Abstract: A system includes a first cavity with an open upper proximal end and a distal end including a plurality of ports. A second cavity can be concentric with and advanceable through the open upper proximal end of the first cavity. The second cavity can include an open upper proximal end. A plunger can be on a distal end of the second cavity. The plunger can be configured to move a first constituent from the first cavity through at least one of the plurality of ports. A plunger rod can be advanceable through the open upper proximal end of the second cavity and configured to move a second constituent from the first cavity through at least one of the plurality of ports.

Abstract: The system can include a multi-lumen chamber can removably connected to and in fluid communication with a proximal end of a mixing lumen and include a first lumen aligned with a second lumen. The first lumen can be configured to include a first constituent in a first cavity. A first plunger can be internally positioned within the first lumen to control flow of the first constituent from the first cavity into the mixing lumen. The first cavity can terminate in a first port in fluid communication with the proximal end of the mixing lumen. The second lumen can be configured to include a second constituent. A second plunger can be internally positioned within the second lumen. The second lumen can terminate in a second port adjacent the first port and in fluid communication with the proximal end of the mixing lumen.

Abstract: A system is disclosed for producing a mixture to deliver to a treatment site. The system can include a mixing lumen attachable to a proximal end of a delivery system. A multi-lumen chamber can be connected to a proximal end of the mixing lumen and include a first lumen aligned and adjacent a second lumen. The first lumen can receive a first constituent in a first state. The first lumen can include a first plunger to move the first constituent from the first lumen to the mixing lumen. The second lumen can include a second constituent and a second plunger to distally move the second constituent and the first constituent in a second state. Distally moving the second plunger causes the first constituent and the second constituent to be mixed together within the mixing lumen to form the mixture.

Abstract: A system is disclosed for producing a mixture to deliver to a treatment site. The system can include a connector with a connector vent so that air in the connector is expellable therethrough. A multi-lumen chamber can be connected to a proximal end of the connector and include a first lumen aligned and adjacent a second lumen. The first lumen can be configured to include a first constituent in a proximal portion of the first lumen, a second constituent in a distal portion of the first lumen, and a first plunger internally positioned within the first lumen to distally move the first constituent into the distal portion to mix with the second constituent in a first state to form a first mixture. The second lumen is configured to include a third constituent and a second plunger rod internally positioned within the second to distally move the third constituent.

Abstract: A system for producing a mixture to deliver to a treatment site. A multi-lumen chamber can be connected to a proximal end of a mixing lumen and include a first lumen aligned and adjacent a second lumen. The first lumen can be configured to include a first constituent in a proximal portion of the first lumen and a second constituent in a distal portion of the first lumen. A first plunger can be internally positioned within the first lumen to distally move the first constituent into the distal portion to mix with the second constituent in a first state to form a first mixture. The first lumen can terminate in a first port. The second lumen is configured to include a third constituent. A second plunger is internally positioned within the second lumen to distally move the third constituent and the first mixture.

Abstract: A system includes a connector with a central lumen. A multi-lumen chamber is removably connected to and in fluid communication with a proximal end of the central lumen. The multi-lumen chamber includes a first lumen aligned and adjacent a second lumen. The first lumen includes a first fluid in a proximal portion of the first lumen and a hydrophilic polymer in a distal portion of the first lumen, a first plunger rod within the first lumen to control flow of the first fluid into the distal portion to mix with the hydrophilic polymer in a first state to form a first mixture, and a first port. The second lumen includes a second fluid, a second plunger rod within the second lumen to distally move the second fluid and the first mixture in a second state, and a second port.

Abstract: A system is disclosed for producing a mixture to deliver to a treatment site. The system includes a mixing lumen attachable to a proximal end of a delivery system. A multi-lumen chamber can be removably connected to a proximal end of the mixing lumen and include a first lumen aligned with a second lumen. The first lumen can be configured to comprise a first constituent in a first state. The first lumen can include a first plunger to move the first constituent from the first lumen to the mixing lumen. The first lumen can terminate in a first port. The second lumen can be configured to include a second constituent. The second lumen can include a second plunger to distally move the second constituent and terminate in a second port. A vial adaptor can be included with a vial having a third constituent.

Abstract: A system is disclosed for producing a mixture to deliver to a treatment site. The system can include a first chamber with an inner cavity including a first constituent and an outer cavity concentric with the first cavity and including a second constituent. A partition can be openable and separate the first and second cavities. A second chamber can include a third constituent and be concentric with the first chamber. Moving the first chamber and/or the second chamber relative to the other can cause the partition to open so that the first constituent and the second constituent mix with each other to form a first mixture. Applying a force to the system can cause the first mixture and the third constituent to egress through distal portions of the first and second chambers and mix together to form the mixture for delivery to the treatment site.