Abstract: The present invention relates generally to the fields of oncology, virology and immunotherapy. More particularly, it concerns the use of poxviruses, specifically the replication competent attenuated vaccinia virus with deletion of thymidine kinase (VC-TK?) with and without the expression of human Flt3L or GM-CSF as oncolytic and immunotherapy. The foregoing poxviruses can also be used in combination with immune checkpoint blocking agents. The foregoing poxviruses can also be inactivated via Heat or UV-treatment and the inactivated virus can be used as immunotherapy either alone or in combination with immune checkpoint blocking agents.

Abstract: A communication system, a transmitter, and a communication method. The communication system includes M transmitters, N receivers, and an optical switch network. Both N and M are positive integers greater than 1. The optical switch network includes one or more optical switches. A plurality of optical paths are configured in the optical switch network. When the transmitter communicates with the receiver, the transmitter can determine, from the plurality of optical paths, a target optical path from a source communication node to a destination communication node. After the optical switch network receives a target optical signal sent by the transmitter, the optical switch directly sends the target optical signal to the receiver based on the target optical path.

Abstract: A method for preparing Mg-RE alloys with high strength and ductility using selective laser melting (SLM) additive manufacturing technology includes the following steps of: A. preparing Mg-RE-(Zn)—Zr pre-alloyed spherical powder by gas atomization; B. molding the Mg-RE-(Zn)—Zr pre-alloyed spherical powder using SLM to obtain the Mg-RE alloys with high strength and ductility; and C. conducting heat treatment on the Mg-RE alloys prepared in step B: solid solution+aging treatment or only aging treatment The method adjusts and controls microstructure and mechanical properties of the alloys by adjusting and controlling process parameters of SLM (laser power, scanning speed, hatch spacing, spot diameter, layer thickness, interlayer rotation angle, substrate preheating temperature, partition width and overlapping area width) and process parameters of subsequent heat treatment (temperature and time) to prepare the Mg-RE-(Zn)—Zr alloys with high strength and ductility using SLM process for the first time.

Abstract: A method for viewing angle adjustment according to one embodiment may include: displaying a first image in a virtual scene at a first viewing angle when the terminal is at a first position; detecting a terminal position change from the first position to a second position; determining a viewing angle adjustment sensitivity based on one of: whether there is a press operation on a region of a touchscreen of the terminal; or whether a displaying mode of the virtual scene is a panorama mode; determining an angle variation reflecting viewing angle change based on: a position variation from the first position to the second position, and the viewing angle adjustment sensitivity; determining a second view angle based on the angle variation and the first viewing angle; and displaying a second image in the virtual scene at the second viewing angle when the terminal is located at the second position.

Abstract: Aspects of the invention include micro-vesicles comprising cargo RNA. In some instances, the micro-vesicles include: (1) a TSG101 associating protein stably associated with a ribonucleic-acid-binding protein (RNA-binding protein); and (2) at least one cargo RNA complex that includes an RNA bound non-covalently to the RNA-binding protein and a cargo prodrug RNA component. Also provided are methods of making and using the micro-vesicles, e.g., in the treatment of disease conditions.

Abstract: An optical distribution network, an optical network system, a splitter, and a method for identifying a port of the splitter are provided. The optical distribution network includes a splitter, a first optical filter, and a first power change assembly. The splitter includes at least two output ports, each output port corresponds to at least one first optical filter, different output ports correspond to different first optical filters, and center wavelengths of detection light that the different first optical filters allow to pass through or do not allow to pass through are different. Each output port of each splitter in an Nth-level splitter corresponds to the first power change assembly, and the first power change assembly is configured to change a power of first service light based on received first detection light.

