Abstract: In the present specification we describe a new class of compounds, designed to modulate the ability of blood vessels to synthesize NO from L-arginine. In particular we have identified novel compounds which enhance the entry of L-arginine into cells. These compounds improve endothelial function, and thereby have the potential to retard the progression of vascular disease in conditions such as hypertension, heart failure and diabetes. This new class of drugs may also have other potentially, relevant pharmacological actions, including anti-hypertensive and anti-anginal actions.

Abstract: The present invention provides polymers incorporating peptides. The polymers comprise polymarised units of (1) CH2═CR4—CO—X—R1 and (2) CH2═CR3—CO—R2 and optionally one or more other monomers, in which R1 is a peptide. Each R1 may be the same, or is preferably different. In another embodiment the present invention provides polymers formed from CH2═CR4—CO—X—R1 and optionally one or more other monomers, in which X is a spacer having a length equivalent to 1 to 30 single C—C bonds and R1 is a peptide, each R1 being the same or different. The invention further relates to methods producing the polymers and methods of inducing an immune response using the polmers.