Abstract: An oral hygiene device in the form of a toothbrush 10 comprises a handle section 12, a cartridge 14 containing a cleaning composition held under gas pressure, an actuating mechanism 16 and a head section 18. The cartridge has a discharge opening at a front end thereof, which includes a control valve 26 comprising a valve stem 27. The actuating mechanism 16 includes a plunger 40 and a lever formation 38 which acts on the plunger. The lever formation is acted upon by a hand-operated actuating button 58 for dispensing the plunger rearwardly for depressing the valve stem 27 for releasing cleaning composition from the cartridge causing the cleaning composition to be conveyed under gas pressure along passage 48 of the valve stem and into passages 46, 32, 37 and 29 where it is discharged via opening 31 at a distal end of the head section 18 onto bristles 28.

Abstract: A method for reducing idle mode power consumption is disclosed. An idle mode is entered. A neighboring base station is selected. If the selected neighboring base station is assigned a high-frequency monitoring mode, a signal strength of the neighboring base station is measured. A low-frequency monitoring mode is assigned to the selected neighboring base station if the signal strength of the selected neighboring base station has been below a power threshold for longer than a time threshold. Other aspects, embodiments, and features are also claimed and described.

Abstract: A method for receiving cell broadcast messages is described. The method includes communicating with a first cell. The method also includes switching to communicating with a second cell. A cell broadcast channel is read after switching cells. The method further includes switching from a dedicated mode to a packet idle mode. The cell broadcast channel is reread once after switching from a dedicated mode to a packet idle mode. Other aspects, embodiments and features are also claimed and described.

Abstract: Apparatus and methods are disclosed to provide for a multi-SIM wireless user equipment configured for block-level, or slot-level tune-away operations enabling simultaneous communication with a plurality of channels. The first and second channels may correspond to different RANs, each of which the user equipment may subscribe to as corresponding to information in a plurality of SIMs at the user equipment. In other examples, the first and second channels may correspond to different cells within a single RAN. In either case, the tune-away operations disclosed provide for reduced data loss at the first channel and in some examples improved communication performance at the second channel. Other aspects, embodiments, and features are also claimed and described.

Abstract: A method for receiving cell broadcast messages is described. The method includes communicating with a first cell. The method also includes switching to communicating with a second cell. A cell broadcast channel is read after switching cells. The method further includes switching from a dedicated mode to a packet idle mode. The cell broadcast channel is reread once after switching from a dedicated mode to a packet idle mode. Other aspects, embodiments and features are also claimed and described.

Abstract: A method for receiving cell broadcast messages is described. The method includes communicating with a first cell. The method also includes switching to communicating with a second cell. A cell broadcast channel is read after switching cells. The method further includes switching from a dedicated mode to a packet idle mode. The cell broadcast channel is reread once after switching from a dedicated mode to a packet idle mode. Other aspects, embodiments and features are also claimed and described.

Abstract: A method for receiving cell broadcast messages is described. The method includes communicating with a first cell. The method also includes switching to communicating with a second cell. A cell broadcast channel is read after switching cells. The method further includes switching from a dedicated mode to a packet idle mode. The cell broadcast channel is reread once after switching from a dedicated mode to a packet idle mode. Other aspects, embodiments and features are also claimed and described.

Abstract: A method for receiving cell broadcast messages is described. The method includes communicating with a first cell. The method also includes switching to communicating with a second cell. A cell broadcast channel is read after switching cells. The method further includes switching from a dedicated mode to a packet idle mode. The cell broadcast channel is reread once after switching from a dedicated mode to a packet idle mode. Other aspects, embodiments and features are also claimed and described.

Abstract: A method for receiving cell broadcast messages is described. The method includes communicating with a first cell. The method also includes switching to communicating with a second cell. A cell broadcast channel is read after switching cells. The method further includes switching from a dedicated mode to a packet idle mode. The cell broadcast channel is reread once after switching from a dedicated mode to a packet idle mode. Other aspects, embodiments and features are also claimed and described.

Abstract: A method for receiving cell broadcast messages is described. The method includes communicating with a first cell. The method also includes switching to communicating with a second cell. A cell broadcast channel is read after switching cells. The method further includes switching from a dedicated mode to a packet idle mode. The cell broadcast channel is reread once after switching from a dedicated mode to a packet idle mode. Other aspects, embodiments and features are also claimed and described.

