Patents by Inventor Nicole Guiso-Maclouf

Nicole Guiso-Maclouf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptides containing polymorphisms of the repeated regions of pertactin in , and , their use in diagnostics, and in immunogenic compositions
    Patent number: 7314910
    Abstract: Pertactin (PRN) is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, which induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed the pertactin of B. parapertussis is invariant, whereas the pertactin of B. pertussis varies mostly in region I and B. bronchiseptica varies in both the repeated regions I and II. Compositions containing pertactins and pertactin fragments containing variant sequences in these regions are useful as immunogenic compositions.
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: January 1, 2008
    Assignee: Institut Pasteur
    Inventors: Caroline Boursaux-Eude, Nicole Guiso-Maclouf
  • Use of adenylate cyclase or bacteria producing it as vaccines against
    Patent number: 7211263
    Abstract: The invention relates to a method of immunizing a mammal against infection by a first Bordetella species. The method comprises administering to the mammal a preparation comprising a portion of the amino acid sequence of mature adenylate cyclase of a second Bordetella species. The invention also relates to vaccine preparations comprising a portion of the amino acid sequence of mature adenylate cyclase from Bordetella species.
    Type: Grant
    Filed: January 2, 2003
    Date of Patent: May 1, 2007
    Assignee: Institut Pasteur
    Inventor: Nicole Guiso-Maclouf
  • POLYPEPTIDES CONTAINING POLYMORPHISMS OF THE REPEATED REGIONS OF PERTACTIN IN BORDETELLA PERTUSSIS, BORDETELLA PARAPERTUSSIS, AND BORDETELLA BRONCHISEPTICA, THEIR USE IN DIAGNOSTICS, AND IN IMMUNOGENIC COMPOSITIONS
    Patent number: 7070779
    Abstract: Pertactin (PRN) is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, which induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed the pertactin of B. parapertussis is invariant, whereas the pertactin of B. pertussis varies mostly in region I and B. bronchiseptica varies in both the repeated regions I and II. Compositions containing pertactins and pertactin fragments containing variant sequences in these regions are useful as immunogenic compositions.
    Type: Grant
    Filed: May 16, 2001
    Date of Patent: July 4, 2006
    Assignee: Institut Pasteur
    Inventors: Caroline Boursaux-Eude, Nicole Guiso-Maclouf
  • Polypeptides containing polymorphisms of the repeated regions of pertactin in Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, their use in diagnostics, and in immunogenic compositions
    Publication number: 20060008474
    Abstract: Pertactin (PRN) is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, which induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed the pertactin of B. parapertussis is invariant, whereas the pertactin of B. pertussis varies mostly in region I and B. bronchiseptica varies in both the repeated regions I and II. Compositions containing pertactins and pertactin fragments containing variant sequences in these regions are useful as immunogenic compositions.
    Type: Application
    Filed: March 25, 2005
    Publication date: January 12, 2006
    Inventors: Caroline Boursaux-Eude, Nicole Guiso-Maclouf
  • POLYPEPTIDES CONTAINING POLYMORPHISMS OF THE REPEATED REGIONS OF PERTACTIN IN BORDETELLA PERTUSSIS, BORDETELLA PARAPERTUSSIS, AND BORDETELLA BRONCHISEPTICA, THEIR USE IN DIAGNOSTICS, AND IN IMMUNOGENIC COMPOSITIONS
    Patent number: 6964767
    Abstract: Pertactin (PRN) is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, which induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed the pertactin of B. parapertussis) is invariant, whereas the pertactin of B. pertussis varies mostly in region I and B. bronchiseptica varies in both the repeated regions I and II. Compositions containing pertactins and pertactin fragments containing variant sequences in these regions are useful as immunogenic compositions.
