Patents by Inventor Nithya Srinivasan
Nithya Srinivasan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230416367Abstract: The present disclosure provides a combination therapy which comprises: (i) an active agent that binds PD-1 (e.g., an anti-PD-1 antibody), (ii) an active agent that binds TIM-3 (e.g., an anti-TIM-3 antibody), and/or (iii) an active agent that binds LAG-3 (e.g., an anti-LAG-3 antibody). The present disclosure provides pharmaceutical compositions thereof, uses thereof, and methods of treatment which include administering the combination therapy to a subject, including methods of treating cancer.Type: ApplicationFiled: June 6, 2023Publication date: December 28, 2023Inventors: Paul E. Hoyle, Zhiwan Dong, Thomas Condamine, Nithya Srinivasan, John E. Janik, Kevin N. Heller
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Patent number: 10196459Abstract: The disclosure relates to molecular protein brushes and devices comprising regions of protein brushes.Type: GrantFiled: April 30, 2016Date of Patent: February 5, 2019Assignee: The Regents of the University of CaliforniaInventors: Sanjay Kumar, Nithya Srinivasan, Maniraj Bhagawati, Badriprasad Ananthanarayanan
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Publication number: 20160319041Abstract: The disclosure relates to molecular protein brushes and devices comprising regions of protein brushes.Type: ApplicationFiled: April 30, 2016Publication date: November 3, 2016Inventors: Sanjay Kumar, Nithya Srinivasan, Maniraj Bhagawati, Badriprasad Ananthanarayanan
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Patent number: 7541310Abstract: This invention relates to catalysts comprising a catalytic metal deposited on a composite support with well-dispersed chemical “anchor” species acting as nucleation centers for catalytic metal crystallites growth. The catalysts have the advantage that the average catalytic metal crystallite size can be controlled by the molar ratio of catalytic metal to chemical “anchor,” and is not limited by the porous structure of the support. A preferred embodiment comprises a cobalt-based catalyst on a silica-alumina support made by a co-gel method, wherein its average pore size can be controlled by the pH. The alumina species in the support most likely serve as chemical “anchors” to control the dispersion of cobalt species, such that the average cobalt crystallite size can be greater than the average pore size.Type: GrantFiled: October 12, 2004Date of Patent: June 2, 2009Assignee: ConocoPhillips CompanyInventors: Rafael L. Espinoza, Kandaswamy Jothimurugesan, Kevin L. Coy, James Dale Ortego, Jr., Nithya Srinivasan, Olga P. Ionkina
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Patent number: 7402612Abstract: This invention relates to methods for making a stabilized transition alumina of enhanced hydrothermal stability, which include the introduction of at least one structural stabilizer; a steaming step before or after the introduction step, wherein steaming is effective in transforming a transition alumina at least partially to boehmite and/or pseudoboehmite; and a calcining step to create a stabilized transition alumina. The combination of the structural stabilizer and the steaming step is believed to impart high hydrothermal stability to the alumina crystal lattice. Particularly preferred structural stabilizers include boron, cobalt, and zirconium. The stabilized transition alumina is useful as a catalyst support for high water partial pressure environments, and is particularly useful for making a catalyst having improved hydrothermal stability. The invention more specifically discloses Fischer-Tropsch catalysts and processes for the production of hydrocarbons from synthesis gas.Type: GrantFiled: October 16, 2003Date of Patent: July 22, 2008Assignee: ConocoPhillips CompanyInventors: Yaming Jin, Rafael L. Espinoza, Nithya Srinivasan, Olga P. Ionkina
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Patent number: 7056955Abstract: According to a preferred embodiment, the present invention features a bulk catalyst that includes precipitated cobalt metal. The precipitated cobalt catalyst further includes a textural promoter, a binder and optionally a Group I metal. The method of making the catalyst is optimized so as to enhance attrition resistance and improve activity. According to some embodiments, the present catalyst is made by a method that includes one or a combination of: calcination under optimized temperature conditions; exposure to an acidic solution; and addition of a binder to a suspension of a precipitate. According to some embodiments, a Fischer-Tropsch process includes contacting the present catalyst with a feed stream containing carbon monoxide and hydrogen so as to produce hydrocarbons.Type: GrantFiled: December 22, 2003Date of Patent: June 6, 2006Assignee: ConocoPhillips CompanyInventors: Rafael L. Espinoza, Kandaswamy Jothimurugesan, Ajoy P. Raje, Kevin L. Coy, Nithya Srinivasan
