Abstract: A method of programming a device comprising acquiring configuration data, loading the configuration data onto a programmable device, processing at least a portion of the configuration data through a one way function to form processed configuration data, and configuring at least one configurable module of the programmable device using the processed configuration data from the processing step.

Abstract: The present disclosure includes methods, devises and systems for preparing and installing one or more application keys owned by application owners in a remote device. The present disclosure further proposes methods, devices and systems for secure installation of subsequent application keys on a device utilising corresponding key derivation functions to associate an application with a respective policy and identifier using significantly Imv bandwidth for transfer of keys for execution of the respective application on the device.

Abstract: The present invention relates to antibody arms which bind agonistically to human CD28. The present invention relates to bispecific antibodies which bind to human carcinoembryonic antigen (CEA) and human CD28 using the agonist anti-CD28 arms described herein. The present invention relates to bispecific antibodies which bind to human mesothelin (MSLN) and human CD28 using the agonist anti-CD28 arms described herein.

Abstract: The invention relates to monoclonal and/or monovalent antibodies that bind CD47. The invention relates to monoclonal and/or monovalent antibodies that bind CD19. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD47. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD19.

Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-CD19 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind CD19, as well as methods of making and using these anti-CD19 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: The present disclosure provides compositions of bispecific antibodies useful in selective cytokine activation on immune cells. The present disclosure also provides compositions of bispecific antibodies useful for treatment of cancers that express tumor associated antigens.

Abstract: Provided herein are methods and compositions using a target moiety linked to an active agent, in particular an antimicrobial agent. Such methods and compositions are useful in treating, e.g., microbial infections, such as antibiotic-resistant bacterial infections. Provided herein are methods and compositions using a target moiety linked to an active agent, in particular an antimicrobial agent. Such methods and compositions are useful in treating, e.g., microbial infections, such as antibiotic-resistant bacterial infections.

Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-CD19 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind CD19, as well as methods of making and using these anti-CD19 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: Composite-structure rotor for axial flow electrical machines comprising at least one stator and a rotor rigidly connected to a shaft to be rotated, in the shape of a disc and comprising a plurality of permanent magnets supported by a support made of a composite material rigidly connected to the shaft to be driven and constituted by a reinforced fibre matrix, The rotor comprises distributed attachment means for the radial elements and segments, which connect the elements in pairs, forming recesses, and which comprise at least one strap resulting from the winding of continuous unidirectional fibres passing between th Composite-structure rotor for axial flow electrical machines comprising at least one stator and a rotor rigidly connected to a shaft to be rotated, in the shape of a disc and comprising a plurality of permanent magnets supported by a support made of a composite material rigidly connected to the shaft to be driven and constituted by a reinforced fibre matrix.

Abstract: The present invention relates in particular to a pairing method between a multimedia unit and one operator having an operator identifier, the multimedia unit having a multimedia unit identifier and receiving conditional access data from said operator, the method being characterized in that: receiving by the multimedia unit a multimedia unit key formed by applying a first cryptographically function to a personalization key and to the multimedia unit identifier; receiving by the operator an operator key formed by applying a second cryptographically function to said personalization key and to the operator identifier; said multimedia unit further having a function of the multimedia unit and said operator further having a function of the operator, these functions being such that the result of the application of the function of the operator to said operator key and to said multimedia unit identifier is equal to the result of the application of the function of the multimedia unit to said multimedia unit key a

Abstract: The present disclosure includes methods, devises and systems for preparing and installing one or more application keys owned by application owners in a remote device. The present disclosure further proposes methods, devices and systems for secure installation of subsequent application keys on a device utilising corresponding key derivation functions to associate an application with a respective policy and identifier using significantly Imv bandwidth for transfer of keys for execution of the respective application on the device.

Abstract: A method of programming a device comprising acquiring configuration data, loading the configuration data onto a programmable device, processing at least a portion of the configuration data through a one way function to form processed configuration data, and configuring at least one configurable module of the programmable device using the processed configuration data from the processing step.

Abstract: The present disclosure includes methods, devises and systems for preparing and installing one or more application keys owned by application owners in a remote device. The present disclosure further proposes methods, devices and systems for secure installation of subsequent application keys on a device utilising corresponding key derivation functions to associate an application with a respective policy and identifier using significantly low bandwidth for transfer of keys for execution of the respective application on the device.

Abstract: Disclosed are antibodies that specifically bind Toll-like Receptor 4 (TLR-4), and to methods of using the anti-TLR4 antibodies as therapeutics and diagnostic agents.

Abstract: This disclosure provides novel bispecific antibodies that specifically bind to CD47 and Programmed Death-Ligand 1 (PD-L1). The disclosure further relates to methods of making the bispecific antibodies and nucleic acids encoding the antibodies. The disclosure further relates to therapeutic methods for use of the bispecific antibodies in the treatment of a condition associated with malignant cells expressing CD47 and/or PD-L1 (e.g. cancer).

Abstract: The invention relates to the generation of multispecific antibody mixtures include a subset of antibodies isolated from a mixture of two or more monospecific antibodies and one or more bispecific antibodies, wherein all antibodies in the subset have the same common heavy chain. The invention also relates to methods of isolating, purifying, or otherwise producing such a subset of antibodies by using at least one affinity chromatography step. The invention also relates to methods of using such a subset of antibodies in a variety of therapeutic indications.

Abstract: A method of programming a device comprising acquiring configuration data, loading the configuration data onto a programmable device, processing at least a portion of the configuration data through a one way function to form processed configuration data, and configuring at least one configurable module of the programmable device using the processed configuration data from the processing step.

Abstract: A method of monitoring execution in an execution environment of an operation, for example a cryptographic operation, comprising a sequence of instructions, is disclosed. Instructions sent in the sequence from a main processor to one or more auxiliary processors, for example cryptographic processors, to execute the operation are monitored and the sequence of instructions is verified using verification information. The method comprises enabling output from the execution environment of a result of the operation in response to a successful verification of the sequence, or generating a verification failure signal in response to a failed verification of the sequence.

Abstract: The invention also relates to novel bispecific antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD47 and the second is specific for mesothelin (MSLN).

Abstract: The invention provides heterodimer bispecific antigen-binding molecules that include a first polypeptide that does not include an IgG CH1 domain and a second polypeptide where there is at least one mutation in the IgG CH3 domain that abolishes the ability of the second polypeptide to bind CH3-specific affinity media such that the first and second polypeptides have different affinities with respect to CH1 and CH3 specific affinity reagents that allows rapid isolation by differential binding. The invention also provides bispecific antibodies that have CH1 and CH3 regions with different affinities with respect to affinity reagents that allows rapid isolation by differential binding. The invention also concerns bispecific antibodies which are heterodimers of two IgG heavy chains that differ by at least two amino acids that allow for rapid isolation based on a differential affinity of one mutated heavy chain and a second mutated heavy chain toward two different affinity reagents.