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: November 15, 2005
    Assignee: Institut Pasteur
    Inventors: Nicole Guiso-Maclouf, Caroline Boursaux-Eude
  • Polypeptides containing polymorphisms of the repeated regions of pertactin in Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, their use in diagnostics, and in immunogenic compositions
    Publication number: 20040166116
    Abstract: Pertactin (PRN) is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, which induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed the pertactin of B. parapertussis) is invariant, whereas the pertactin of B. pertussis varies mostly in region I and B. bronchiseptica varies in both the repeated regions I and II. Compositions containing pertactins and pertactin fragments containing variant sequences in these regions are useful as immunogenic compositions.
    Type: Application
    Filed: November 25, 2002
    Publication date: August 26, 2004
    Inventors: Nicole Guiso-Maclouf, Caroline Boursaux-Eude
  • Use of adenylate cyclase or bacteria producing it as vaccines against bordetella
    Publication number: 20030224003
    Abstract: The invention relates to a method of immunizing a mammal against infection by a first Bordetella species. The method comprises administering to the mammal a preparation comprising a portion of the amino acid sequence of mature adenylate cyclase of a second Bordetella species. The invention also relates to vaccine preparations comprising a portion of the amino acid sequence of mature adenylate cyclase from Bordetella species.
    Type: Application
    Filed: January 2, 2003
    Publication date: December 4, 2003
    Applicant: Institut Pasteur
    Inventor: Nicole Guiso-Maclouf
  • Polypeptides containing polymorphisms of the repeated regions of pertactin in Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, their use in diagnostics, and in immunogenic compositions
    Publication number: 20030180307
    Abstract: Pertactin (PRN) is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, which induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed the pertactin of B. parapertussis) is invariant, whereas the pertactin of B. pertussis varies mostly in region I and B. bronchiseptica varies in both the repeated regions I and II. Compositions containing pertactins and pertactin fragments containing variant sequences in these regions are useful as immunogenic compositions.
    Type: Application
    Filed: November 25, 2002
    Publication date: September 25, 2003
    Inventors: Nicole Guiso-Maclouf, Caroline Boursaux-Eude
  • Polypeptides containing polymorphisms of the repeated regions of pertactin in bordetella pertussis, bordetella parapertussis, and bordetella bronchiseptica, their use in diagnostics, and in immunogenic compositions
    Publication number: 20020192237
    Abstract: Pertactin (PRN) is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica, which induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed the pertactin of B. parapertussis is invariant, whereas the pertactin of B. pertussis varies mostly in region I and B. bronchiseptica varies in both the repeated regions I and II. Compositions containing pertactins and pertactin fragments containing variant sequences in these regions are useful as immunogenic compositions.
    Type: Application
    Filed: September 10, 2001
    Publication date: December 19, 2002
    Inventors: Caroline Boursaux-Eude, Nicole Guiso-Maclouf
  • Use of adenylate cyclase or bacteria producing it as vaccines against bordetella
    Publication number: 20020172691
    Abstract: The invention provides for the utilisation of a bacterial vaccining preparation elaborated from a given bacterium of the genus Bordetella or an adenyl cyclase in order to prepare an antigen for the protection of human beings or animals against infections and the toxic effects caused by a bacterium of the genus Bordetella but different from that of the vaccining preparation.
    Type: Application
    Filed: January 30, 2001
    Publication date: November 21, 2002
    Inventor: Nicole Guiso-Maclouf
  • Use of adenylate cyclase or bacteria producing it as vaccines against bordetella
    Patent number: 6214356
    Abstract: The invention relates to a method for immunizing a mammal against infection by a first Bordetella species. The method comprises administering to the mammal a preparation comprising a portion of the amino acid sequence of mature adenylate cyclase of a second Bordetella species. The invention also relates to vaccine preparations comprising a portion of the amino acid sequence of mature adenylate cyclase from Bordetella species.
    Type: Grant
    Filed: August 7, 1992
    Date of Patent: April 10, 2001
    Assignee: Institut Pasteur
    Inventor: Nicole Guiso-Maclouf