Patents by Inventor Nobuko Muraki
Nobuko Muraki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8927273Abstract: The present invention provides a method for preparing a cytotoxic lymphocyte characterized in that the method comprises the step of carrying out at least one step selected from induction, maintenance and expansion of a cytotoxic lymphocyte using a medium containing serum and plasma at a total concentration of 0% by volume or more and less than 5% by volume, in the presence of fibronectin, a fragment thereof or a mixture thereof.Type: GrantFiled: August 19, 2004Date of Patent: January 6, 2015Assignee: Takara Bio Inc.Inventors: Mitsuko Ideno, Nobuko Muraki, Kinuko Ogawa, Masayuki Kishimoto, Tatsuji Enoki, Hiroaki Sagawa, Ikunoshin Kato
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Patent number: 8765469Abstract: A method for preparing lymphocytes characterized in that the method comprises the step of carrying out expansion in the presence of (a) fibronectin, a fragment thereof or a mixture thereof, (b) a CD3 ligand, and (c) a CD28 ligand.Type: GrantFiled: August 10, 2006Date of Patent: July 1, 2014Assignee: Takara Bio Inc.Inventors: Takahiro Marui, Kinuko Nagamine, Nobuko Muraki, Akiko Kato, Tatsuji Enoki, Hiroaki Sagawa, Ikunoshin Kato
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Patent number: 8216837Abstract: A method of producing lymphocytes characterized by comprising the step of culturing lymphocytes in the presence of a modified recombinant fibronectin fragment which has overlapping parts of the heparin-binding domain of fibronectin. This method makes it possible to achieve a high cell proliferation rate. The lymphocytes obtained thereby are appropriately usable in, for example, adoptive immunotherapy and, therefore, expected as highly useful in the clinical field. Moreover, a novel modified recombinant fibronectin fragment is provided.Type: GrantFiled: June 7, 2007Date of Patent: July 10, 2012Assignee: Takara Bio Inc.Inventors: Nobuko Muraki, Mitsuko Ideno, Kinuko Nagamine, Fuyuko Takashima, Eiji Kobayashi, Akiko Kato, Takahiro Marui, Hiroaki Sagawa, Tatsuji Enoki, Ikunoshin Kato
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Publication number: 20100255578Abstract: A method of producing lymphocytes characterized by comprising the step of culturing lymphocytes in the presence of a modified recombinant fibronectin fragment which has overlapping parts of the heparin-binding domain of fibronectin. This method makes it possible to achieve a high cell proliferation rate. The lymphocytes obtained thereby are appropriately usable in, for example, adoptive immunotherapy and, therefore, expected as highly useful in the clinical field. Moreover, a novel modified recombinant fibronectin fragment is provided.Type: ApplicationFiled: June 7, 2007Publication date: October 7, 2010Inventors: Nobuko Muraki, Mitsuko Ideno, Kinuko Nagamine, Fuyuko Takashima, Eiji Kobayashi, Akiko Kato, Takahiro Marui, Hiroaki Sagawa, Tatsuji Enoki, Ikunoshin Kato
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Publication number: 20090221077Abstract: The present invention provides a method for preparing a cytotoxic lymphocyte characterized in that the method comprises the step of carrying out at least one step selected from induction, maintenance and expansion of a cytotoxic lymphocyte using a medium containing serum and plasma at a total concentration of 0% by volume or more and less than 5% by volume, in the presence of fibronectin, a fragment thereof or a mixture thereof.Type: ApplicationFiled: August 19, 2004Publication date: September 3, 2009Inventors: Mitsuko Ideno, Nobuko Muraki, Kinuko Ogawa, Masayuki Kishimoto, Tatsuji Enoki, Hiroaki Sagawa, Ikunoshin Kato
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Patent number: 7361774Abstract: The present invention relates to a chalcone compound represented by the following general formula: wherein R1 and R2 are taken together with the carbon atom to which they are bound, respectively, to form a hydroxydimethyl hexane ring, or where R1 is a hydroxyl group, R2 is an isohexenyl group, a derivative thereof, or a salt thereof. Also, the present invention relates to a therapeutic agent or prophylactic agent for a disease requiring neuronal protection, suppression for nitrogen monoxide (NO) production, inhibition for aldose reductase or suppression for interleukin production, and a food, beverage or feed for treatment or prevention of the above-mentioned disease, characterized in that each comprises the above-mentioned compound as an effective ingredient.Type: GrantFiled: September 29, 2003Date of Patent: April 22, 2008Assignee: Takara Bio Inc.Inventors: Hiromu Ohnogi, Katsumi Sugiyama, Nobuko Muraki, Tatsuji Enoki, Hiroaki Sagawa, Ikunoshin Kato
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Publication number: 20080044498Abstract: The present invention relates to a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an insulin-mimetic action agent, a food, beverage, or feed for treating or preventing a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for enhancement of glucose uptake into a cell, and an agent for induction of an adipocyte differentiation, each comprising as an effective ingredient a processed product derived from a plant belonging to Umbelliferae.Type: ApplicationFiled: October 5, 2007Publication date: February 21, 2008Inventors: Tatsuji Enoki, Kinuko Ogawa, Hiromu Ohnogi, Katsumi Sugiyama, Nobuko Muraki, Hiroaki Sagawa, Ikunoshin Kato
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Publication number: 20080008773Abstract: The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring promotion of osteogenesis or enhancement of bone morphogenetic protein production, an agent for promotion of osteogenesis or an agent for enhancement of bone morphogenetic protein production, and a food, beverage or feed for promotion of osteogenesis or enhancement of bone morphogenetic protein production, characterized in that each comprises as an effective ingredient a processed product derived from a plant. Also, the present invention relates to a method for measuring an enhancing action for bone morphogenetic protein production, a method for screening a substance having an enhancing action for bone morphogenetic protein production, and a method for preparing a substance having an enhancing action for bone morphogenetic protein production, each method using a specified cell.Type: ApplicationFiled: June 27, 2007Publication date: January 10, 2008Inventors: Hiromu Ohnogi, Katsumi Sugiyama, Nobuko Muraki, Hiroaki Sagawa, Ikunoshin Kato
