Patents by Inventor Nicola Mary Aston

Nicola Mary Aston has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nicotinamide derivates useful as P38 inhibitors
    Patent number: 8575204
    Abstract: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: November 5, 2013
    Assignee: GlaxoSmithKline LLC
    Inventors: Nicola Mary Aston, Paul Bamborough, Ann Louise Walker
  • Nicotinamide derivatives useful as P38 inhibitors
    Patent number: 8252818
    Abstract: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: August 28, 2012
    Assignee: GlaxoSmithKline LLC
    Inventors: Nicola Mary Aston, Paul Bamborough, Ann Louise Walker
  • NICOTINAMIDE DERIVATES USEFUL AS P38 INHIBITORS
    Publication number: 20100215661
    Abstract: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
    Type: Application
    Filed: February 26, 2010
    Publication date: August 26, 2010
    Inventors: Nicola Mary ASTON, Paul Bamborough, Ann Louise Walker
  • NICOTINAMIDE DERIVATES USEFUL AS P38 INHIBITORS
    Publication number: 20100215652
    Abstract: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
    Type: Application
    Filed: February 26, 2010
    Publication date: August 26, 2010
    Inventors: Nicola Mary ASTON, Paul Bamborough, Ann Louise Walker
  • Nicotinamide derivatives useful as p38 inhibitors
    Patent number: 7709506
    Abstract: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
    Type: Grant
    Filed: August 7, 2006
    Date of Patent: May 4, 2010
    Assignee: GlaxoSmithkline LLC
    Inventors: Nicola Mary Aston, Paul Bamborough, Ann Louise Walker
  • PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS
    Publication number: 20090325952
    Abstract: The invention provides a compound of formula (I) or a salt thereof: wherein Ar has the sub-formula (x): as defined herein, and the use of the compounds as inhibitors of PDE4.
    Type: Application
    Filed: July 31, 2007
    Publication date: December 31, 2009
    Inventors: David George Allen, Nicola Mary Aston, Rodger Phillip Barnett, Reshma Manesh Chudasama, Caroline Jane Day, Christopher David Edlin, Leanda Jane Kindon, Naimisha Trivedi
  • PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS
    Publication number: 20090318494
    Abstract: The invention provides a compound of formula (I) or a salt thereof: wherein Ar has the sub-formula (w), (y), (z1) or (z2): wherein the several groups are defined herein below, and the use of these compounds as inhibitors of phosphodiesterase type IV (PDE4).
    Type: Application
    Filed: August 1, 2007
    Publication date: December 24, 2009
    Inventors: David George Allen, Nicola Mary Aston, Naimisha Trivedi, Christopher David Edlin
  • Biphenyl-carboxamide derivatives and their use as p38 kinase inhibitors
    Patent number: 7626055
    Abstract: Compounds of formula (I) or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: December 1, 2009
    Assignee: SmithKline Beecham Corporation
    Inventor: Nicola Mary Aston
  • Biphenyl carboxylic amide p38 kinase inhibitors
    Patent number: 7572790
    Abstract: Compound of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: August 11, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicola Mary Aston, Paul Bamborough, Katherine Louise Jones, Vipulkumar Kantibhai Patel, Stephen Swanson, Ann Louise Walker
  • Nicotinamide derivatives useful as p38 inhibitors
    Patent number: 7514456
    Abstract: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
    Type: Grant
    Filed: August 7, 2006
    Date of Patent: April 7, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicola Mary Aston, Paul Bamborough, Ann Louise Walker
  • Cinnoline Compounds as Inhibitors of Phosphodiesterase Type IV (Pde4)
    Publication number: 20080280911
    Abstract: There are provided according to the invention novel compounds of formula (I)
    Type: Application
    Filed: October 18, 2006
    Publication date: November 13, 2008
    Applicant: Glaxo Group Limited
    Inventors: Nicola Mary Aston, John Edward Robinson, Naimisha Trivedi
  • 5-Acylamino-1,1?-biphenyl-4-carboxamide derivatives and their use as P38 kinase inhibitors
    Patent number: 7432289
    Abstract: Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: October 7, 2008
    Assignee: Glaxo Group Limited
    Inventors: Richard Martyn Angell, Nicola Mary Aston, Paul Bamborough, Mark James Bamford, George Stuart Cockerill, Stephen Sean Flack, Dramane Ibrahim Lainé, Suzanne Joy Merrick, Kathryn Jane Smith, Ann Louise Walker