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Patent number: 7056857Abstract: A method for making a catalyst is provided that features loading a catalytic metal to a support using at least two different precursor compounds of that said metal; and loading the promoter to the support in an amount effective so as to achieve similar promotion as for a comparable catalyst comprising a greater amount of the promoter using only one precursor compound, where the catalytic metal is selected from among Group 8 metals, 9 metal, Group 10 metals, and combinations thereof. The promoter is preferably boron, silver, a noble metal, or combination thereof. Also provided are catalysts made by the method and Fischer-Tropsch processes that include contacting synthesis gas with a catalyst made by the method.Type: GrantFiled: October 14, 2004Date of Patent: June 6, 2006Assignee: ConocoPhillips CompanyInventors: Nithya Srinivasan, Rafael L. Espinoza, Kevin L. Coy, Kandaswamy Jothimurugesan
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Patent number: 7012104Abstract: A hydrothermally-stable catalyst, method for making the same, and process for producing hydrocarbon, wherein the catalyst is used in synthesis gas conversion to hydrocarbons. In one embodiment, the method comprises depositing a compound of a catalytic metal selected from Groups 8, 9, and 10 of the Periodic Table on a support material comprising boehmite to form a composite material; and calcining the composite material to form the catalyst. In other embodiments, the support material comprises synthetic boehmite, natural boehmite, pseudo-boehmite, or combinations thereof.Type: GrantFiled: October 16, 2003Date of Patent: March 14, 2006Assignee: ConocoPhillips CompanyInventors: Rafael L. Espinoza, Yaming Jin, Kandaswamy Jothimurugesan, Nithya Srinivasan
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Publication number: 20050119116Abstract: This invention relates to catalysts comprising a catalytic metal deposited on a composite support with well-dispersed chemical “anchor” species acting as nucleation centers for catalytic metal crystallites growth. The catalysts have the advantage that the average catalytic metal crystallite size can be controlled by the molar ratio of catalytic metal to chemical “anchor,” and is not limited by the porous structure of the support. A preferred embodiment comprises a cobalt-based catalyst on a silica-alumina support made by a co-gel method, wherein its average pore size can be controlled by the pH. The alumina species in the support most likely serve as chemical “anchors” to control the dispersion of cobalt species, such that the average cobalt crystallite size can be greater than the average pore size.Type: ApplicationFiled: October 12, 2004Publication date: June 2, 2005Applicant: ConocoPhillips CompanyInventors: Rafael Espinoza, Kandaswamy Jothimurugesan, Kevin Coy, James Ortego, Nithya Srinivasan, Olga Ionkina
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Publication number: 20050107249Abstract: A method for making a catalyst is provided that features loading a catalytic metal to a support using at least two different precursor compounds of that said metal; and loading the promoter to the support in an amount effective so as to achieve similar promotion as for a comparable catalyst comprising a greater amount of the promoter using only one precursor compound, where the catalytic metal is selected from among Group 8 metals, 9 metal, Group 10 metals, and combinations thereof. The promoter is preferably boron, silver, a noble metal, or combination thereof. Also provided are catalysts made by the method and Fischer-Tropsch processes that include contacting synthesis gas with a catalyst made by the method.Type: ApplicationFiled: October 14, 2004Publication date: May 19, 2005Applicant: ConocoPhillips CompanyInventors: Nithya Srinivasan, Rafael Espinoza, Kevin Coy, Kandaswamy Jothimurugesan
