Patents by Inventor Ning-Sun Yang

Ning-Sun Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11207289
    Abstract: A method for suppressing tumor metastasis, in which an effective amount of a compound of formula (I) is administered to a subject in need thereof. Also disclosed is a method of treating cancer, in which an effective amount of a chemotherapy agent and an effective amount of a compound of formula (I) is administered to a subject in need thereof. Further disclosed are pharmaceutical compositions for suppressing tumor metastasis and for treating cancer, each of the compositions containing a compound of formula (I).
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: December 28, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Ning-Sun Yang, Yueh-Hsiung Kuo, Shu-Yi Yin, Yung-Hsiang Chen
  • Publication number: 20200289454
    Abstract: A method for suppressing tumor metastasis, in which an effective amount of a compound of formula (I) is administered to a subject in need thereof. Also disclosed is a method of treating cancer, in which an effective amount of a chemotherapy agent and an effective amount of a compound of formula (I) is administered to a subject in need thereof. Further disclosed are pharmaceutical compositions for suppressing tumor metastasis and for treating cancer, each of the compositions containing a compound of formula (I).
    Type: Application
    Filed: March 17, 2017
    Publication date: September 17, 2020
    Applicants: ACADEMIA, Sinica
    Inventors: Ning-Sun Yang, Yueh-Hsiung Kuo, Shu-Yi Yin, Yung-Hsiang Chen
  • Publication number: 20170360863
    Abstract: A pharmacological composition for use in inhibiting differentiation, functional activities, and population of granulo-cytic myeloid-derived suppressor cells (gMDSCs) and/or suppressing, tumor metastasis in a subject in need thereof is disclosed. The composition comprises a therapeutically effective amount of Bidens pilosa extract, or more than one polyacetylenic compounds purified or isolated from the B. pilosa extract, and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: December 9, 2015
    Publication date: December 21, 2017
    Inventors: Ning-Sun YANG, Wen-Chi WEI, Sheng-Yen LIN, Pei-Wen HSIAO, Yet-Ren CHEN
  • Patent number: 8530513
    Abstract: The invention relates to use of a diterpene from a coral, excavatolide B, or an analogue thereof for treating a disease associated with inducible nitric oxide synthase, cyclooxygenase-2 and/or matrix metalloproteinase. The invention also relates to use of a diterpene from a coral, excavatolide B, and an analogue thereof for treating a disease associated with TNF-? and/or IL-6 over-expression.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: September 10, 2013
    Assignee: National Sun Yat-Sen University
    Inventors: Jyh-Horng Sheu, Ning-Sun Yang, Wen-Chi Wei, Chiung-Yao Huang
  • Patent number: 8048455
    Abstract: Disclosed are extracts, compositions, and methods for treating cancer and inflammatory disorders. Also disclosed are methods for preparing extracts or compounds for treating the disorders.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: November 1, 2011
    Assignee: Academia Sinica
    Inventors: Lie-fen Shyur, Chia-Chung Hou, Jyh-Horng Wu, Yi-Ping Chen, Sheng-Yang Wang, Chi-Chang Huang, Ning-Sun Yang
  • Patent number: 7972645
    Abstract: An extract from a tuber of a Dioscorea plant is disclosed. Also disclosed is a composition containing an extract from a tuber of a Dioscorea plant, as well as methods of using the extract and composition.
    Type: Grant
    Filed: September 2, 2008
    Date of Patent: July 5, 2011
    Assignee: Academia Sinica
    Inventors: Ning-Sun Yang, Jeng-Hwan Wang, Wen-Chi Wei
  • Publication number: 20100317603
    Abstract: Disclosed are extracts, compositions, and methods for treating cancer and inflammatory disorders. Also disclosed are methods for preparing extracts or compounds for treating the disorders.
    Type: Application
    Filed: June 16, 2009
    Publication date: December 16, 2010
    Applicant: Academia Sinica
    Inventors: Lie-Fen Shyur, Chia-Chung Hou, Jyh-Horng Wu, Yi-Ping Chen, Sheng-Yang Wang, Chi-Chang Huang, Ning-Sun Yang
  • Patent number: 7547455
    Abstract: Disclosed are extracts, compositions, and methods for treating cancer and inflammatory disorders. Also disclosed are methods for preparing extracts or compounds for treating the disorders.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: June 16, 2009
    Assignee: Academia Sinica
    Inventors: Lie-Fen Shyur, Chia-Chung Hou, Jyh-Horng Wu, Yi-Ping Chen, Sheng-Yang Wang, Chi-Chang Huang, Ning-Sun Yang
  • Patent number: 7527958
    Abstract: A truncated 1,3-1,4-?-D-glucanase. Also disclosed are related nucleic acid, vector, host cell, and preparation method.
    Type: Grant
    Filed: February 6, 2004
    Date of Patent: May 5, 2009
    Assignee: Academia Sinica
    Inventors: Lie-Fen Shyur, Tuan-Nan Wen, Shu-Hua Lee, Ning-Sun Yang
  • Publication number: 20090041803
    Abstract: An extract from a tuber of a Dioscorea plant is disclosed. Also disclosed is a composition containing an extract from a tuber of a Dioscorea plant, as well as methods of using the extract and composition.
