Patents by Inventor Niels P. H. Moller

Niels P. H. Moller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PTP-S31: A novel protein tyrosine phosphatase
    Patent number: 5585233
    Abstract: A novel protein tyrosine phosphatase designated PTP-S31 and its subfamily are identified, as are nucleic acid molecule coding therefor. Included in this family are PTP-S31 proteins or glycoproteins having one, two, or three identified amino acid changes in previously defined consensus sequences in the catalytic phosphatase domains of known protein tyrosine phosphatases. The PTP-S31 proteins or glycoproteins may be produced by recombinant means. Antibodies to PTP-S31 proteins or glycoproteins and nucleic acid constructs coding therefor, and methods for screening molecules which can bind to PTP-S31 proteins or glycoproteins and inhibit or stimulate their enzymatic activity, are provided.
    Type: Grant
    Filed: March 23, 1993
    Date of Patent: December 17, 1996
    Assignee: Max-Planck Gesellschaft zur Forderung der Wissenschaften E.V.
    Inventors: Niels P. H. Moller, Karin B. Moller, Axel Ullrich
  • Extracellular signal-regulated kinase, sequences, and methods of production and use
    Patent number: 5459036
    Abstract: The present invention relates, in general, to an extracellular signal regulated kinase, ERK-5. In particular, the present invention relates to nucleic acid molecules coding for ERK-5; ERK-5 polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antisense ERK-5 nucleic acid constructs; antibodies having binding affinity to an ERK-5 polypeptide; hybridomas containing the antibodies; nucleic acid probes for the detection of ERK-5 nucleic acid; a method of detecting ERK-5 nucleic acid or polypeptide in a sample; kits containing nucleic acid probes or antibodies; a method of detecting a compound capable of binding to ERK-5 or a fragment thereof; a method of detecting an agonist or antagonist of ERK-5 activity; a method of agonizing or antagonizing ERK-5 associated activity in a mammal; and a pharmaceutical composition comprising an ERK-5 agonist or antagonist.
    Type: Grant
    Filed: March 19, 1993
    Date of Patent: October 17, 1995
    Assignee: Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V.
    Inventors: Cornelia Lechner, Niels P. H. Moller, Axel Ullrich
  • Peptides and compositions
    Patent number: 4816441
    Abstract: Peptides of the formula R.sup.1 -His-Asp-Glu-Ala-R wherein R.sup.1 is Ala-Gln, and R is a polypeptide residue with up to 50 amino acid residues, and wherein one, more or all of the amino acid residues in R.sup.1 and/or R independently may be omitted, can be used to augment cell mediated cytotoxicity and thereby to treat cancers and viral infections. These peptides may be prepared by proteolytic digestion of Staphylococcus aureus protein A, as well as by protein synthesis, recombinant DNA methods or any other methods known in the art.
    Type: Grant
    Filed: November 14, 1986
    Date of Patent: March 28, 1989
    Assignee: Novo Industri A/S
    Inventors: Jesper Zeuthen, Lars Thim, Niels P. H. Moller