Abstract: The present invention relates to novel methods for increasing recombination so that the resulting plant or plant material has an increased rate of recombination. In particular, the present invention provides methods for increase of recombination in agricultural plants. Increased recombination is achieved by a controlled temperature treatment by aligning meiosis progression in a specific treatment window to macroscopically or microscopically detectable characteristics. Furthermore, the methods described herein are also useful to shift meiotic recombination to regions in the genome which usually show a reduced amount of recombination. The resulting plants can for example be used to introduce new genetic variations into breeding pools and breeding populations, as the methods can be performed without a significant loss in fertility usually going along with uncontrolled heat/cold treatments.

Abstract: The present invention relates to an engineered polymerase with an expanded substrate range characterised in that the polymerase is capable of incorporating an enhanced occurrence of detection agent-labelled nucleotide analogue into nucleic acid synthesised by that engineered polymerase as compared with the wild type polymerase from which it is derived.

Abstract: The present invention relates to an engineered polymerase with an expanded substrate range characterized in that the polymerase is capable of incorporating an enhanced occurrence of detection agent-labeled nucleotide analogue into nucleic acid synthesized by that engineered polymerase as compared with the wild type polymerase from which it is derived.

Abstract: The invention relates to amino acid residues within an immunoglobulin light chain amino acid sequence (VL) which stabilize the monomeric state of the immunoglobulin single variable domain. In particular, but not exclusively, the invention describes a number of mutations that stabilize the monomeric state of DPK9 framework V? domain antibodies.

Abstract: The present invention relates to an engineered polymerase with an expanded substrate range characterized in that the polymerase is capable of incorporating an enhanced occurrence of detection agent-labeled nucleotide analogue into nucleic acid synthesized by that engineered polymerase as compared with the wild type polymerase from which it is derived.

Abstract: The invention discloses methods of controlling one or more genes in plants. The genes may be exogenous genes and produce a desired phenotypic trait in the plants produced. The genes are operatively linked to a heterologous upstream activating sequence (UAS) recognition site, which is activatable by a transactivating protein. The genes linked to the UAS sequence, and nucleic acid encoding for the transactivating protein may originally be in separate transgenic plants, one of which fertilizes the other to produce reproductive material, such as seed, which may be grown into plants expressing the desired phenotype. The desired phenotype may be herbicide resistance or the production of a polyhydroxyalkanoate, such as polyhydroxybutyrate.

Abstract: The invention discloses methods of controlling one or more genes in plants. The genes may be exogenous genes and produce a desired phenotypic trait in the plants produced. The genes are operatively linked to a heterologous upstream activating sequence (UAS) recognition site, which is activatable by a transactivating protein, such as GAL4. The genes linked to the UAS sequence, and nucleic acid encoding for the transactivating protein may originally be in separate transgenic plants, one of which fertilises the other to produce reproductive material, such as seed, which may be grown into plants expressing the desired phenotype. The desired phenotype may be herbicide resistance or the production of a polyhydroxyalkanoate, such as polyhydroxybutyrate.