Patents by Inventor Noah Helman
Noah Helman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240150774Abstract: The disclosure relates to recombinant host cells including strain modifications effective to improve titer, yield and/or productivity of fatty acid derivatives. The disclosure further relates to cell cultures including the recombinant host cells for the fermentative production of fatty acid derivatives and compositions thereof.Type: ApplicationFiled: June 29, 2023Publication date: May 9, 2024Inventors: Derek L. GREENFIELD, Andreas W. Schirmer, Elizabeth J. Clarke, Eli S. Groban, Bernardo M. Da Costa, Zhihao Hu, Kevin Holden, Noah Helman
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Publication number: 20220267813Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.Type: ApplicationFiled: April 29, 2022Publication date: August 25, 2022Inventors: Andreas W. SCHIRMER, Noah HELMAN, Haibo WANG, Zhihao HU, Vikranth ARLAGADDA, Alma Itzel RAMOS-SOLIS, Elizabeth CLARKE
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Patent number: 11359216Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.Type: GrantFiled: June 1, 2020Date of Patent: June 14, 2022Assignee: Genomatica, Inc.Inventors: Andreas W. Schirmer, Noah Helman, Haibo Wang, Zhihao Hu, Vikranth Arlagadda, Alma Itzel Ramos-Solis, Elizabeth Clarke
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Publication number: 20210348173Abstract: The disclosure relates to recombinant host cells including strain modifications effective to improve titer, yield and/or productivity of fatty acid derivatives. The disclosure further relates to cell cultures including the recombinant host cells for the fermentative production of fatty acid derivatives and compositions thereof.Type: ApplicationFiled: June 1, 2021Publication date: November 11, 2021Inventors: Derek L. GREENFIELD, Andreas W. SCHIRMER, Elizabeth J. CLARKE, Eli S. GROBAN, Bernardo M. DA COSTA, Zhihao HU, Kevin HOLDEN, Noah HELMAN
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Publication number: 20210309979Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.Type: ApplicationFiled: December 9, 2020Publication date: October 7, 2021Inventors: Andrew M. SHUMAKER, Bernardo M. DA COSTA, Kevin HOLDEN, Louis G. HOM, Tarah S. BARON, Noah HELMAN
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Patent number: 11060099Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.Type: GrantFiled: July 14, 2017Date of Patent: July 13, 2021Assignee: Genomatica, Inc.Inventors: Derek L. Greenfield, Andreas W. Schirmer, Elizabeth J. Clarke, Eli S. Groban, Bernardo M. Da Costa, Zhihao Hu, Kevin Holden, Noah Helman
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Publication number: 20210071207Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.Type: ApplicationFiled: June 1, 2020Publication date: March 11, 2021Applicant: Genomatica, Inc.Inventors: Andreas W. Schirmer, Noah HELMAN, Haibo Wang, Zhihao Hu, Vikranth Arlagadda, Alma Itzel RAMOS-SOLIS, Elizabeth Clarke
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Patent number: 10894953Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.Type: GrantFiled: January 18, 2018Date of Patent: January 19, 2021Assignee: Genomatica, Inc.Inventors: Andrew M. Shumaker, Bernardo M. da Costa, Kevin Holden, Louis G. Hom, Tarah S. Baron, Noah Helman
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Publication number: 20200277636Abstract: Provided herein are non-naturally occurring microbial organisms comprising a methane-oxidizing metabolic pathway. The invention additionally comprises non-naturally occurring microbial organisms comprising pathways for the production of chemicals. The invention additionally provides methods for using said organisms for the production of chemicals.Type: ApplicationFiled: March 12, 2020Publication date: September 3, 2020Inventors: Noah HELMAN, Elizabeth CLARKE, Derek GREENFIELD
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Patent number: 10689674Abstract: Provided herein are non-naturally occurring microbial organisms comprising a methane-oxidizing metabolic pathway. The invention additionally comprises non-naturally occurring microbial organisms comprising pathways for the production of chemicals. The invention additionally provides methods for using said organisms for the production of chemicals.Type: GrantFiled: April 14, 2015Date of Patent: June 23, 2020Assignee: INDUSTRIAL MICROBES, INC.Inventors: Noah Helman, Elizabeth Clarke, Derek Greenfield
