Patents by Inventor Nikolaus Wenger
Nikolaus Wenger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11202911Abstract: The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment.Type: GrantFiled: March 4, 2019Date of Patent: December 21, 2021Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Gregoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Silvestro Micera, Marco Bonizzato
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Patent number: 10981004Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.Type: GrantFiled: July 10, 2019Date of Patent: April 20, 2021Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Jocelyne Bloch, Grégoire Courtine, Nikolaus Wenger, Silvestro Micera, Marco Capogrosso
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Publication number: 20190344075Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.Type: ApplicationFiled: July 10, 2019Publication date: November 14, 2019Inventors: Jocelyne BLOCH, Grégoire COURTINE, Nikolaus WENGER, Silvestro MICERA, Marco CAPOGROSSO
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Publication number: 20190269917Abstract: The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment.Type: ApplicationFiled: March 4, 2019Publication date: September 5, 2019Inventors: Gregoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Silvestro Micera, Marco Bonizzato
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Patent number: 10391309Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.Type: GrantFiled: December 21, 2016Date of Patent: August 27, 2019Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Jocelyne Bloch, Grégoire Courtine, Nikolaus Wenger, Silvestro Micera, Marco Capogrosso
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Patent number: 10279177Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.Type: GrantFiled: August 4, 2017Date of Patent: May 7, 2019Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Jocelyne Bloch, Grégoire Courtine, Nikolaus Wenger, Silvestro Micera, Marco Capogrosso
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Patent number: 10279167Abstract: The present disclosure provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising electrodes for applying to a subject neuromodulation with adjustable stimulation parameters, the electrodes being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with the electrodes said and providing the electrodes with new stimulation parameters, with minimum delay. The system of the disclosure improves consistency of walking in a subject with a neuromotor impairment.Type: GrantFiled: September 27, 2017Date of Patent: May 7, 2019Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Grégoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Silvestro Micera, Marco Bonizzato
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Patent number: 10265525Abstract: The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment.Type: GrantFiled: October 29, 2014Date of Patent: April 23, 2019Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Gregoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Silvestro Micera, Marco Bonizzato
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Publication number: 20180093093Abstract: The present disclosure provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the disclosure improves consistency of walking in a subject with a neuromotor impairment.Type: ApplicationFiled: September 27, 2017Publication date: April 5, 2018Inventors: Grégoire COURTINE, Nikolaus WENGER, Eduardo Martin MORAUD, Silvestro MICERA, Marco BONIZZATO
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Publication number: 20170354819Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.Type: ApplicationFiled: August 4, 2017Publication date: December 14, 2017Inventors: Jocelyne BLOCH, Grégoire COURTINE, Nikolaus WENGER, Silvestro MICERA, Marco CAPOGROSSO
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Publication number: 20170173326Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.Type: ApplicationFiled: December 21, 2016Publication date: June 22, 2017Inventors: Jocelyne BLOCH, Grégoire COURTINE, Nikolaus WENGER, Silvestro MICERA, Marco CAPOGROSSO
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Publication number: 20160279418Abstract: The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment.Type: ApplicationFiled: October 29, 2014Publication date: September 29, 2016Applicant: Ecole Polytechnique Federale de Lausanne (EPFL)Inventors: Gregoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Silvestro Micera, Marco Bonizzato