Abstract: A directional and scalable (DISC) electrode array includes an insulating body, a first plurality of microelectrodes, and a second plurality of microelectrodes. The insulating body includes an electrically insulating material, and has a length and a diameter. The diameter is at least 400 microns, and the length is greater than the diameter. The first plurality of microelectrodes is disposed along the length of the insulating body. The second plurality of microelectrodes is disposed along the length of the insulating body opposite the first plurality of microelectrodes. Further columns of microelectrodes improve the directional sensitivity of DISC.

Abstract: A method includes obtaining a first imaging scan and a second imaging scan of a single subject brain. The first imaging scan is converted to a first dataset, and the second imaging scan is converted to a second dataset. A sequence-adaptive multimodal segmentation algorithm is applied to the first dataset and the second dataset. The sequence-adaptive multimodal segmentation algorithm performs automatic intensity-based tissue classification to generate a first labelled dataset and a second labeled dataset. The first labeled dataset and the second labeled dataset are automatically co-registered to each other to generate a transformation matrix based on the first labeled dataset and the second labeled dataset. The transformation matrix is applied to align the first dataset and the second dataset.

Abstract: This invention relates generally to methods for localization and visualization of implanted electrodes and penetrating probes in the brain in 3D space with consideration of functional brain anatomy. Particularly, this invention relates to precise and sophisticated methods of localizing and visualizing implanted electrodes to the cortical surface and/or topological volumes of a patient's brain using 3D modeling, and more particularly to methods of accurately mapping implanted electrodes to the cortical topology and/or associated topological volumes of a patient's brain, such as, for example, by utilizing recursive grid partitioning on a manipulable virtual replicate of a patient's brain. This invention further relates to methods of surgical intervention utilizing accurate cortical surface modeling and/or topological volume modeling of a patient's brain for targeted placement of electrodes and/or utilization thereof for surgical intervention in the placement of catheters or other probes into it.

Abstract: A method includes obtaining a first imaging scan and a second imaging scan of a single subject brain. The first imaging scan is converted to a first dataset, and the second imaging scan is converted to a second dataset. A sequence-adaptive multimodal segmentation algorithm is applied to the first dataset and the second dataset. The sequence-adaptive multimodal segmentation algorithm performs automatic intensity-based tissue classification to generate a first labelled dataset and a second labeled dataset. The first labeled dataset and the second labeled dataset are automatically co-registered to each other to generate a transformation matrix based on the first labeled dataset and the second labeled dataset. The transformation matrix is applied to align the first dataset and the second dataset.

Abstract: This invention relates generally to systems and methods for multifocal direct brain stimulation to enhance cognitive processing, such as but not limited to stimulation-induced modulation of memory.

Abstract: This invention relates generally to methods for localization and visualization of implanted electrodes and penetrating probes in the brain in 3D space with consideration of functional brain anatomy. Particularly, this invention relates to precise and sophisticated methods of localizing and visualizing implanted electrodes to the cortical surface and/or topological volumes of a patient's brain using 3D modeling, and more particularly to methods of accurately mapping implanted electrodes to the cortical topology and/or associated topological volumes of a patient's brain, such as, for example, by utilizing recursive grid partitioning on a manipulable virtual replicate of a patient's brain. This invention further relates to methods of surgical intervention utilizing accurate cortical surface modeling and/or topological volume modeling of a patient's brain for targeted placement of electrodes and/or utilization thereof for surgical intervention in the placement of catheters or other probes into it.

Abstract: This invention relates generally to methods for localization and visualization of implanted electrodes and penetrating probes in the brain in 3D space with consideration of functional brain anatomy. Particularly, this invention relates to precise and sophisticated methods of localizing and visualizing implanted electrodes to the cortical surface and/or topological volumes of a patient's brain using 3D modeling, and more particularly to methods of accurately mapping implanted electrodes to the cortical topology and/or associated topological volumes of a patient's brain, such as, for example, by utilizing recursive grid partitioning on a manipulable virtual replicate of a patient's brain. This invention further relates to methods of surgical intervention utilizing accurate cortical surface modeling and/or topological volume modeling of a patient's brain for targeted placement of electrodes and/or utilization thereof for surgical intervention in the placement of catheters or other probes into it.

Abstract: This invention relates generally to systems and methods for multifocal direct brain stimulation to enhance cognitive processing, such as but not limited to stimulation-induced modulation of memory.

Abstract: The present invention relates to an improved process for the preparation of apixaban and intermediates thereof. In particular, the invention relates to an improved process for the preparation of an amorphous form of apixaban. The invention also relates to a pharmaceutical composition comprising an amorphous form of apixaban for oral administration as an antithrombotic agent.

Abstract: The present invention discloses an amorphous form of apixaban, process of preparation and compositions thereof.