Patents by Inventor Nir I. Nativ
Nir I. Nativ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230190439Abstract: A sealant delivery device includes a housing, a matrix container connected with a distal end of the housing and being moveable between closed and opened positions, and a matrix, such as a hemostatic substrate, disposed within the matrix container. The sealant delivery device includes a sealant dispensing system in fluid communication with the matrix container that is configured for dispensing a sealant onto the matrix disposed within the matrix container. An actuator is coupled with the sealant dispensing system and the matrix container. The actuator is engageable for opening the matrix container for exposing the matrix and expressing the sealant onto the matrix. A component of the matrix container may be used to press the matrix and sealant expressed onto the matrix against target tissue to control bleeding of the target tissue.Type: ApplicationFiled: December 21, 2021Publication date: June 22, 2023Inventors: Nir I. Nativ, Jared Schneider, Geoffrey Navarro, Brian Aitken
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Patent number: 11020121Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage. The present invention further relates to circular stapling instruments and elongated tubular hollow sleeves deployed from such stapling instruments and establishing an enclosure around the stapled and resected tissues at the anastomotic joint.Type: GrantFiled: July 12, 2019Date of Patent: June 1, 2021Assignee: Cilag GmbH InternationalInventors: Nir I. Nativ, Silvia Chen
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Patent number: 11006937Abstract: The present invention is directed to a device for delivering a sealant to a tissue, comprising a sealant compartment, a cooling gas compartment, and a heater, all disposed inside a unified housing; with heater configured for rendering the sealant liquid or semi-liquid or molten and flowable; with sealant compartment configured for expressing the sealant in a flowable form from device via an exit nozzle; with gas compartment configured for expressing a cooling gas via a gas expression port; with exit nozzle and gas expression port co-directed into the same direction.Type: GrantFiled: January 30, 2019Date of Patent: May 18, 2021Assignee: Ethicon, Inc.Inventors: Nir I. Nativ, Thomas C. Weindl, Leo B. Kriksunov
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Patent number: 10993759Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site. The present invention further relates to hypothermic linear stapling instruments configured to pre-cool the tissues being joined by staples.Type: GrantFiled: October 20, 2017Date of Patent: May 4, 2021Assignee: Ethicon, Inc.Inventors: Nir I. Nativ, Leo B. Kriksunov, Robert J. Tannhauser, Silvia Chen
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Patent number: 10980913Abstract: The present invention is directed to tissue sealant compositions comprising: a multi-arm reactive polyethylene glycol polymer having at least 3 electrophilic groups; albumin; a buffer; water; and entrained gas as bubbles; wherein concentration of albumin in a liquid component of the sealant is within range of 50-200 mg/ml; and wherein concentration of multi-arm PEG in said liquid component of the sealant is within range of 25-100 mg/mL.Type: GrantFiled: March 5, 2018Date of Patent: April 20, 2021Assignee: Ethicon LLCInventors: Sridevi N. Dhanaraj, Nir I. Nativ, Ashley DeAnglis
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Patent number: 10918388Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage.Type: GrantFiled: August 23, 2018Date of Patent: February 16, 2021Assignee: Ethicon, Inc.Inventors: Nir I. Nativ, Yufu Li, Michael Logue, Glenn Cook, Gwan-Ywan Lai
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Patent number: 10888320Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections to improve tissue viability under hypoxia conditions, prevent tissue inflammation, and to prevent leakage. The present invention further relates to hypothermic circular stapling instruments configured to pre-cool the tissues being joined by staples.Type: GrantFiled: October 20, 2017Date of Patent: January 12, 2021Assignee: Ethicon, Inc.Inventors: Nir I. Nativ, Leo B. Kriksunov, Robert J. Tannhauser, Silvia Chen
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Publication number: 20200237356Abstract: The present invention is directed to a device for delivering a sealant to a tissue, comprising a sealant compartment, a cooling gas compartment, and a heater, all disposed inside a unified housing; with heater configured for rendering the sealant liquid or semi-liquid or molten and flowable; with sealant compartment configured for expressing the sealant in a flowable form from device via an exit nozzle; with gas compartment configured for expressing a cooling gas via a gas expression port; with exit nozzle and gas expression port co-directed into the same direction.Type: ApplicationFiled: January 30, 2019Publication date: July 30, 2020Inventors: Nir I. Nativ, Thomas C. Weindl, Leo B. Kriksunov
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Patent number: 10495631Abstract: The present invention relates to a system and methods for identifying a compound for de-fatting and functional recovery of macrosteatotic hepatocytes.Type: GrantFiled: July 17, 2017Date of Patent: December 3, 2019Assignee: Rutgers, The State University of New JerseyInventors: Martin L. Yarmush, Nir I. Nativ, Francois Berthiaume, Gabriel A. Yarmush, Tim Maguire, Rene S. Schloss
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Patent number: 10492791Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage. The present invention further relates to circular stapling instruments and elongated tubular hollow sleeves deployed from such stapling instruments and establishing an isolated enclosure around the stapled and resected tissues at the anastomotic joint.Type: GrantFiled: September 27, 2016Date of Patent: December 3, 2019Assignee: Ethicon LLCInventors: Nir I. Nativ, Silvia Chen, John P. Matonick, Leo B. Kriksunov, Robert J. Tannhauser
