Abstract: The present disclosure relates to methods of treating neurological diseases, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound or pharmaceutical composition according to any embodiment described herein. The present disclosure relates to the methods of treating Parkinson's disease and Dementia with Lew Bodies, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound or pharmaceutical composition according to any embodiment described herein.

Abstract: The present disclosure relates to methods of treating dry age-related macular degeneration (dry AMD), comprising administering to a subject in need thereof, a therapeutically effective amount of a compound or pharmaceutical composition according to any embodiment described herein.

Abstract: The present disclosure relates to methods of decreasing amyloid ? monomers and methods of treating cognitive decline in a subject, wherein the treatment results in an increase in amyloid ? oligomers and a reduction in cognitive decline. The present disclosure relates to treating cognitive decline, wherein target engagement can be measured in the clinic after treating.

Abstract: Compounds having a structure according to Formula (I): are effective in a method of increasing erythropoietin and vascularization of tissue in a subject in need thereof.

Abstract: A business management method integrates a complex, long cycle business into a common, concise format and set of order fulfillment metrics that provide clear status as well as predictive indicators of issues across all functional areas to all levels of management throughout an organization. The uniformity of the approach across all business functions allows for a standard comparison of the fulfillment risks and status across the entire business. The business management method utilizes statistical analysis, variation based metrics, mean based metrics, line rate analysis indicators and key quality indicators to facilitate proactive actions at the senior management level before issues become systemic and/or impact a company's ability to timely deliver products to its customers.