Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.

Abstract: Techniques are disclosed for accelerating online certificate status protocol (OCSP) response distribution to relying parties using a content delivery network (CDN). A certificate authority generates updated OCSP responses for OCSP responses cached in the CDN that are about to expire. In addition, the certificate authority pre-generates cache keys in place of CDNs generating the keys. The certificate authority sends the OCSP responses and the cache keys in one transaction, and the CDN, in turn, serves requests for the OCSP responses using the cache keys. For new certificates, a private CDN is pre-populated with an OCSP response for a certificate concurrent with that certificate being issued. Doing so effectively uses the PCDN as an origin server for OCSP responses, reducing CA infrastructure needs.

Abstract: A gas diffuser including a grid of aeration pipes spaced apart and in parallel alignment within a horizontal plane is provided. The aeration pipes have improved discharge hole placement along their lengths and around their circumferences to provide improved performance and reduced fouling of membrane filtration systems associated therewith.

Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.

Abstract: A gas diffuser comprises a grid of aeration pipes spaced apart and in parallel alignment with each other within a common horizontal plane and a manifold in fluid communication with the aeration pipes. A given aeration pipe (12) includes: a length (L) extending between two ends and defining an axis (Z), a hydrodynamic diameter (Dh),an elliptical cross-sectional area defining a vertical plane comprising a vertical (Y) and horizontal (X) axis intersecting through a center (C) which are perpendicular to axis (Z), an outer circumference defined by a first arc (20) comprising 30° located below the (X) axis and bisected by the (Y) axis, and a second arc (22) comprising 330° which is non-overlapping with the first arc (20.

Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.

Abstract: A polypeptide comprising a preS1 region of hepatitis B virus (HBV), or a fragment thereof, and/or the preS2 region of HBV or a fragment thereof, and methods of use to inhibit virus infection are disclosed. A lentivirus comprising hepatitis B virus (HBV) envelope proteins, or a fragment thereof, and/or the L envelope protein of HBV and/or the M envelope protein of HBV or a fragment thereof, and/or the S envelope protein of HBV or a fragment thereof, and methods of use of this lentivirus HBV pseudovirus as a gene therapy to target hepatocytes for the administration of therapeutic agents are also disclosed.

Abstract: The present invention relates to methods for enrichment of antigen-specific plasmablasts. The methods are useful for the identification of antibodies, including rare antibodies which recognize more than one antigen.

Abstract: A polypeptide comprising a preS1 region of hepatitis B virus (HBV), or a fragment thereof, and/or the preS2 region of HBV or a fragment thereof, and methods of use to inhibit virus infection are disclosed. A lentivirus comprising hepatitis B virus (HBV) envelope proteins, or a fragment thereof, and/or the L envelope protein of HBV and/or the M envelope protein of HBV or a fragment thereof, and/or the S envelope protein of HBV or a fragment thereof, and methods of use of this lentivirus HBV pseudovirus as a gene therapy to target hepatocytes for the administration of therapeutic agents are also disclosed.