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Publication number: 20040259960Abstract: According to a preferred embodiment, the present invention features a bulk catalyst that includes precipitated cobalt metal. The precipitated cobalt catalyst further includes a textural promoter, a binder and optionally a Group I metal. The method of making the catalyst is optimized so as to enhance attrition resistance and improve activity. According to some embodiments, the present catalyst is made by a method that includes one or a combination of: calcination under optimized temperature conditions; exposure to an acidic solution; and addition of a binder to a suspension of a precipitate. According to some embodiments, a Fischer-Tropsch process includes contacting the present catalyst with a feed stream containing carbon monoxide and hydrogen so as to produce hydrocarbons.Type: ApplicationFiled: December 22, 2003Publication date: December 23, 2004Applicant: ConocoPhillips CompanyInventors: Rafael L. Espinoza, Kandaswamy Jothimurugesan, Ajoy P. Raje, Kevin L. Coy, Nithya Srinivasan
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Patent number: 6822008Abstract: A method for making a catalyst is provided that features loading a catalytic metal to a support using at least two different precursor compounds of that said metal; and loading the promoter to the support in an amount effective so as to achieve similar promotion as for a comparable catalyst comprising a greater amount of the promoter using only one precursor compound, where the catalytic metal is selected from among Group 8 metals, 9 metal, Group 10 metals, and combinations thereof. The promoter is preferably boron, silver, a noble metal, or combination thereof. Also provided are catalysts made by the method and Fischer-Tropsch processes that include contacting synthesis gas with a catalyst made by the method.Type: GrantFiled: September 6, 2002Date of Patent: November 23, 2004Assignee: ConocoPhillips CompanyInventors: Nithya Srinivasan, Rafael L. Espinoza, Kevin L. Coy, Kandaswamy Jothimurugesan
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Publication number: 20040132833Abstract: A hydrothermally-stable catalyst, method for making the same, and process for producing hydrocarbon, wherein the catalyst is used in synthesis gas conversion to hydrocarbons. In one embodiment, the method comprises depositing a compound of a catalytic metal selected from Groups 8, 9, and 10 of the Periodic Table on a support material comprising boehmite to form a composite material; and calcining the composite material to form the catalyst. In other embodiments, the support material comprises synthetic boehmite, natural boehmite, pseudo-boehmite, or combinations thereof.Type: ApplicationFiled: October 16, 2003Publication date: July 8, 2004Applicant: ConocoPhillips CompanyInventors: Rafael L. Espinoza, Yaming Jin, Kandaswamy Jothimurugesan, Nithya Srinivasan
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Publication number: 20040127586Abstract: This invention relates to methods for making a stabilized transition alumina of enhanced hydrothermal stability, which include the introduction of at least one structural stabilizer; a steaming step before or after the introduction step, wherein steaming is effective in transforming a transition alumina at least partially to boehmite and/or pseudoboehmite; and a calcining step to create a stabilized transition alumina. The combination of the structural stabilizer and the steaming step is believed to impart high hydrothermal stability to the alumina crystal lattice. Particularly preferred structural stabilizers include boron, cobalt, and zirconium. The stabilized transition alumina is useful as a catalyst support for high water partial pressure environments, and is particularly useful for making a catalyst having improved hydrothermal stability. The invention more specifically discloses Fischer-Tropsch catalysts and processes for the production of hydrocarbons from synthesis gas.Type: ApplicationFiled: October 16, 2003Publication date: July 1, 2004Applicant: ConocoPhillips CompanyInventors: Yaming Jin, Rafael L. Espinoza, Nithya Srinivasan, Olga P. Ionkina
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Publication number: 20040110852Abstract: A process is disclosed for producing hydrocarbons. The process involves contacting a feed stream comprising hydrogen and carbon monoxide with a catalyst in a reaction zone maintained at conversion-promoting conditions effective to produce an effluent stream comprising hydrocarbons. In accordance with this invention, the catalyst used in the process includes at least a Fischer-Tropsch metal selected from Groups 8, 9, and 10 of the periodic table and combinations thereof. The catalyst also includes a fluorided clay support material. The fluorided clay is preferably a fluorided bentonite.Type: ApplicationFiled: December 4, 2002Publication date: June 10, 2004Applicant: ConocoPhillips CompanyInventors: Nithya Srinivasan, Sergej A. Maslov, Norman Herron, Stephan Schwarz, Munirpallam A. Subramanian
