Abstract: Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

Abstract: A method of projected capacitance touch sensing on a display screen, the method comprising: updating said display screen by applying a drive waveform to each pixel of the display screen over a plurality of frame periods, wherein a said drive waveform for a pixel defines a transition of the pixel from a current pixel state to an updated pixel state over said plurality of frame periods, and wherein said updating comprises selecting each row of said display screen in turn for a row driving period and driving columns of the display screen with a time slice of drive waveforms for pixels of the row to perform a frame update of said display screen, and repeating said frame update to drive pixels of said display with a plurality of successive time slices of said drive waveforms to drive said pixels with said drive waveforms; sensing a signal from a projected capacitance touch sensing electrode of said display screen during a sensing interval, and using said sensing to provide a touch sensing response; identifying whe

Abstract: In a marine power distribution and propulsion system with a medium voltage distribution busbar (MVAC1) and a low voltage distribution busbar (LVAC1) then a rectifier (SC) is controlled, optionally to provide active filtering and static compensation benefits. A common power supply system incorporating ac generators (G1-G4) supplies power to the medium and low voltage distribution busbars. The rectifier (SC) is connected to the medium voltage distribution busbar (MVAC1). A controller (Co) uses feedback signals indicative of electrical quantities of the distribution voltages carried by both the medium voltage and low voltage distribution busbars (MVAC1, LVAC1) to control the rectifier (SC) to regulate electrical quantities at the ac terminals of the rectifier (SC) in order to achieve desired electrical quantities of the distribution voltage carried by the low voltage distribution busbar (LVAC1).

Abstract: Described herein are compounds that are inhibitors of autotaxin. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such inhibitors, alone and in combination with other compounds, for treating autotaxin-dependent or autotaxin-mediated conditions or diseases.

Abstract: A coupling includes a first portion configured for connection to a first shaft and having a first portion flange and a second portion configured for connection to a second shaft and having a second portion flange. The coupling also includes an isolating member disposed between the first portion flange and the second portion flange and that is formed of ceramic and electrically isolates the first portion from the second portion. The coupling also includes one or more connecting members passing through the first portion flange, the second portion flange, and the isolating member and holding the first portion flange and the second portion flange in a fixed relationship to one another.

Abstract: Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

Abstract: A load coupling device for a power train including: a rotatable shaft; a first flange on a first end of the shaft, wherein the first flange is adapted to couple to a first rotating shaft of at a torque producing turbine or a torque driven electrical generator; a second flange on an opposite end of the shaft, wherein the shaft is adapted to couple to a second rotating shaft of the other of the turbine and the generator, and an annular ring extending radially outward from the first flange, wherein the mass of the annular ring is selected to shift a torsional natural frequency of the power train away from an operational condition of the power train. Trim masses may be added to make fine adjustments to the torsional natural frequency of the power train.

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.

Abstract: Described herein are heteroaryl compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the heteroaryl compounds described. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

Abstract: Described herein are heteroaryl compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the heteroaryl compounds described. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

Abstract: Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions, diseases, or disorders.

Abstract: Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

Abstract: A service that is capable of tracking conversations related to documents, surfaces these documents appropriately to users and enables user-friendly notification of new communications associated with the discussed documents while respecting existing user experience, security, and privacy models of the various document and communication modalities. Conversations about particular content are made available within the context of that content through user interface elements that not only provide access to various communication modes, but also present discussion context in summary or detailed versions.

Abstract: A load coupling for transmitting a torque load between a first shaft and a second shaft is disclosed. The load coupling may generally include a first shaft segment configured to be fixedly attached to the first shaft and a second shaft segment configured to be fixedly attached to the second shaft. The second shaft segment may be frictionally fit within the first shaft segment such that a frictional interface is defined between the first and second shaft segments. Additionally, the frictional interface may be configured such that the first and second shaft segments rotationally disengage when the torque load exceeds a torque threshold and rotationally reengage when the torque load is reduced to or below the torque threshold.

Abstract: The present invention provides processes useful for preparing 5-lipoxygenase activating protein (FLAP) inhibitors and their intermediates. In particular, processes for preparing 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, the anhydrous Form C polymorph of sodium 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionate, and intermediates useful in said processes are provided.

Abstract: Described herein are ophthalmic pharmaceutical compositions, wherein the ophthalmic pharmaceutical compositions are in a form suitable for administration to an eye of a mammal. Ophthalmic pharmaceutical compositions disclosed herein include at least one DP2 receptor antagonist compound and are used to treat or prevent ophthalmic diseases or conditions.

Abstract: Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.

Abstract: An online system enables a customer to complete a purchase based only upon a product offer identifier, e.g., in a promotional campaign or in offers delivered by coupons. Each customer is associated with a customer device, which accesses the online system via a communications network. A database contains customer records, merchant records and product offer records with one or more merchant offers. A product offer identifier is sent from a customer device, and the online system retrieves corresponding merchant offers. A description of the product offer, along with details of the merchant offers is sent back to the customer device. A user of the device selects a merchant offer, and the selection is sent back to the online system. The system is configured to complete a transaction whereby hinds are transferred from a customer account to a selected merchant account, and the merchant is notified of the transaction.

Abstract: A solar concentrator comprises a curved linear Fresnel lens (16) which has a plurality of prismatic features (10, 12, 14). The prismatic features are arranged into at least two segments, in each segment the prismatic features have a common apex angle, the common apex angle differing between adjacent segments. A method of manufacturing a mold (2) for producing a Fresnel lens optical film (16) is disclosed. The method comprises rotating a mold blank, and forming a plurality of different prismatic features (10, 12, 14) on the mold blank by repeatedly advancing a cutting tool (4) onto and then withdrawing the tool away from the surface of the mold blank.