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Publication number: 20070092587Abstract: The present invention provides an extract obtainable by extracting a plant belonging to Umbelliferae, or a processed product thereof, with a water-containing alcohol; a process for preparing the extract; a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response and/or diabetic complications, characterized in that the therapeutic agent or prophylactic agent comprises as an effective ingredient the extract as defined above; an agent for an insulin-mimetic action, characterized in that the agent comprises as an effective ingredient the extract as defined above; a food, beverage or feed, comprising the extract as defined above; an agent for enhancing glucose uptake into a cell, characterized in that the agent comprises as an effective ingredient the extract as defined above; to an agent for inducing differentiation into an adipocyte, characterized in that the agent comprises as an effective ingredient the extract as defined above; and an inhibiType: ApplicationFiled: June 18, 2004Publication date: April 26, 2007Inventors: Hiromu Ohnogi, Katsumi Sugiyama, Nobuko Muraki, Tatsuji Enoki, Hiroaki Sagawa, Ikunoshin Kato
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Publication number: 20060216362Abstract: The present invention relates to a therapeutic agent and prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for an insulin-mimetic action, a food, beverage and feed for treating a preventing a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for enhancing glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, characterized in that each comprises as an effective ingredient a processed product derived from at least one plant selected from the group consisting of (a) a plant belonging to Tiliaceae, (b) a plant belonging to Zingiberaceae, (c) a plant belonging to Compositae, (d) a plant belonging to Liliaceae, and (e) a plant belonging to Polygonaceae.Type: ApplicationFiled: May 14, 2004Publication date: September 28, 2006Inventors: Tatsuji Enoki, Kinuko Ogawa, Hiromu Ohnogi, Nobuko Muraki, Yoko Kudo, Hiroaki Sagawa, Ikunoshin Kato
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Publication number: 20060039998Abstract: The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring promotion of osteogenesis or enhancement of bone morphogenetic protein production, an agent for promotion of osteogenesis or an agent for enhancement of bone morphogenetic protein production, and a food, beverage or feed for promotion of osteogenesis or enhancement of bone morphogenetic protein production, characterized in that each comprises as an effective ingredient a processed product derived from a plant. Also, the present invention relates to a method for measuring an enhancing action for bone morphogenetic protein production, a method for screening a substance having an enhancing action for bone morphogenetic protein production, and a method for preparing a substance having an enhancing action for bone morphogenetic protein production, each method using a specified cell.Type: ApplicationFiled: September 29, 2003Publication date: February 23, 2006Inventors: Hiromu Ohnogi, Katsumi Sugiyama, Nobuko Muraki, Hiroaki Sagawa, Ikunoshin Kato
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Publication number: 20060034949Abstract: The present invention relates to a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an insulin-mimetic action agent, a food, beverage, or feed for treating or preventing a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for enhancement of glucose uptake into a cell, and an agent for induction of an adipocyte differentiation, each comprising as an effective ingredient a processed product derived from a plant belonging to Umbelliferae.Type: ApplicationFiled: August 6, 2003Publication date: February 16, 2006Inventors: Tatsuji Enoki, Kinuko Ogawa, Hiromu Ohnogi, Katsumi Sugiyama, Nobuko Muraki, Hiroaki Sagawa, Ikunoshin Kato
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Publication number: 20050272809Abstract: The present invention relates to a novel chalcone compound represented by the following general formula: wherein R1 and R2 are taken together with the carbon atom to which they are bound, respectively, to form a hydroxydimethyl hexane ring, or where R1 is a hydroxyl group, R2 is an isohexenyl group, a derivative thereof, or a salt thereof. Also, the present invention relates to a therapeutic agent or prophylactic agent for a disease requiring neuronal protection, suppression for nitrogen monoxide (NO) production, inhibition for aldose reductase or suppression for interleukin production, and a food, beverage or feed for treatment or prevention of the above-mentioned disease, characterized in that each comprises the above-mentioned compound as an effective ingredient.Type: ApplicationFiled: September 29, 2003Publication date: December 8, 2005Inventors: Hiromu Ohnogi, Katsumi Sugiyama, Nobuko Muraki, Tatsuji Enoki, Hiroaki Sagawa, Ikunoshin Kato
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Publication number: 20050124575Abstract: Remedies or preventives, which are characterized by containing as the active ingredient at least one member selected from the group consisting of agar, agarose, high-molecular weight digestion products originating in agar and high-molecular weight digestion products originating in agarose, for diseases sensitive to the above active ingredients.Type: ApplicationFiled: April 14, 2003Publication date: June 9, 2005Applicant: Takara Bio Inc.Inventors: Eiji Nishiyama, Nobuko Muraki, Hiromu Ohnogi, Hiroaki Sagawa, Ikunoshin Kato
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Patent number: 6133238Abstract: 2,5-dihydroxytetrahydro-2-furancarboxylic acid represented by the following formula [I], its optically active substance or salt thereof.Type: GrantFiled: July 2, 1999Date of Patent: October 17, 2000Assignee: Takara Shuzo Co., Ltd.Inventors: Hiroaki Sagawa, Shinji Okuda, Nobuko Muraki, Nobuto Koyama, Katsushige Ikai, Ikunoshin Kato