Abstract: Apparatus and methods are disclosed to provide for a multi-SIM wireless user equipment configured for block-level, or slot-level tune-away operations enabling simultaneous communication with a plurality of channels. The first and second channels may correspond to different RANs, each of which the user equipment may subscribe to as corresponding to information in a plurality of SIMs at the user equipment. In other examples, the first and second channels may correspond to different cells within a single RAN. In either case, the tune-away operations disclosed provide for reduced data loss at the first channel and in some examples improved communication performance at the second channel. Other aspects, embodiments, and features are also claimed and described.

Abstract: The described aspects include a user equipment (UE) apparatus and corresponding method of communicating with multiple networks using multiple subscriptions. The UE can establish a call in a first network related to a first subscription over a transceiver. During the call, the UE autonomously tunes the transceiver to a frequency of a second network related to a second subscription within a defined gap during the call. The UE can monitor one or more channels in the second network during the defined gap for one or more idle-mode signals.

Abstract: A method for receiving cell broadcast messages is described. The method includes communicating with a first cell. The method also includes switching to communicating with a second cell. A cell broadcast channel is read after switching cells. The method further includes switching from a dedicated mode to a packet idle mode. The cell broadcast channel is reread once after switching from a dedicated mode to a packet idle mode. Other aspects, embodiments and features are also claimed and described.

Abstract: An improved process for the manufacture of (E)-7-[4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfony)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium salt, Formula (1), which is useful for the production of a pharmaceutical useful in the treatment of, inter alia, hypercholesterolemia, hyperlipoproteinemia and atherosclerosis, is described.

Abstract: A method for reducing idle mode power consumption is disclosed. An idle mode is entered. A neighboring base station is selected. If the selected neighboring base station is assigned a high-frequency monitoring mode, a signal strength of the neighboring base station is measured. A low-frequency monitoring mode is assigned to the selected neighboring base station if the signal strength of the selected neighboring base station has been below a power threshold for longer than a time threshold. Other aspects, embodiments, and features are also claimed and described.

Abstract: An improved process for the manufacture of (E)-7-[4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfony)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium salt, Formula (1), which is useful for the production of a pharmaceutical useful in the treatment of, inter alia, hypercholesterolemia, hyperlipoproteinemia and atherosclerosis, is described.

Abstract: The present invention facilitates in silico evaluation of molecules for biological activity by providing a computer-based method to predict whether oligonucleotides may possess biological activity and the efficacy of the biological activity based on the three-dimensional structure and charge characteristics of the oligonucleotides. Biological activities include, but are not limited to, cellular proliferation, induction of cell cycle arrest and apoptosis.

Abstract: The present invention provides a composition and method comprising a 2-20 base 3?-OH, 5?-OH synthetic oligonucleotide (sequence) selected from the group consisting of (GxTy)n, (TyGx)n, a(GxTy)n, a(TyGx)n, (GxTy)nb, (TyGx)nb, a(GxTy)nb, a(TyGx)nb, wherein x and y is an integer between 1 and 7, n is an integer between 1 and 12, a and b are one or more As, Cs, Gs or Ts aid wherein the sequence induces a response selected from the group consisting of induction of cell cycle arrest, inhibition of proliferation, activation of caspases and induction of apoptosis in cancer cells and production of cytokines by immune system cells.

Abstract: The present invention provides compositions comprising a 3?-OH, 5?-OH, chemically unmodified, synthetic phosphodiester nucleotide sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, and SEQ ID NO: 4, and a pharmaceutically acceptable carrier, wherein the compositions are useful to induce differentiation of cells or to stimulate differentiation or production of pluripotent cells. The present invention provides methods of using these compositions to induce differentiation of pluripotent cells, including bone marrow derived cells, and to treat disease associated with insufficient differentiation of cells in animals and humans, including but not limited to leukemia, lymphoma, non-malignant blood disorders such as hemoglobinopathies, sickle cell disease, myelodysplastic syndrome, pancytopenia, anemia, thrombocytopenia and leukopenia.

Abstract: A process for the preparation of a salt of 5-phenylpentanoyl-(S)-arginyl-(S)-alanyl-{(S)-2-[(R)-3-amino-2-oxopyrrolidin-1-yl]propionyl}-(S)-alanyl-(S)-arginyl-(S)-alanyl-4-aminophenylacetamide (SEQ ID NO: 1) which comprises deprotection of a compound of the formula II or a salt thereof: wherein Pg and R1 are defined in the description. Also claimed are intermediates used in the process and the processes for the preparation of the intermediates.