Patents by Inventor Nikolai A. Kley

Nikolai A. Kley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC TARGETING OF NON-CELLULAR STRUCTURES
    Publication number: 20210238264
    Abstract: The present invention relates, in part, to chimeric proteins that bind a non-cellular structure and their use as therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the chimeric proteins and their use in the treatment of various diseases.
    Type: Application
    Filed: May 12, 2017
    Publication date: August 5, 2021
    Inventors: Nikolai KLEY, Jan TAVERNIER, Leander HUYGHE, Anje CAUWELS
  • TARGETED ENGINEERED INTERFERON AND USES THEREOF
    Publication number: 20210230291
    Abstract: The present invention relates, in part, to chimeric proteins comprising consensus interferon, or a variant thereof, and their use as therapeutic agents.
    Type: Application
    Filed: December 24, 2020
    Publication date: July 29, 2021
    Inventors: Nikolai KLEY, Lennart ZABEAU, Jan TAVERNIER
  • BISPECIFIC SIGNALING AGENTS AND USES THEREOF
    Publication number: 20210139586
    Abstract: The present invention relates, in part, to bispecific chimeric proteins that find use in various immunotherapies based on various properties, including, for example, a dual immune cell recruitment and immune signal delivery function.
    Type: Application
    Filed: December 21, 2020
    Publication date: May 13, 2021
    Inventors: Nikolai KLEY, Jan TAVERNIER, Sandra VAN LINT, Anje CAUWELS
  • Clec9A binding agents
    Patent number: 11001631
    Abstract: The present invention relates, in part, to agents that bind Clec9A and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the Clec9A binding agents and their use in the treatment of various diseases.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: May 11, 2021
    Assignees: Orionis Biosciences BV, VIB VZW, Universiteit Gent
    Inventors: Jan Tavernier, Nikolai Kley, Anje Cauwels, Sarah Gerlo
  • Bispecific signaling agents and uses thereof
    Patent number: 10988538
    Abstract: The present invention relates, in part, to bispecific chimeric proteins that find use in various immunotherapies based on various properties, including, for example, a dual immune cell recruitment and immune signal delivery function.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: April 27, 2021
    Assignees: Orionis Biosciences BV, VIB VZW, Universiteit Gent
    Inventors: Nikolai Kley, Jan Tavernier, Sandra Van Lint, Anje Cauwels
  • Targeted engineered interferon and uses thereof
    Patent number: 10906985
    Abstract: The present invention relates, in part, to chimeric proteins comprising consensus interferon, or a variant thereof, and their use as therapeutic agents.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: February 2, 2021
    Assignees: Orionis Biosciences, Inc., Orionis Biosciences BV
    Inventors: Nikolai Kley, Lennart Zabeau, Jan Tavernier
  • FIBROBLAST BINDING AGENTS AND USE THEREOF
    Publication number: 20210023167
    Abstract: The present invention relates, in part, to agents that bind fibroblast activation protein (FAP) and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the FAP binding agents and their use in the treatment of various diseases.
    Type: Application
    Filed: February 5, 2019
    Publication date: January 28, 2021
    Inventors: Nikolai KLEY, Jan TAVERNIER, Anje CAUWELS
  • BI-FUNCTIONAL PROTEINS AND CONSTRUCTION THEREOF
    Publication number: 20210024631
    Abstract: The present invention relates, in part, to Fc-based chimeric protein complexes and their use as therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the Fc-based chimeric protein complexes and their use in the treatment of various diseases.
    Type: Application
    Filed: March 28, 2019
    Publication date: January 28, 2021
    Inventors: Nikolai KLEY, Erik DEPLA, Lennart ZABEAU, Jan TAVERNIER
  • CLEC9A BINDING AGENTS AND USE THEREOF
    Publication number: 20210024637
    Abstract: The present invention relates, in part, to agents that bind Clec9A and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the Clec9A binding agents and their use in the treatment of various diseases.
    Type: Application
    Filed: August 8, 2018
    Publication date: January 28, 2021
    Inventors: Nikolai KLEY, Jan TAVERNIER, Lennart ZABEAU, Erik DEPLA
  • PD-1 AND PD-L1 BINDING AGENTS
    Publication number: 20200407448
    Abstract: The present invention relates, in part, to agents that bind PD-1 or PD-L1 and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the PD-1 or PD-L1 binding agents and their use in the treatment of various diseases.
    Type: Application
    Filed: August 8, 2018
    Publication date: December 31, 2020
    Inventors: Nikolai KLEY, Jan TAVERNIER, Lennart ZABEAU, Erik DEPLA
  • XCR1 BINDING AGENTS AND USES THEREOF
    Publication number: 20200354424
    Abstract: The present invention relates, in part, to agents that bind XCR1 and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the XCR1 binding agents and their use in the treatment of various diseases.