Abstract: A distributed database system maintains a database including a data shard for which a primary computing node is responsible. The primary computing node identifies a data storage plan for the data shard. The plan identifies a file subset of data storage files of the shard to be merged into a larger data storage file, and a node subset of computing nodes of the system that subscribe to the data shard. The primary node identifies which computing nodes of the node subset each have sufficient computing resources to execute the plan, as candidate computing nodes. The primary node identifies which files of the file subset each candidate computing node locally caches. The primary node selects one candidate computing node to execute the plan, based on the files of the file subset that each candidate computing node locally caches. The primary node causes the selected candidate computing node to execute the plan.

Abstract: A WSS is provided. The WSS includes a first common port, a second common port, a grating, a spatial light modulator, and a plurality of branch ports. The first common port is configured to receive a first-band optical signal, and the second common port is configured to receive a second-band optical signal. The grating is configured to perform wavelength demultiplexing on the first-band optical signal and the second-band optical signal, to output a plurality of first optical signals, where the first optical signals are optical signals of a single wavelength.

Abstract: Embodiments of the present invention disclose an optical signal transmission system and an optical signal transmission method. A specific solution is as follows: a first coherent transceiver is configured to: convert N channels of downlink data into N modulating signals, convert the N modulating signals into a first wavelength division multiplexing signal, and send the first wavelength division multiplexing signal to an optical transport unit; the optical transport unit is configured to: receive the first wavelength division multiplexing signal, convert the first wavelength division multiplexing signal into N second optical signals, and correspondingly send the N second optical signals to N second coherent transceivers; and one of the N second coherent transceivers is configured to: receive the N second optical signals, and process the N second optical signals to obtain information in downlink data carried in the N second optical signals.

Abstract: One example display apparatus includes a multi-focus image generation device with a plurality of different focal lengths, configured to generate a first plurality of images, where focal planes of the first plurality of images are located in different positions. The example display apparatus includes a light diffuser screen, disposed on an image plane of the multi-focus image generation device, and configured to receive the first plurality of images, and diffuse light beams of the first plurality of images to generate a second plurality of images. The example display apparatus includes an optical image device, configured to image light beams of the second plurality of images to form a third plurality of images with different imaging distances.

Abstract: An optical time-domain reflectometer (OTDR), where a laser emitting apparatus of the OTDR outputs a first optical signal in a first time period. A signal modulation apparatus of the OTDR generates a pulse signal based on the first optical signal, and outputs the pulse signal to an optical fiber in a second time period, where the first time period includes the second time period. A receiver of the OTDR receives a scattered signal from the optical fiber, where a frequency of the scattered signal is the same as a frequency of the first optical signal. Then, the laser emitting apparatus outputs a second optical signal in a third time period, where a frequency of the second optical signal is different from the frequency of the first optical signal. The second optical signal is used as a local oscillator signal to implement coherent detection in the receiver.

Abstract: Example optical amplification apparatus and example signal amplification methods are provided. One example optical amplification apparatus is connected to an optical fiber. The optical amplification apparatus includes a first pump laser and a first gain medium. The first pump laser is configured to emit first pump light. The first gain medium is configured to receive the first pump light and first multi-channel optical signals from the optical fiber; and perform gain amplification on the first multi-channel optical signals based on the first pump light, where the first pump light overlaps each of the first multi-channel optical signals in the first gain medium.

Abstract: An optical amplifier includes at least two stages of optical amplifier systems, an optical switch, a dynamic gain equalizer (DGE), and a control circuit. An input end of the optical switch is separately coupled to an output end of a first-stage optical amplifier system and an output end of a second-stage optical amplifier system, and an output end of the optical switch is separately coupled to an input end of the second-stage optical amplifier system and an input end of the DGE. The optical switch is configured to set at least two gain modes of the optical amplifier. The control circuit is configured to adjust an attenuation spectrum of the DGE based on the at least two gain modes set by the optical switch. The DGE is configured to perform, based on an adjusted attenuation spectrum, power attenuation processing on signals of different wavelengths in a received optical signal.

