Patents by Inventor Nicole M. CHUMBLER

Nicole M. CHUMBLER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating or preventing infection
    Patent number: 9926345
    Abstract: Clostridium difficile is a leading cause of antibiotic-associated infection in hospitals worldwide. There is a need for a vaccine to Clostridium difficile that can target toxic proteins, or that can elicit adequate immunity to prevent infection or reduce the severity of infection. Modified Clostridium difficile toxin A and B (TcdA and TcdB) proteins are described herein, which comprise mutations that reduce toxin A and B toxicity compared to the native toxin. The proteins described are highly similar to the native toxin of Clostridium difficile, but toxicity is reduced.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: March 27, 2018
    Assignees: THE HOSPITAL FOR SICK CHILDREN, VANDERBILT UNIVERSITY
    Inventors: Roman Melnyk, Zhifen Zhang, John Tam, Dana Borden Lacy, Stacey A. Seeback, Nicole M. Chumbler
  • COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING CLOSTRIDIUM INFECTION
    Publication number: 20170008937
    Abstract: Clostridium difficile is a leading cause of antibiotic-associated infection in hospitals worldwide. There is a need for a vaccine to Clostridium difficile that can target toxic proteins, or that can elicit adequate immunity to prevent infection or reduce the severity of infection. Modified Clostridium difficile toxin A and B (TcdA and TcdB) proteins are described herein, which comprise mutations that reduce toxin A and B toxicity compared to the native toxin. The proteins described are highly similar to the native toxin of Clostridium difficile, but toxicity is reduced.
    Type: Application
    Filed: February 17, 2015
    Publication date: January 12, 2017
    Inventors: Roman MELNYK, Zhifen ZHANG, John TAM, Dana Borden LACY, Stacey A. SEEBACK, Nicole M. CHUMBLER