Patents by Inventor Nizal Chandrakumar

Nizal Chandrakumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule apoptosis promoters
    Patent number: 8586542
    Abstract: The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: November 19, 2013
    Assignee: Joyant Pharmaceuticals, Inc.
    Inventors: Gunnar J. Hanson, David Thomas, Nizal Chandrakumar, Susan Harran
  • SMALL MOLECULE APOPTOSIS PROMOTERS
    Publication number: 20130281385
    Abstract: The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
    Type: Application
    Filed: June 28, 2012
    Publication date: October 24, 2013
    Inventors: Gunnar J. Hanson, Davis Thomas, Nizal Chandrakumar, Susan Harran
  • Small molecule apoptosis promoters
    Patent number: 8222291
    Abstract: The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
    Type: Grant
    Filed: October 4, 2010
    Date of Patent: July 17, 2012
    Assignee: Joyant Pharmaceuticals, Inc.
    Inventors: Gunnar J. Hanson, David Thomas, Nizal Chandrakumar, Susan Harran
  • Small molecule apoptosis promoters
    Publication number: 20120082640
    Abstract: The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
    Type: Application
    Filed: October 4, 2010
    Publication date: April 5, 2012
    Inventors: Gunnar J. Hanson, David Thomas, Nizal Chandrakumar, Susan Harran
  • Dimeric pyrrolidine amide-containing small molecule apoptosis promoters
    Patent number: 7807699
    Abstract: The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: October 5, 2010
    Assignee: Joyant Pharmaceuticals, Inc.
    Inventors: Gunnar J. Hanson, David Thomas, Nizal Chandrakumar, Susan Harran
  • Small molecule apoptosis promoters
    Publication number: 20080051389
    Abstract: The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
    Type: Application
    Filed: March 21, 2007
    Publication date: February 28, 2008
    Inventors: Gunnar Hanson, David Thomas, Nizal Chandrakumar, Susan Harran
  • Substituted azetidinones
    Publication number: 20070105832
    Abstract: Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd? are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.
    Type: Application
    Filed: April 4, 2006
    Publication date: May 10, 2007
    Inventors: Thomas Bannister, Cassandra Celatka, Nizal Chandrakumar, Hongfeng Deng, Zihong Guo, Lei Jin, Tsvetelina Lazarova, Jian Lin, Scott Moe, Pamela Nagafuji, Manuel Navia, Amy Ripka, Michael Rynkiewicz, Kerry Spear, James Stickler, Roger Xie
  • Meta-substituted phenylene sulphonamide derivatives
    Publication number: 20050176821
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the ?v?3 integrin.
    Type: Application
    Filed: September 8, 2003
    Publication date: August 11, 2005
    Applicant: G. D. Searle & Co.
    Inventors: Nizal Chandrakumar, Michael Clare, Wendell Doubleday, Alan Gasiecki, Mark Russell
  • Heteroarylalkanoic acids as integrin receptor antagonists derivatives
    Publication number: 20050043344
    Abstract: The present invention relates to pharmaceutical compositions comprising compounds of the Formula I, or a pharmaceutically acceptable salt thereof, and methods of selectively inhibiting or antagonizing the ?V?3 and/or the ?V?5 integrin without significantly inhibiting the ?V?6 integrin.
    Type: Application
    Filed: December 22, 2003
    Publication date: February 24, 2005
    Inventors: Mark Boys, Lori Schretzman, Michael Tollefson, Nizal Chandrakumar, Ish Khanna, Maria Nguyen, Victoria Downs, Scott Mohler, Glen Gesicki, Thomas Penning, Barbara Chen, Yaping Wang, Albert Khilevich, Bipinchandra Desai, Yi Yu, John Wendt, Heather Stenmark, Hongwei Wu, Renee Huff, Srinivasan Nagarajan, Balekudru Devadas, Hwang-Fun Lu, Mark Russell, Dale Spangler, Mihir Parikh
  • Meta-substituted phenylene sulphonamide derivatives
    Patent number: 6677308
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 integrin.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: January 13, 2004
    Assignee: G. D. Searle & Co.
    Inventors: Nizal Chandrakumar, Michael Clare, Wendell Doubleday, Alan F. Gasiecki, Mark A. Russell
  • Meta-substituted phenylene sulphonamide derivatives
    Patent number: 5843906
    Abstract: The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: December 1, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Nizal Chandrakumar, Michael Clare, Wendell Doubleday, Alan F. Gasiecki, Mark A. Russell
  • Meta-substituted phenylene derivatives
    Patent number: 5773646
    Abstract: The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: June 30, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Nizal Chandrakumar, Barbara B. Chen, Helen Y. Chen, Michael Clare, Alan F. Gasiecki, Richard A. Haack, James W. Malecha, Peter G. Ruminski, Mark A. Russell