Abstract: Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and an organoboron derivative. Conversion of the product to another glyoxamide intermediate allows the iterative use of this chemistry for the synthesis of peptides and peptidomimetics.

Abstract: The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides new derivatives of trihydroxy polyunsaturated eicosanoids that can be prepared according to these methods. The invention also provides trihydroxy polyunsaturated eicosanoids and their use in pharmaceutical compositions.

Abstract: Functionalized amine derivatives are prepared by reacting an amine, a carbonyl derivative, and an organoboron compound under mild conditions. Organoboronic acids react with amines and alpha-hydroxy aldehydes to give anti-alpha-amino alcohols with very high diastereoselectivities (>99% de). When optically pure alpha-hydroxy aldehydes are used in this process, no racemization occurs and the products are obtained with very high enantioselectivities (>99% ee). The reaction also works with unprotected glyceraldehyde to give the corresponding amino diol derivatives, while unprotected carbohydrates give the corresponding amino polyols. The chiral amino alcohol products of this process or their derivatives, react further with metals or non-metals to give adducts that are effective catalysts for a variety of asymmetric reactions. Overall, the present invention relies on the facile synthesis of the chiral amino alcohol ligands for the rapid construction of combinatorial libraries of chiral catalysts.

Abstract: Amines and amino acids are prepared by reacting an amine, a carbonyl derivative, and an organoboron compound under mild conditions.

Abstract: Organic light emitting devices are disclosed which are comprised of a heterostructure for producing electoluminescence wherein the heterostructure is comprised of an emissive layer containing a dopant compound selected from the class of azlactone-related compounds having the chemical structure as represented by formula I: ##STR1## where R is hydrogen or a donor or acceptor group relative to hydrogen; R'=alkyl or substituted or unsubstituted aryl;R.sub.1 and R.sub.2 are hydrogen or are joined to form a fused aryl ring;X is O; NR.sub.5, where R.sub.5 is hydrogen or substituted or unsubstituted alkyl; alkyl or substituted or unsubstituted aryl;Z.sub.1 and Z.sub.2 are, independently of one another, a carbon or nitrogen atom; andY is M, a metal atom, whenever Z.sub.1 and Z.sub.2 are both nitrogen atoms;Y is O; NR.sub.6, where R.sub.6 is hydrogen or substituted or unsubstituted alkyl; or S; whenever either Z.sub.1 or Z.sub.2 is a carbon atom; orY is absent.

Abstract: A method for conversion of a starting compound containing a carbon-oxygen double bond to a corresponding product containing a carbon-carbon bond, in particular for conversion of a carbonyl compound to the corresponding olefinic derivative, in which the carbonyl substrate is reacted with an appropriate titanocene derivative. The method is particularly suitable for the olefination of aldehydes, ketones, esters, lactones, amides and lactams. The olefination procedure using these titanocene derivatives proceeds rapidly and in high yield, and is of a more general applicability than heretofore known methods.

Abstract: A series of alkanoarachidonic acids have been prepared as modulators of the arachidonic acid cascade to increase the production of biologically desirable compounds and minimize the production of biologically undesirable compounds. Examples of desirable compounds in this respect comprise postaglandins and thromboxanes whereas undesirable compounds comprise the mono- and polyhydroxyarachidonic acids and leukotrienes. The alkanoarachidonic acids and their intermediates are of the general formula: ##STR1## and at least one of X, Y, and Z is lower alkano and is hydrogen when not lower alkano; the esters and salts of the acids are also prepared. The acids, esters and salts may be used as anti-anaphylaxis or anti-thrombosis agents.

Abstract: A compound of the formula ##STR1## wherein n is an integer from 2 to 4;m is an integer from 3 to 5;R is OM, OR.sub.1 or NR.sub.2 R.sub.3 where M is a pharmaceutically acceptable cation;R.sub.1, R.sub.2 and R.sub.3 are the same or different and selected from the group consisting of hydrogen, C.sub.1 -C.sub.2 branched, unbranched or cyclic alkyl aryl and aralkyl; or R.sub.2 and R.sub.3 taken together from a group of the formula ##STR2## can be used as an inhibitor of the lipoxygenase pathway of the arachidonic acid cascade in animals.

Abstract: A compound of the formula ##STR1## wherein n is an integer from 2 to 4; m is an integer from 3 to 5; R is OM, OR.sub.1 or NR.sub.2 R.sub.3 where M is a pharmaceutically acceptable cation;R.sub.1, R.sub.2 and R.sub.3 are the same or different and selected from the group consisting of hydrogen, C.sub.1 -C.sub.12 branched, unbranched or cyclic alkyl, aryl and aralkyl; or R.sub.2 and R.sub.3 taken together form a group of the formula ##STR2## can be used as an inhibitor of the lipoxygenase pathway of the arachidonic acid cascade in animals.