Abstract: A frequency offset processing method, apparatus, and a storage medium, where the method includes: determining a frequency offset of a preset channel in a wavelength selective switch (WSS); determining a correspondence between a frequency offset and a wavelength or a correspondence between a frequency offset and a pixel position based on the frequency offset of the preset channel; and determining a frequency offset of a traffic channel according to the determined correspondence.

Abstract: Embodiments of the present invention disclose an optical signal transmission system and an optical signal transmission method. A specific solution is as follows: a first coherent transceiver is configured to: convert N channels of downlink data into N modulating signals, convert the N modulating signals into a first wavelength division multiplexing signal, and send the first wavelength division multiplexing signal to an optical transport unit; the optical transport unit is configured to: receive the first wavelength division multiplexing signal, convert the first wavelength division multiplexing signal into N second optical signals, and correspondingly send the N second optical signals to N second coherent transceivers; and one of the N second coherent transceivers is configured to: receive the N second optical signals, and process the N second optical signals to obtain information in downlink data carried in the N second optical signals.

Abstract: Embodiments of the present invention disclose an optical signal transmission system and an optical signal transmission method. A specific solution is as follows: a first coherent transceiver is configured to: convert N channels of downlink data into N modulating signals, convert the N modulating signals into a first wavelength division multiplexing signal, and send the first wavelength division multiplexing signal to an optical transport unit; the optical transport unit is configured to: receive the first wavelength division multiplexing signal, convert the first wavelength division multiplexing signal into N second optical signals, and correspondingly send the N second optical signals to N second coherent transceivers; and one of the N second coherent transceivers is configured to: receive the N second optical signals, and process the N second optical signals to obtain information in downlink data carried in the N second optical signals.

Abstract: A frequency offset processing method, apparatus, and a storage medium, where the method includes: determining a frequency offset of a preset channel in a wavelength selective switch (WSS); determining a correspondence between a frequency offset and a wavelength or a correspondence between a frequency offset and a pixel position based on the frequency offset of the preset channel; and determining a frequency offset of a traffic channel according to the determined correspondence.

Abstract: Aspects of the present disclosure include methods of reducing the deleterious impact of a target gene in a cell, such as the deleterious activity of a mutant extended nucleotide repeat (NR) containing target gene in a cell, by contacting the cell with an effective amount of an enantiomeric tetrahydrocarbazolamine compound. The deleterious activity (e.g., toxicity and/or dis-functionality of products encoded thereby) of a mutant extended NR containing target gene may be reduced, e.g., by reducing (and in some instances differentially, including selectively, reducing) the production or activity of toxic expression products (e.g., RNA or protein) encoded by the target gene. Kits and compositions for practicing the subject methods are also provided.

Abstract: Embodiments of the present invention disclose an optical signal transmission system and an optical signal transmission method. A specific solution is as follows: a first coherent transceiver is configured to: convert N channels of downlink data into N modulating signals, convert the N modulating signals into a first wavelength division multiplexing signal, and send the first wavelength division multiplexing signal to an optical transport unit; the optical transport unit is configured to: receive the first wavelength division multiplexing signal, convert the first wavelength division multiplexing signal into N second optical signals, and correspondingly send the N second optical signals to N second coherent transceivers; and one of the N second coherent transceivers is configured to: receive the N second optical signals, and process the N second optical signals to obtain information in downlink data carried in the N second optical signals.

Abstract: Aspects of the invention include methods of reducing the deleterious activity of a mutant extended nucleotide repeat (NR) containing target gene in a cell by contacting the cell with an effective amount of a nucleoside agent, as well as compositions used in such methods. The deleterious activity (e.g., toxicity and/or dis-functionality of products encoded thereby) of a mutant extended NR containing target gene may be reduced in a variety of different ways, e.g., by reducing (and in some instances differentially, including selectively, reducing) the production or activity of toxic expression products (e.g., RNA or protein) encoded by the target gene. Kits and compositions for practicing the subject methods are also provided.