Abstract: Provided herein are cyclic polypeptide compounds that can, e.g., bind specifically to human proprotein convertase subtilisin/kexin type 9 (PCSK9) and optionally also inhibit interaction between human PCSK9 and human low density lipoprotein receptor (LDLR), and pharmaceutical compositions comprising one or more of these compounds. Also provided are methods of reducing LDL cholesterol level in a subject in need thereof that include administering to the subject one or more of the cyclic polypeptide compounds or a pharmaceutical composition provided herein.

Abstract: The present invention is directed to a functionalized elastomer comprising the reaction product of a living anionic elastomeric polymer and a polymerization terminator of formula I wherein R1 is C1 to C4 linear or branched alkanediyl; Z is R2, —OR3, or —R4—X; R2, R3 are independently C1 to C18 linear or branched alkyl; R4 is C1 to C18 alkanediyl; X is halogen or a group of structure II, III, IV, V or VI wherein R5, R6, R7, R8, and R9 are independently H or C1 to C8 alkyl; R10 is C2 to C8 alkanediyl; R11 and R12 are independently H, aryl or C1 to C8 alkyl; Q is N or a group of structure VII wherein R13 is C1 to C8 alkyl.

Abstract: The present invention is directed to a functionalized elastomer comprising the reaction product of a living anionic elastomeric polymer and a polymerization terminator of formula I wherein R1 is C1 to C4 linear or branched alkanediyl; Z is R2, —OR3, or —R4—X; R2, R3 are independently C1 to C18 linear or branched alkyl; R4 is C1 to C18 alkanediyl; X is halogen or a group of structure II, III, IV, V or VI wherein R5, R6, R7, R8, and R9 are independently H or C1 to C8 alkyl; R10 is C2 to C8 alkanediyl; R11 and R12 are independently H, aryl or C1 to C8 alkyl; Q is N or a group of structure VII wherein R13 is C1 to C8 alkyl.

Abstract: The present invention is directed to a pneumatic tire comprising a ground contacting tread, the tread comprising a rubber composition comprising a solution polymerized styrene-butadiene rubber having a bound styrene content of at least 36 percent by weight and a vinyl 1,2 content of less than 25 percent by weight; optionally, at least one additional diene based rubber; silica; a sulfur donor; a sulfenamide accelerator; at least one secondary accelerator selected from the group consisting of guanidines, dithiocarbamates and thiurams; and an ?,?-bis(N,N?-dihydrocarbylthiocarbamamoyldithio)alkane; wherein the zinc content of the rubber composition is less than 0.5 parts by weight, per 100 parts by weight of elastomer (phr) as Zn metal.

Abstract: The present invention is directed to a pneumatic tire comprising a ground contacting tread, the tread comprising a rubber composition comprising at least one additional diene based rubber; silica; a sulfur donor; a sulfenamide accelerator; and a dithiophosphate of the formula wherein Q is divalent Zn or S, and R3 may be identical or different, and R3 is hydrogen or a monovalent hydrocarbon group of 1 to 18 carbon atoms; wherein the zinc content of the rubber composition is less than 0.5 parts by weight, per 100 parts by weight of elastomer (phr) as Zn meta.

Abstract: The present invention is directed to a pneumatic tire comprising a ground contacting tread, the tread comprising a rubber composition comprising a solution polymerized styrene-butadiene rubber having a bound styrene content of at least 36 percent by weight and a vinyl 1,2 content of less than 25 percent by weight; optionally, at least one additional diene based rubber; silica; a sulfur donor; a sulfenamide accelerator; at least one secondary accelerator selected from the group consisting of guanidines, dithiocarbamates and thiurams; and an ?,?-bis(N,N?-dihydrocarbylthiocarbamamoyldithio)alkane; wherein the zinc content of the rubber composition is less than 0.5 parts by weight, per 100 parts by weight of elastomer (phr) as Zn metal.

Abstract: The present invention is directed to a method of conducting static electricity in a pneumatic tire, comprising the steps of mixing a rubber compound comprising at least one diene based rubber, from 60 to 150 phr of precipitated silica, less than 40 phr of carbon black, and from 1 to 10 phr of carbon nanotubes having a length of at least 5 microns; forming a tire tread from the rubber compound; and including the tire tread in the tire; wherein the volume resistivity of the tire tread is less than 1×109 ohm-cm as measured by ASTM D257-98.

Abstract: The present invention is directed to a pneumatic tire comprising a ground contacting tread, the tread comprising a rubber composition comprising from about 60 to about 90 phr of a functionalized solution polymerized styrene-butadiene rubber having a bound styrene content of at least 36 percent by weight, a vinyl 1,2 content of less than 25 percent by weight, and functionalized with an alkoxysilane group and a thiol group; from about 40 to about 10 phr of a high-cis polybutadiene; and from about 50 to about 150 phr of silica.

Abstract: The present invention is directed to a pneumatic tire comprising a ground contacting tread, the tread comprising a rubber composition comprising a solution polymerized styrene-butadiene rubber having a bound styrene content of at least 36 percent by weight and a vinyl 1,2 content of less than 25 percent by weight; optionally, at least one additional diene based rubber; silica; a sulfur donor; a sulfenamide accelerator; at least one secondary accelerator selected from the group consisting of guanidines, dithiocarbamates and thiurams; and an ?,?-bis(N,N?-dihydrocarbylthiocarbamamoyldithio)alkane; wherein the zinc content of the rubber composition is less than 0.5 parts by weight, per 100 parts by weight of elastomer (phr) as Zn metal.

Abstract: The present invention is directed to a pneumatic tire comprising a ground contacting tread, the tread comprising a rubber composition comprising from 30 to 70 parts by weight, per 100 parts by weight of s first elastomer (phr) having a glass transition temperature Tg ranging from about ?40° C. to about ?10° C. and a solubility parameter ranging from about 4.1 MPa1/2 to about 4.5 MPa1/2; from 70 to 30 phr of a second elastomer having a Tg ranging from about ?105° C. to about ?30° C. and a solubility parameter ranging from about 3.7 MPa1/2 to about 4.1 MPa1/2; from 1 to 40 phr of a first plasticizer having a solubility parameter ranging from 3.4 MPa1/2 to 3.8 MPa1/2; from 1 to 20 phr of a second plasticizer having a solubility parameter ranging from 4.3 MPa1/2 to 4.7 MPa1/2; and from 30 to 150 phr of silica.