Abstract: Systems and methods for fixing schedule of tasks using a remote optimization engine are provided. In one implementation, the system may periodically receive from a local server a data associated with a native scheduling engine. The system may process in a stateless manner the data periodically received from the local server using the optimization engine to update a prediction model. The system may also be configured to transmit information associated with the updated prediction model to the local server for enabling improvement of the native scheduling engine.

Abstract: Systems and methods for fixing schedule of tasks using a remote optimization engine are provided. In one implementation, the system may periodically receive from a local server a data associated with a native scheduling engine. The system may process in a stateless manner the data periodically received from the local server using the optimization engine to update a prediction model. The system may also be configured to transmit information associated with the updated prediction model to the local server for enabling improvement of the native scheduling engine.

Abstract: Systems and methods for fixing schedule of tasks using a remote optimization engine are provided. In one implementation, the system may periodically receive from a local server a data associated with a native scheduling engine. The system may process in a stateless manner the data periodically received from the local server using the optimization engine to update a prediction model. The system may also be configured to transmit information associated with the updated prediction model to the local server for enabling improvement of the native scheduling engine.

Abstract: Methods and systems for scheduling tasks for a two-route process for appointment booking include: receiving a request to book a new appointment for a service; outputting a first booking response for the request, wherein the first booking response is determined using a multi-route model, wherein the multi-route model is configured to determine booking responses in multiple different ways; and verifying the first booking response based on a second booking response determined using the multi-route model.

Abstract: The invention, in some embodiments, relates to compounds and methods for the prevention of ischemia reperfusion injury (IRI) in organs, and in particular to IRI in organs aged 35 years and older. Specific uses include prevention of IRI in native organs in vivo, in reimplantations and in transplantations of donor organs aged 35 years and older. Additional embodiments include the prophylaxis of delayed graft function (DGF) and reduction in the frequency, amount and duration of dialysis in recipients of deceased donor kidney transplantations. The methods entail contacting the organ in vivo or ex vivo with a temporary p53 inhibitor. Novel temporary dsNA p53 inhibitors are further provided.

Abstract: The invention, in some embodiments, relates to compounds and methods for the prevention of ischemia reperfusion injury (IRI) in organs, and in particular to IRI in organs aged 35 years and older. Specific uses include prevention of IRI in native organs in vivo, in reimplantations and in transplantations of donor organs aged 35 years and older. Additional embodiments include the prophylaxis of delayed graft function (DGF) and reduction in the frequency, amount and duration of dialysis in recipients of deceased donor kidney transplantations. The methods entail contacting the organ in vivo or ex vivo with a temporary p53 inhibitor. Novel temporary dsNA p53 inhibitors are further provided.

Abstract: The invention, in some embodiments, relates to compounds and methods for the prevention of ischemia reperfusion injury (IRI) in organs, and in particular to IRI in organs aged 35 years and older. Specific uses include prevention of IRI in native organs in vivo, in reimplantations and in transplantations of donor organs aged 35 years and older. Additional embodiments include the prophylaxis of delayed graft function (DGF) and reduction in the frequency, amount and duration of dialysis in recipients of deceased donor kidney transplantations. The methods entail contacting the organ in vivo or ex vivo with a temporary p53 inhibitor. Novel temporary dsNA p53 inhibitors are further provided.

Abstract: The invention, in some embodiments, relates to compounds and methods for the prevention of ischemia reperfusion injury (IRI) in organs, and in particular to IRI in organs aged 35 years and older. Specific uses include prevention of IRI in native organs in vivo, in reimplantations and in transplantations of donor organs aged 35 years and older. Additional embodiments include the prophylaxis of delayed graft function (DGF) and reduction in the frequency, amount and duration of dialysis in recipients of deceased donor kidney transplantations. The methods entail contacting the organ in vivo or ex vivo with a temporary p53 inhibitor. Novel temporary dsNA p53 inhibitors are further provided.

Abstract: A hair styling device including a first handle and a second handle; a first plate extending from said first handle and having a first heating element within said first plate, a second plate extending from said second handle and having a second heating element within said second plate, a hinge connecting said first handle and second handle, wherein said first and second plates are adapted to pivot relative to said first and second handles about an axis generally perpendicular to a longitudinal axis of said first and second handles, and wherein said first and second plates comprise a diamond dust protective layer between the heating elements and the respective plates.