Patents by Inventor Nicole Willard

Nicole Willard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazoles as inhibitors of tumor necrosis factor
    Patent number: 7541368
    Abstract: The present invention provides compounds of Formula (I) and ester prodrugs, pharmaceutically acceptable salts or solvates of such compounds; or ester prodrugs of such salts or solvates; pharmaceutical compositions comprising such compounds, their preparation, and their pharmaceutical use in the treatment of disease states capable of being modulated by the inhibition of p38 kinase and/or tumor necrosis factor (TNF).
    Type: Grant
    Filed: November 1, 2005
    Date of Patent: June 2, 2009
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: David Roger Borcherding, Alexandre Gross, Patrick W. Shum, Nicole Willard, Brian S. Freed
  • Pyrazoles as inhibitors of tumor necrosis factor
    Publication number: 20060063796
    Abstract: The present invention provides compounds of Formula (I) and ester prodrugs, pharmaceutically acceptable salts or solvates of such compounds; or ester prodrugs of such salts or solvates; pharmaceutical compositions comprising such compounds, their preparation, and their pharmaceutical use in the treatment of disease states capable of being modulated by the inhibition of p38 kinase and/or tumor necrosis factor (TNF).
    Type: Application
    Filed: November 1, 2005
    Publication date: March 23, 2006
    Applicant: Aventis Pharmaceuticals Inc.
    Inventors: David Borcherding, Alexandre Gross, Patrick Shum, Nicole Willard, Brian Freed
  • Method of making free acids from polysaccharide salts
    Publication number: 20050090662
    Abstract: A free acid form of a polysaccharide is produced from its alkali-metal salt. In one example, free-form hyaluronic acid is produced by preparing a solution of an alkali-metal salt of hyaluronic acid, dispersing into the solution a strong acid, enclosing the dispersion within a semi-permeable membrane, dialyzing the dispersion in water, and harvesting the product from within the membrane. The strong acid can be hydrochloric acid, sulfuric acid, nitric acid, orthophosphoric acid, or oxalic acid, for example. The semi-permeable membrane is non-ionic, and has a molecular weight cut-off large enough to pass the strong acid, and preferably much larger. The invention provides a simple and economical way to produce a product which is not commercially available.
    Type: Application
    Filed: November 23, 2004
    Publication date: April 28, 2005
    Inventors: Ellington Beavers, Djoerd Hoekstra, Yee Su, Nicole Willard
  • Method of making free acids from polysaccharide salts
    Patent number: 5789571
    Abstract: A free acid form of a polysaccharide is produced from its alkali-metal salt. In one example, free-form hyaluronic acid is produced by preparing a solution of an alkali-metal salt of hyaluronic acid, dispersing into the solution a strong acid, enclosing the dispersion within a semi-permeable membrane, dialyzing the dispersion in water, and harvesting the product from within the membrane. The strong acid can be hydrochloric acid, sulfuric acid, nitric acid, orthophosphoric acid, or oxalic acid, for example. The semi-permeable membrane has a molecular weight cut-off large enough to pass the strong acid, and preferably much larger. The invention provides a simple and economical way to produce a product which is not commercially available.
    Type: Grant
    Filed: January 15, 1997
    Date of Patent: August 4, 1998
    Assignee: Biocoat Incorporated
    Inventors: Ellington M. Beavers, Djoerd Hoekstra, Yee San Su, Nicole Willard