    Type: Application
    Filed: January 28, 2019
    Publication date: November 12, 2020
    Inventors: Nikolai KLEY, Jan TAVERNIER
  • THERAPEUTIC INTERFERON ALPHA 1 PROTEINS
    Publication number: 20200308244
    Abstract: The present invention relates, in part, to chimeric proteins or chimeric protein complexes, such as Fc-based chimeric protein complexes, comprising interferon alpha 1, or a variant thereof, and their use as therapeutic agents.
    Type: Application
    Filed: March 27, 2020
    Publication date: October 1, 2020
    Applicant: Orionis Biosciences BV
    Inventors: Nikolai KLEY, Erik DEPLA, Lennart ZABEAU, Jan TAVERNIER
  • CD8 BINDING AGENTS
    Publication number: 20200231674
    Abstract: The present invention relates, in part, to agents that bind CD8 and their use as therapeutic and diagnostic agents. The present invention further relates to pharmaceutical compositions comprising the CD8 binding agents and their use in the treatment of various diseases, including, for example, cancers.
    Type: Application
    Filed: August 8, 2018
    Publication date: July 23, 2020
    Inventors: Nikolai KLEY, Jan TAVERNIER, Lennart ZABEAU, Erik DEPLA
  • TARGETED CHIMERIC PROTEINS AND USES THEREOF
    Publication number: 20200087411
    Abstract: The present invention relates, in part, to chimeric proteins comprising at least one targeting moiety that recognizes and binds SIRP1? and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the chimeric proteins and their use in the treatment of various diseases.
    Type: Application
    Filed: February 5, 2018
    Publication date: March 19, 2020
    Inventors: Nikolai KLEY, Jan TAVERNIER
  • TARGETED ENGINEERED INTERFERON AND USES THEREOF
    Publication number: 20200071414
    Abstract: The present invention relates, in part, to chimeric proteins comprising consensus interferon, or a variant thereof, and their use as therapeutic agents.
    Type: Application
    Filed: February 5, 2018
    Publication date: March 5, 2020
    Inventors: Nikolai KLEY, Lennart ZABEAU, Jan TAVERNIER
  • TARGETED MUTANT INTERFERON-GAMMA AND USES THEREOF
    Publication number: 20200055912
    Abstract: The present invention relates, in part, to chimeric proteins comprising mutant interferon-? and their use as therapeutic agents.
    Type: Application
    Filed: October 24, 2017
    Publication date: February 20, 2020
    Inventors: Nikolai KLEY, Jan TAVERNIER, Frank PEELMAN, Lennart ZABEAU
  • BISPECIFIC SIGNALING AGENTS AND USES THEREOF
    Publication number: 20190367604
    Abstract: The present invention relates, in part, to bispecific chimeric proteins that find use in various immunotherapies based on various properties, including, for example, a dual immune cell recruitment and immune signal delivery function.
    Type: Application
    Filed: February 6, 2017
    Publication date: December 5, 2019
    Inventors: Nikolai KLEY, Jan TAVERNIER, Sandra VAN LINT, Anje CAUWELS
  • CLEC9A BINDING AGENTS
    Publication number: 20190352406
    Abstract: The present invention relates, in part, to agents that bind Clec9A and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the Clec9A binding agents and their use in the treatment of various diseases.
    Type: Application
    Filed: February 6, 2017
    Publication date: November 21, 2019
    Inventors: Jan TAVERNIER, Nikolai KLEY, Anje CAUWELS, Sarah GERLO
  • TARGETED MUTANT INTERFERON-BETA AND USES THEREOF
    Publication number: 20190194284
    Abstract: The present invention relates, in part, to chimeric proteins comprising mutant interferon-? and their use as therapeutic agents.
    Type: Application
    Filed: May 12, 2017
    Publication date: June 27, 2019
    Inventors: Nikolai KLEY, Jan TAVERNIER, Frank PEELMAN
  • BI-FUNCTIONAL CHIMERIC PROTEINS AND USES THEREOF
    Publication number: 20190144553
    Abstract: The present invention relates, in part, to targeted chimeric proteins with beneficial therapeutic effects, including, for example, effects mediated by mutant forms of soluble agents that are part of the chimeric proteins. Pharmaceutical compositions comprising the chimeric proteins are also provided. The present invention finds use in the treatment of various disease and disorders.
    Type: Application
    Filed: November 11, 2016
    Publication date: May 16, 2019
    Inventors: Nikolai KLEY, Jan TAVERNIER, Leander HUYGHE, Thomas WUEEST