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Publication number: 20190328396Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage. The present invention further relates to circular stapling instruments and elongated tubular hollow sleeves deployed from such stapling instruments and establishing an enclosure around the stapled and resected tissues at the anastomotic joint.Type: ApplicationFiled: July 12, 2019Publication date: October 31, 2019Inventors: Nir I. Nativ, Silvia Chen
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Publication number: 20190269818Abstract: The present invention is directed to tissue sealant compositions comprising: a multi-arm reactive polyethylene glycol polymer having at least 3 electrophilic groups; albumin; a buffer; water; and entrained gas as bubbles; wherein concentration of albumin in a liquid component of the sealant is within range of 50-200 mg/ml; and wherein concentration of multi-arm PEG in said liquid component of the sealant is within range of 25-100 mg/mL.Type: ApplicationFiled: March 5, 2018Publication date: September 5, 2019Inventors: Sridevi N. Dhanaraj, Nir I. Nativ, Ashley DeAnglis
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Publication number: 20190269819Abstract: The present invention is directed to tissue sealant compositions comprising: a multi-arm reactive polyethylene glycol polymer having at least 3 electrophilic groups; albumin; a buffer; water; and entrained gas as bubbles; wherein concentration of albumin in a liquid component of the sealant is within range of 50-200 mg/ml; and wherein concentration of multi-arm PEG in said liquid component of the sealant is within range of 25-100 mg/mL and wherein PEG-SG portion is composed of a blend of 2 PEG-SG different in arm number or arm lengths.Type: ApplicationFiled: March 5, 2018Publication date: September 5, 2019Inventors: Sridevi N. Dhanaraj, Nir I. Nativ, Ashley DeAnglis
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Patent number: 10390834Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage. The present invention further relates to circular stapling instruments and elongated tubular hollow sleeves deployed from such stapling instruments and establishing an enclosure around the stapled and resected tissues at the anastomotic joint.Type: GrantFiled: September 27, 2016Date of Patent: August 27, 2019Assignee: Ethicon LLCInventors: Nir I. Nativ, Silvia Chen
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Patent number: 10278703Abstract: The present invention relates to circular anastomosis stapler and kits comprising reinforcing buttress materials and fixation tools that are slidably installed on the anvil shaft of such staplers which provides a temporary mechanical fixation of a reinforcing buttress to the anvil surface of a circular stapler during the insertion of the anvil into the tubular tissue. When the anvil, loaded with the buttress, is in the desired location, the fixation tool is pulled back along the anvil shaft and removed. The shaft is then connected to the stapling head and the stapling is performed. The present invention also relates to methods for using the kits and devices therein.Type: GrantFiled: March 21, 2016Date of Patent: May 7, 2019Assignee: Ethicon, Inc.Inventors: Nir I. Nativ, Yufu Li, John Matonick, Glenn Cook, Michael Logue
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Publication number: 20190117287Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site. The present invention further relates to hypothermic linear stapling instruments configured to pre-cool the tissues being joined by staples.Type: ApplicationFiled: October 20, 2017Publication date: April 25, 2019Inventors: Nir I. Nativ, Leo B. Kriksunov, Robert J. Tannhauser
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Publication number: 20190117220Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections to improve tissue viability under hypoxia conditions, prevent tissue inflammation, and to prevent leakage. The present invention further relates to hypothermic circular stapling instruments configured to pre-cool the tissues being joined by staples.Type: ApplicationFiled: October 20, 2017Publication date: April 25, 2019Inventors: Nir I. Nativ, Leo B. Kriksunov, Robert J. Tannhauser
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Patent number: 10265091Abstract: The present invention is directed to surgical staplers stapling and resecting tissue comprising a surgical buttress at least partially disposed on a tissue facing surface of at least one of the cartridge or the anvil, said buttress having width substantially larger than width of said tissue facing surfaces; said buttress comprising a first portion positioned over the deployable staples or over the staple forming pockets, and at least one flap portion not positioned over the deployable staples or over the staple forming pockets; said flap portion folded or rolled on itself and configured to be unfurlable and wrappable about the resected tissue. The present invention is also directed to methods of use of such stapler assembly devices.Type: GrantFiled: May 6, 2016Date of Patent: April 23, 2019Assignee: Ethicon LLCInventors: Nir I. Nativ, Sridevi Dhanaraj, Leo B. Kriksunov, Charles J. Scheib
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Patent number: 10258337Abstract: An apparatus includes a body assembly, a shaft, an end effector, and a cartridge. The end effector includes a jaw, a pivotable anvil, and a knife member. The cartridge includes a deck, a buttress assembly, and a folding sled. A first portion of the buttress assembly is positioned on top of the deck. A second portion of the buttress assembly is positioned within the longitudinal channel. The folding sled is configured to translate within the longitudinal channel to move the second portion of the buttress assembly to a position that is above the deck in response to actuation of the knife member. The second portion of the buttress assembly is thereby secured against edges of tissue severed by the knife member.Type: GrantFiled: April 20, 2016Date of Patent: April 16, 2019Assignee: Ethicon LLCInventors: Charles J. Scheib, Mark S. Zeiner, Nir I. Nativ, Sridevi Dhanaraj
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Publication number: 20190008519Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage.Type: ApplicationFiled: August 23, 2018Publication date: January 10, 2019Inventors: Nir I. Nativ, Yufu Li, Michael Logue, Glenn Cook, Gwan-Ywan Lai