    Type: Application
    Filed: September 2, 2008
    Publication date: February 12, 2009
    Applicant: Academia Sinica
    Inventors: Ning-Sun Yang, Jeng-Hwan Wang, Wen-Chi Wei
  • Patent number: 7419690
    Abstract: A method for enhancing proliferation of bone marrow cells or spleen cells with an alcohol-insoluble extract of a Dioscorea plant tuber obtained by stepwise treatment of an aqueous extract of Dioscorea plant tuber with aqueous-alcohol solvents.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: September 2, 2008
    Assignee: Academia Sinica
    Inventors: Ning-Sun Yang, Pei-Fen Su, Chin-Jin Li, Lie-Fen Shyur
  • Publication number: 20080152737
    Abstract: Disclosed are extracts, compositions, and methods for treating cancer and inflammatory disorders. Also disclosed are methods for preparing extracts or compounds for treating the disorders.
    Type: Application
    Filed: September 20, 2007
    Publication date: June 26, 2008
    Applicant: Academia Sinica
    Inventors: Lie-Fen Shyur, Chia-Chung Hou, Jyh-Horng Wu, Yi-Ping Chen, Sheng-Yang Wang, Chi-Chang Huang, Ning-Sun Yang
  • Publication number: 20080063664
    Abstract: The present invention provides a method utilizing mammalian expression system for generating virus-like particles (VLPs) of mammalian-hosted viruses, particularly SARS-CoV. The method of the present invention involves expression of viral structural proteins in Vero cells and thereby obtaining recombinant VLPs in the culture medium. SARS-VLPs generated by the method of the present invention are highly immunogenic and can elicit not only humoral but also cellular immune responses in a mammal.
    Type: Application
    Filed: September 5, 2006
    Publication date: March 13, 2008
    Inventors: Pei-Wen Hsiao, Ning-Sun Yang, Chang-Jen Huang, En-Hau Lin
  • Publication number: 20060105070
    Abstract: An extract from a tuber of a Dioscorea plant. Also disclosed is a composition containing an extract from a tuber of a Dioscorea plant and a cytokine, as well as methods of enhancing proliferation of bone marrow or spleen cells and stimulating regeneration of a specific lineage of hematopoietic cells.
    Type: Application
    Filed: January 12, 2006
    Publication date: May 18, 2006
    Inventors: Ning-Sun Yang, Fei-Fen Su, Chin-Jin Li, Lie-Fen Shyur
  • Patent number: 7037696
    Abstract: A truncated glucanase with an improved thermal stability and a higher specific enzymatic activity than the wild-type enzyme. The truncated glucanase is obtained by removing a number of amino acid residues from the C-terminal of the wild-type 1,3-1,4-?-D-glucanase of Fibrobacter succinogenes. The removal of the C-terminal amino acid residues can be conducted at the genetic level by modifying the gene encoding for the wild type enzyme using, for example, a PCR-based method. Or, it can also be conducted at the protein level by first producing the wild-type enzyme protein and then subjecting the wild-type protein to certain protease action to remove a portion of its C-terminal.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: May 2, 2006
    Assignee: Academia Sinica
    Inventors: Lie-Fen Shyur, Jui-Lin Chen, Ning-Sun Yang
  • Patent number: 7033617
    Abstract: The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of plant components of the Anoectochilus family. These active extracts and fractions are useful for preventing or inhibiting tumor growth.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: April 25, 2006
    Assignee: Academia Sinica
    Inventors: Lie-Fen Shyur, Ning-Sun Yang, Pei-Ling Kang, Show-Jane Sun, Sheng-Yang Wang
  • Publication number: 20050216959
    Abstract: A method is disclosed for the convenient transformation of the somatic cells of animals. Somatic cell transformation is useful for medical and veterinary care of genetic diseases, and other therapeutic or animal improvement purposes. The method makes use of an electric discharge particle acceleration apparatus which can inject very small particles of gold or other dense material carrying genetic constructs coated on them into the living cells of animals. The animals not only live, but there is no visible bruising or bleeding at the site of the treatment. The method is particularly adaptable since the force of the particle injection in such a spark discharge apparatus is adjustable by adjustments to the voltage of the spark discharge.
    Type: Application
    Filed: March 23, 2005
    Publication date: September 29, 2005
    Inventors: Winston Brill, Dennis McCabe, Ning-Sun Yang
  • Publication number: 20050118292
    Abstract: An extract from a tuber of a Dioscorea plant. Also disclosed is a composition containing an extract from a tuber of a Dioscorea plant and a cytokine, as well as methods of enhancing proliferation of bone marrow or spleen cells and stimulating regeneration of a specific lineage of hematopoietic cells.
    Type: Application
    Filed: December 1, 2003
    Publication date: June 2, 2005
    Inventors: Ning-Sun Yang, Pei-Fen Su, Chin-Jin Li, Lie-Fen Shyur
  • Publication number: 20050028234
    Abstract: A transformed plant cell or transgenic plant containing a recombinant nucleic acid that encodes a heterologous C-repeat/dehydration-responsive element-binding factor (CBF). Expression of the CBF factor increases tolerance of the cell or the plant to chilling, oxidative stress, water-deficit, or salt. Also disclosed are methods of producing such a transformed plant cell or transgenic plant.
    Type: Application
    Filed: July 30, 2003
    Publication date: February 3, 2005
    Inventors: Ming-Tsair Chan, Yee-Yung Charng, Ning-Sun Yang, Than-Hua Ho
  • Publication number: 20050009164
    Abstract: A truncated 1,3-1,4-?-D-glucanase. Also disclosed are related nucleic acid, vector, host cell, and preparation method.
    Type: Application
    Filed: February 6, 2004
    Publication date: January 13, 2005
    Inventors: Lie-Fen Shyur, Tuan-Nan Wen, Shu-Hua Lee, Ning-Sun Yang