid-tight plastic bag (96), disposable fluid collection drape (98), and other disposable items (100) used in a medical procedure are received at the point of use in a vertically expandable paperboard carton (11). During a medical procedure, the drape (98) is used to funnel liquid wastes into the waste receptacle (106) consisting of the opened carton (11) lined with the enclosed bag (96). At the conclusion of the procedure, the drape (98) and other waste materials are also disposed of in the receptacle (106). The bag (96) is sealed closed, left in the carton (11), and the carton (11) is the selectively closed and sealed to the appropriate size to accommodate the volume of wastes in the bag (96). The entire waste receptacle (106) remains sealed until disposed of.