Abstract: An ophthalmic device including: a body having: a posterior surface; an anterior surface; wherein a size of the body, a shape of the posterior surface, and a shape of the anterior surface configures the device to reside on a bulbar conjunctiva of an eye.

Abstract: A folded expandable gastro-retentive device and its uses in human medical care include, inter alia, appetite suppression in a subject in need thereof. The expanded device can be included in kits.

Abstract: A contact lens having more than one configuration is disclosed herein. The optical power of the contact lens may be dynamically changed through the different configurations of the contact lens. The different configurations may be actuated using a valve. Also disclosed herein is a contact lens comprising a dimension, which contact lens is configured to have the dimension change non-linearly as a function of a pressure applied to the contact lens.

Abstract: Gastric retentive devices and systems including a gastric retentive element including at least one expandable compartment and a dosage form element including at least one active agent are provided. The devices and systems, as well as kits thereof are used in a method for in-situ release and delivery of the at least one active agent.

Abstract: Dynamic contact lenses having an optical portion that has at least two quasi-stable configurations. Interaction of the dynamic contact lens with an eyelid and/or the tear meniscus can induce a transition between the quasi-stable configurations are disclosed. A dynamic contact lens can include one or more mechanisms that can facilitate interaction of the contact lens with an eyelid and/or a source of tear fluid such as a tear meniscus and that can facilitate transitioning between the quasi-stable configurations. The mechanisms can be configured to control the flow of tear fluid into and out of a tear volume formed between the posterior surface of the optical portion and the anterior surface of the cornea. The dynamic contact lenses can be used for correcting vision such as for correcting presbyopia, delaying the progression of myopia, or for correcting vision caused by an irregularly-shaped cornea.

Abstract: This invention relates to an expanded device and its uses in human medical care, which include, inter alia, appetite suppression in a subject in need thereof and kits comprising thereof.

Abstract: A folded expandable gastro-retentive device and its uses in human medical care include, inter alia, appetite suppression in a subject in need thereof. The expanded device can be included in kits.

Abstract: Gastric retentive devices and systems including a gastric retentive element including at least one expandable compartment and a dosage form element including at least one active agent are provided. The devices and systems, as well as kits thereof are used in a method for in-situ release and delivery of the at least one active agent.

Abstract: This invention relates to an expanded device and its uses in human medical care, which include, inter alia, appetite suppression in a subject in need thereof and kits comprising thereof.

Abstract: An accommodating intraocular lens (AIOL) assembly (10) including an optics assembly (12) including an inflatable member (14), and characterized by an extra-capsular-bag interface structure (16) for interfacing with ocular structure of an eye external to a capsular bag for implanting the AIOL (10) outside the capsular bag, the extra-capsular-bag interface structure (16) including a less-rigid portion (18) and a more-rigid portion (20) that define a volume therebetween which is at least partially filled with a fluid (22) and which is in fluid communication with the inflatable member (14) via at least one conduit (24), and wherein the less-rigid portion (18) is responsive to movement of the ocular structure to apply a pumping force on the fluid (22) to cause the fluid (22) to flow via the at least one conduit (24) to the inflatable member (14) so as to change the optical power of the optics assembly (12).

Abstract: An accommodating intraocular lens (AIOL) assembly (10) including an optics assembly (12) including an inflatable member (14), and characterised by an extra-capsular-bag interface structure (16) for interfacing with ocular structure of an eye external to a capsular bag for implanting the AIOL (10) outside the capsular bag, the extra-capsular-bag interface structure (16) including a less-rigid portion (18) and a more-rigid portion (20) that define a volume therebetween which is at least partially filled with a fluid (22) and which is in fluid communication with the inflatable member (14) via at least one conduit (24), and wherein the less-rigid portion (18) is responsive to movement of the ocular structure to apply a pumping force on the fluid (22) to cause the fluid (22) to flow via the at least one conduit (24) to the inflatable member (14) so as to change the optical power of the optics assembly (12).

Abstract: An accommodating intraocular lens (AIOL) (10) characterised by a first member (1) and a second member (3) arranged to correspond to anterior and posterior portions of a capsular bag, having an anterior-posterior axis passing centrally through the first and second members (1, 3), the first and second members (1, 3) being connected by one or more link members (2), a lens structure (4) including an inflatable lens (21), and a reservoir (23) of filling fluid (12) in fluid communication with the inflatable lens (21) through one or more channels (22), wherein axial movement of one of the first and second members (1, 3) along the anterior-posterior axis applies a pumping force to cause the filling fluid (12) to flow between the reservoir (23) and the inflatable lens (21).

Abstract: An intraocular optic assembly including an anterior haptic member and a posterior haptic member arranged to correspond to anterior and posterior portions of a capsular bag, respectively, having an anterior-posterior axis passing centrally through the anterior and posterior haptic members, bendable link members attached to and between the anterior and posterior haptic members, an optic, and a lever pivotally connected at on end thereof to a first attachment point on a periphery of the optic and connected at an opposite end thereof to a second attachment point on one of the bendable link members, wherein linear movement of one of the anterior and posterior haptic members along the anterior-posterior axis applies a lever force on the optic with the lever that causes the optic to move linearly along the anterior-posterior axis.

Abstract: An accommodating intraocular lens (AIOL) implant includes at least an anterior floating lens complex and a posterior lens complex, each of which comprises one or more optical elements, and a frame comprising one or more levers, which are coupled to the frame and the anterior floating lens complex. The levers are configured to leverage motion of the frame to move the anterior floating lens complex with respect to the posterior lens complex. Other embodiments are also described.

Abstract: Apparatus (20) is provided for applying current to a nerve (30). A cathode (40) is adapted to be placed in a vicinity of a cathodic longitudinal site of the nerve (30) and to apply a cathodic current to the nerve (30). A primary inhibiting anode (42) is adapted to be placed in a vicinity of a primary anodal longitudinal site of the nerve (30) and to apply a primary anodal current to the nerve (30). A secondary inhibiting anode (44) is adapted to be placed in a vicinity of a secondary anodal longitudinal site of the nerve (30) and to apply a secondary anodal current to the nerve (30), the secondary anodal longitudinal site being closer to the primary anodal longitudinal site than to the cathodic longitudinal site.