Abstract: The present disclosure relates to seating apparatus. In particular, the present application relates to an aircraft seat (1). The aircraft seat (1) includes a seat chassis (4) and a seat assembly (5). The seat assembly (5) has a seat pan (6) and a seat back (7). The seat pan (6) is mounted to the seat chassis (4) by a first pivoting connection (30) defining a seat pan pivot axis (Y1) about which the seat pan (6) pivots. The location of the seat pan pivot axis (Y1) is fixed relative to the seat chassis (4). At least one seat pan link (53-1) is provided for controlling pivoting of the seat pan (6) about said seat pan pivot axis (Y1). The at least one seat pan link (53-1) is coupled to the seat pan (6) in front of the seat pan pivot axis (Y1). The present disclosure also relates to an aircraft (2) including one or more of the aircraft seat (1).

Abstract: An aircraft seat including: a seat chassis; a seat assembly including a seat pan and a seat back; the seat pan being mounted to the seat chassis by a first pivoting connection defining a seat pan pivot axis about which the seat pan pivots, the first pivoting connection being configured such that the seat pan can pivot about the seat pan pivot axis without undergoing a related translational movement; the second pivoting connection defining a seat back pivot axis about which the seat back pivots; at least one seat pan link for controlling pivoting of the seat pan about said seat pan pivot axis; wherein the at least one seat pan link is coupled to the seat pan in front of the seat pan pivot axis; and at least one recline link connected to the seat back and the at least one seat pan link.

Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Additionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable of producing antibody cytokine engrafted proteins, as well as methods of combining antibody cytokine engrafted proteins with other therapeutics in treating immune related disorder.

Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Additionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable of producing antibody cytokine engrafted proteins, as well as methods of combining antibody cytokine engrafted proteins with other therapeutics in treating immune related disorder.

Abstract: The present disclosure relates to seating apparatus. In particular, the present application relates to an aircraft seat (1). The aircraft seat (1) includes a seat chassis (4) and a seat assembly (5). The seat assembly (5) has a seat pan (6) and a seat back (7). The seat pan (6) is mounted to the seat chassis (4) by a first pivoting connection (30) defining a seat pan pivot axis (Y1) about which the seat pan (6) pivots. The location of the seat pan pivot axis (Y1) is fixed relative to the seat chassis (4). At least one seat pan link (53-1) is provided for controlling pivoting of the seat pan (6) about said seat pan pivot axis (Y1). The at least one seat pan link (53-1) is coupled to the seat pan (6) in front of the seat pan pivot axis (Y1). The present disclosure also relates to an aircraft (2) including one or more of the aircraft seat (1).

Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Additionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable of producing antibody cytokine engrafted proteins, as well as methods of combining antibody cytokine engrafted proteins with other therapeutics in treating immune related disorder.

Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Additionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable of producing antibody cytokine engrafted proteins, as well as methods of combining antibody cytokine engrafted proteins with other therapeutics in treating immune related disorder.