Abstract: A depth estimation from focus method and system includes receiving input image data containing focus information, generating an intermediate attention map by an AI model, normalizing the intermediate attention map into a depth attention map via a normalization function, and deriving expected depth values for the input image data containing focus information from the depth attention map. The AI model for depth estimation can be trained unsupervisedly without ground truth depth maps. The AI model of some embodiments is a shared network estimating a depth map and reconstructing an AiF image from a set of images with different focus positions.