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Patent number: 10676763Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.Type: GrantFiled: July 17, 2015Date of Patent: June 9, 2020Assignee: GENOMATICA, INC.Inventors: Andreas W. Schirmer, Noah Helman, Haibo Wang, Zhihao Hu, Vikranth Arlagadda, Alma Itzel Ramos-Solis, Elizabeth Clarke
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Publication number: 20180327728Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.Type: ApplicationFiled: January 18, 2018Publication date: November 15, 2018Inventors: Andrew M. SHUMAKER, Bernardo M. da Costa, Kevin HOLDEN, Louis G. HOM, Tarah S. BARON, Noah HELMAN
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Patent number: 9879239Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.Type: GrantFiled: March 15, 2013Date of Patent: January 30, 2018Assignee: REG LIFE SCIENCES, LLCInventors: Andrew M. Shumaker, Bernardo M. Da Costa, Kevin Holden, Louis G. Hom, Tarah S. Baron, Noah Helman
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Publication number: 20180010137Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.Type: ApplicationFiled: July 14, 2017Publication date: January 11, 2018Inventors: Derek L. GREENFIELD, Andreas W. Schirmer, Elizabeth J. CLARKE, Eli S. GROBAN, Bernardo M. Da Costa, Zhihao Hu, Kevin Holden, Noah Helman
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Publication number: 20170204436Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.Type: ApplicationFiled: July 17, 2015Publication date: July 20, 2017Inventors: Andreas W. Schirmer, Noah HELMAN, Haibo Wang, Zhihao Hu, Vikranth Arlagadda, Alma Itzel RAMOS-SOLIS, Elizabeth Clarke
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Publication number: 20170037438Abstract: Provided herein are non-naturally occurring microbial organisms comprising a methane-oxidizing metabolic pathway. The invention additionally comprises non-naturally occurring microbial organisms comprising pathways for the production of chemicals. The invention additionally provides methods for using said organisms for the production of chemicals.Type: ApplicationFiled: April 14, 2015Publication date: February 9, 2017Applicant: INDUSTRIAL MICORBES, INC.Inventors: Noah HELMAN, Elizabeth CLARKE, Derek GREENFIELD
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Publication number: 20160002681Abstract: The disclosure relates to recombinant microorganisms that exhibit an increased expression of an acyl carrier protein (ACP) resulting in production of fatty acid derivatives. The disclosure further relates to methods of using the recombinant microorganisms in fermentation cultures in order to produce fatty acid derivatives and related compositions.Type: ApplicationFiled: December 11, 2013Publication date: January 7, 2016Applicant: REG LIFE SCIENCES, LLCInventors: David SIMPSON, Bernardo DA COSTA, Mathew RUDE, Na TRINH, Emanuela POPOVA, Sankaranarayanan VENKITESWARAN, Noah HELMAN, Kevin HOLDEN
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Publication number: 20150299679Abstract: The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters. Further contemplated are recombinant host cells that express such variants, cell cultures comprising the recombinant host cells and fatty acid ester compositions produced by such recombinant host cells.Type: ApplicationFiled: March 15, 2013Publication date: October 22, 2015Applicant: REG Life Sciences, LLC.Inventors: Andrew M. SHUMAKER, Bernardo M. DA COSTA, Kevin HOLDEN, Louis G. HOM, Tarah S. BARON, Noah HELMAN
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Publication number: 20110124071Abstract: Provided are compositions and methods for producing hydrocarbons, including aldehydes, alkanes and alkenes. The hydrocarbons can be used in biofuels.Type: ApplicationFiled: November 17, 2010Publication date: May 26, 2011Applicant: LS9, IncInventors: Andreas Schirmer, Mathew Rude, Noah Helman