  • 5?-carbamoyl-1,1?-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors
    Patent number: 7396843
    Abstract: Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: July 8, 2008
    Assignee: Glaxo Group Limited
    Inventors: Richard Martyn Angell, Nicola Mary Aston, Paul Bamborough, Mark James Bamford, George Stuart Cockerill, Suzanne Joy Merrick, Ann Louise Walker
  • Biphenylcarboxylic amide derivatives as p38 kinase inhibitors
    Patent number: 7309800
    Abstract: Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: December 18, 2007
    Assignee: Glaxo Group Limited
    Inventors: Richard Martyn Angell, Nicola Mary Aston, Paul Bamborough, Mark James Bamford, George Stuart Cockerill, Stephen Sean Flack, Dramane Ibrahim Lainé, Ann Louise Walker
  • Biphenylcarboxylic amide derivatives as p38 kinase inhibitors
    Patent number: 7271289
    Abstract: Compounds of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: September 18, 2007
    Assignee: SmithKline Beecham Corporation
    Inventor: Nicola Mary Aston
  • 5?-Carbamoyl-1,1-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors
    Patent number: 7208629
    Abstract: Compounds of formula (I): wherein when m is 0 to 4 R1 is selected from C1–6alkyl, C3–7cycloalkyl, C2–6alkenyl, —SO2NR4R5, —CONR4R5 and —COOR4; and when m is 2 to 4 R1 is additionally selected from C1–6alkoxy, hydroxy, NR4R5, —NR4SO2R5, —NR4SOR5, —NR4COR5, and —NR4CONR4R5; R2 is selected from hydrogen, C1–6alkyl and —(CH2)n-C3–7cycloalkyl; R3 is the group —CO—NH—(CH2)p-R6; U is selected from methyl and halogen; W is selected from methyl and chlorine; V and Y are each selected independently from hydrogen, methyl and halogen; m is selected from 0, 1, 2, 3 and 4 wherein each carbon atom of the resulting carbon chain may be optionally substituted with one or two groups selected independently from C1–6alkyl; n is selected from 0, 1, 2 and 3; p and r are independently selected from 0, 1 and 2; s is selected from 0, 1 and 2; or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: April 24, 2007
    Assignee: Glaxo Group Limited
    Inventors: Richard Martyn Angell, Nicola Mary Aston, Paul Bamborough, George Stuart Cockerill, Suzanne Joy Merrick, Kathryn Jane Smith, Ann Louise Walker
  • Biphenyl-derivatives as p38-kinase inhibitors
    Patent number: 7183297
    Abstract: Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: February 27, 2007
    Assignee: Glaxo Group Limited
    Inventors: Richard Martyn Angell, Nicola Mary Aston, Paul Bamborough, Mark James Bamford, George Stuart Cockerill, Stephen Sean Flack, Dramane Ibrahim Lainé, Ann Louise Walker
  • Biphenylcarboxylic amide derivatives as p38-kinase inhibitors
    Patent number: 7151118
    Abstract: Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: December 19, 2006
    Assignee: Glaxo Group Limited
    Inventors: Richard Martyn Angell, Nicola Mary Aston, Paul Bamborough, Mark James Bamford, George Stuart Cockerill, Stephen Sean Flack, Dramane Ibrahim Lainé, Ann Louise Walker
  • Nicotinamide derivatives useful as p38 inhibitors.
    Patent number: 7125898
    Abstract: Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: October 24, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicola Mary Aston, Paul Bamborough, Ann Louise Walker
  • 5'-Carbamoyl-1,1-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors
    Publication number: 20040267012
    Abstract: Compounds of formula (I): wherein when m is 0 to 4 R1 is selected from C1-6alkyl, C3-7cycloalkyl, C2-6alkenyl, —SO2NR4R5, —CONR4R5 and —COOR4; and when m is 2 to 4 R1 is additionally selected from C1-6alkoxy, hydroxy, NR4R5, —NR4SO2R5, —NR4SOR5, —NR4COR5, and —NR4CONR4R5; R2 is selected from hydrogen, C1-6alkyl and —(CH2)n-C3-7cycloalkyl; R3 is the group —CO—NH—(CH2)p-R6; U is selected from methyl and halogen; W is selected from methyl and chlorine; V and Y are each selected independently from hydrogen, methyl and halogen; m is selected from 0, 1, 2, 3 and 4 wherein each carbon atom of the resulting carbon chain may be optionally substituted with one or two groups selected independently from C1-6alkyl; n is selected from 0, 1, 2 and 3; p and r are independently selected from 0, 1 and 2; s is selected from 0, 1 and 2; or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors
    Type: Application
    Filed: April 15, 2004
    Publication date: December 30, 2004
    Inventors: Richard Martyn Angell, Nicola Mary Aston, Paul Bamborough, George Stuart Cockerill, Suzanne Joy Merrick, Kathryn Jane Smith, Ann Louise Walker