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Publication number: 20040048937Abstract: A method for making a catalyst is provided that features loading a catalytic metal to a support using at least two different precursor compounds of that said metal; and loading the promoter to the support in an amount effective so as to achieve similar promotion as for a comparable catalyst comprising a greater amount of the promoter using only one precursor compound, where the catalytic metal is selected from among Group 8 metals, 9 metal, Group 10 metals, and combinations thereof. The promoter is preferably boron, silver, a noble metal, or combination thereof. Also provided are catalysts made by the method and Fischer-Tropsch processes that include contacting synthesis gas with a catalyst made by the method.Type: ApplicationFiled: September 6, 2002Publication date: March 11, 2004Applicant: Conoco Inc.Inventors: Nithya Srinivasan, Rafael L. Espinoza, Kevin L. Coy, Kandaswamy Jothimurugesan
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Publication number: 20030119658Abstract: This invention provides a method for recovering rhenium oxide from a material containing rhenium by itself or rhenium in combination with some other element, such as an element catalytically active for a catalytic process, such as hydrogenation, oxidation, reforming, and hydrocracking. The method includes conversion of rhenium to a sublimable oxide via oxidation, heating in an oxidizing atmosphere to sublime the oxide as a volatized oxide, and then isolation of rhenium from the volatized oxide.Type: ApplicationFiled: December 18, 2002Publication date: June 26, 2003Applicant: ConocoPhillips CompanyInventors: Joe D. Allison, Nithya Srinivasan, Sriram Ramani
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Publication number: 20030105171Abstract: A process for producing hydrocarbons by the Fischer-Tropsch process is provided in which a cobalt-containing catalyst is supported on a modified zirconia support selected from among silica-zirconia, tungstated zirconia, and sulfated zirconia. The catalyst shows improved performance of up to 70% in the Fischer-Tropsch reaction as compared to a corresponding catalyst supported on unmodified zirconia.Type: ApplicationFiled: November 8, 2002Publication date: June 5, 2003Applicant: Conoco Inc.Inventors: Munirpallam A. Subramanian, Norman Herron, Stephan Schwarz, Sergej A. Maslov, Nithya Srinivasan
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Publication number: 20030105170Abstract: The present invention teaches a method for increasing the cobalt surface area per gram of catalyst in a cobalt Fischer-Tropsch catalyst, supported on a silica-based carrier material, by using cobalt amine carbonate precursors. A Fischer-Tropsch catalyst preferably includes a catalytically active first metal containing cobalt, and a carrier material containing silica or a silica compound with a cobalt surface area greater than 13 m2/g catalyst. The catalyst active in the FT reaction has a minimum alpha value of 0.87 and a CO conversion of 24 wt % or more. In accordance with another preferred embodiment, a process for producing a Fischer-Tropsch catalyst includes saturating silica or silica compounds with a solution of cobalt amine carbonate, removing the excess solution by filtration, heating the resulting product in order to allow cobalt hydroxycarbonate to precipitate, and drying and calcining the resulting product. Optionally the calcined product is reduced.Type: ApplicationFiled: September 23, 2002Publication date: June 5, 2003Applicant: Conoco Inc.Inventors: Kandaswamy Jothimurugesan, Rafael L. Espinoza, Nithya Srinivasan
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Publication number: 20030027874Abstract: A catalyst and process for producing hydrocarbons using the catalyst is provided. The process involves contacting a feed stream comprising hydrogen and carbon monoxide with the catalyst in a reaction zone maintained at conversion-promoting conditions effective to produce an effluent stream comprising hydrocarbons. In accordance with this invention the catalyst used in the process includes at least one catalytic metal for Fischer-Tropsch reactions, preferably cobalt. The catalyst further includes a structural component, preferably a support, that includes a metal selected from the group consisting of oxides of Group 2 metals, Group 3 metals, Group 6 metals, Group 8 metals, Group 12 metals, Group 15 metals, and combinations thereof, preferably as the oxide.Type: ApplicationFiled: June 27, 2002Publication date: February 6, 2003Applicant: Conoco Inc.Inventors: Norman Herron, Kostantinos Kourtakis, Munirpallam A. Subramanian, Olga Ionkina, Nithya Srinivasan