Patents by Inventor Nobuko Uchida

Nobuko Uchida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENOME EDITING OF HUMAN NEURAL STEM CELLS USING NUCLEASES
    Publication number: 20230250423
    Abstract: The invention provides methods for generating a genetically modified human neural stem cell, genetically modified human neural stem cells, and pharmaceutical compositions comprising the genetically modified human neural stem cells. Also provided are associated kits. The invention also provides methods for preventing or treating a neurodegenerative disease or a neurological injury in a human subject using genetically modified human neural stem cells.
    Type: Application
    Filed: January 3, 2023
    Publication date: August 10, 2023
    Inventors: Matthew H. PORTEUS, Eric J. KILDEBECK, Daniel P. DEVER, Joseph T. CLARK, Ann TSUKAMOTO, Nobuko UCHIDA
  • Target populations of oligodendrocyte precursor cells and methods of making and using same
    Patent number: 10400214
    Abstract: This application provides for enriched target populations oligodendrocyte precursor cells (OPCs) that can differentiate into oligodendrocytes. The target OPCs may be expanded and optionally subjected to conditions to induce their differentiation into oligodendrocytes. The target OPCs and their progeny are useful for the treatment of disease associated with demyelination of central nervous system axons.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: September 3, 2019
    Assignee: BOCO SILICON VALLEY, INC.
    Inventors: Alexandra Capela, Nobuko Uchida
  • TARGET POPULATIONS OF OLIGODENDROCYTE PRECURSOR CELLS AND METHODS OF MAKING AND USING SAME
    Publication number: 20180187148
    Abstract: This application provides for enriched target populations oligodendrocyte precursor cells (OPCs) that can differentiate into oligodendrocytes. The target OPCs may be expanded and optionally subjected to conditions to induce their differentiation into oligodendrocytes. The target OPCs and their progeny are useful for the treatment of disease associated with demyelination of central nervous system axons.
    Type: Application
    Filed: November 17, 2017
    Publication date: July 5, 2018
    Inventors: Alexandra CAPELA, Nobuko UCHIDA
  • GENOME EDITING OF HUMAN NEURAL STEM CELLS USING NUCLEASES
    Publication number: 20170298348
    Abstract: The invention provides methods for generating a genetically modified human neural stem cell, genetically modified human neural stem cells, and pharmaceutical compositions comprising the genetically modified human neural stem cells. Also provided are associated kits. The invention also provides methods for preventing or treating a neurodegenerative disease or a neurological injury in a human subject using genetically modified human neural stem cells.
    Type: Application
    Filed: April 13, 2017
    Publication date: October 19, 2017
    Inventors: Matthew H. PORTEUS, Eric J. KILDEBECK, Daniel P. DEVER, Joseph T. CLARK, Ann TSUKAMOTO, Nobuko UCHIDA
  • Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
    Publication number: 20110070641
    Abstract: Enriched pancreatic stem and progenitor cell populations, and methods for identifying, isolating, and enriching for pancreatic stem cells using reagents that bind to cell surface markers are provided.
    Type: Application
    Filed: September 7, 2010
    Publication date: March 24, 2011
    Inventors: Nobuko Uchida, Ann Tsukamoto, Stanley Tamaki, Alexandra Capela, Tim Austin
  • TARGET POPULATIONS OF OLIGODENDROCYTE PRECURSOR CELLS AND METHODS OF MAKING AND USING SAME
    Publication number: 20100158878
    Abstract: This application provides for enriched target populations oligodendrocyte precursor cells (OPCs) that can differentiate into oligodendrocytes. The target OPCs may be expanded and optionally subjected to conditions to induce their differentiation into oligodendrocytes. The target OPCs and their progeny are useful for the treatment of disease associated with demyelination of central nervous system axons.
    Type: Application
    Filed: December 23, 2009
    Publication date: June 24, 2010
    Inventors: Alexandra Capela, Nobuko Uchida
  • Enriched Central Nervous System Stem Cell and Progenitor Cell Populations, and Methods For Identifying, Isolating and Enriching For Such Populations
    Publication number: 20100086998
    Abstract: Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided.
    Type: Application
    Filed: September 9, 2009
    Publication date: April 8, 2010
    Inventors: David W. Buck, Nobuko Uchida, Irving Weissman
  • Methods for the treatment of lysosomal storage disorders
    Publication number: 20100028305
    Abstract: Provided herein are methods for the treatment of lysosomal storage disorders characterized by a missing or defective secreted lysosomal enzyme. Such lysosomal storage disorders include, but are not limited to neuronal ceroid lipofuscinoses. The disclosed methods involve the transplantation of human multipotent neural stem cells into the CNS of patients suffering from the lysosomal storage disorder. Also provided herein are methods of reversing or slowing the progression of neurodegeneration in patients suffering from or at risk of developing neuronal ceroid lipofuscinoses.
    Type: Application
    Filed: January 4, 2006
    Publication date: February 4, 2010
    Inventors: Nobuko Uchida, Yakop Jacoba, Stanley Tamaki
  • Enriched Pancreatic Stem Cell and Progenitor Cell, Populations, and Methods For Identifying, Isolating and Enriching For Such Populations
    Publication number: 20100003749
    Abstract: Enriched pancreatic stem and progenitor cell populations, and methods for identifying, isolating, and enriching for pancreatic stem cells using reagents that bind to cell surface markers are provided.
    Type: Application
    Filed: July 30, 2009
    Publication date: January 7, 2010
    Inventors: Nobuko Uchida, Ann Tsukamoto, Stanley Tamaki, Alexandra Capela, Tim Austin
  • Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
    Patent number: 7381561
    Abstract: Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagents that bind to cell surface markers are provided.
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: June 3, 2008
    Assignee: StemCells California, Inc.
    Inventors: Nobuko Uchida, Alexandra Capela
  • Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
    Publication number: 20070238171
    Abstract: Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided.
    Type: Application
    Filed: October 31, 2006
    Publication date: October 11, 2007
    Inventors: David Buck, Nobuko Uchida, Irving Weissman
  • Enriched Pancreatic Stem Cell and Progenitor Cell Populations, and Methods for Identifying, Isolating and Enriching for Such Populations
    Publication number: 20070212732
    Abstract: Enriched pancreatic stem and progenitor cell populations, and methods for identifying, isolating and enriching for pancreatic stem cells using reagents that bind to cell surface markers are provided.
    Type: Application
    Filed: August 27, 2004
    Publication date: September 13, 2007
    Inventors: Nobuko Uchida, Ann Tsukamoto, Stanley Tamaki, Alexandra Capela, Tim Austin
  • Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
    Patent number: 7217565
    Abstract: Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: May 15, 2007
    Assignee: StemCells California, Inc.
    Inventors: David W. Buck, Nobuko Uchida, Irving Weissman
  • Compositions of enriched central nervous system stem cell and progenitor cell populations
    Patent number: 7153686
    Abstract: Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: December 26, 2006
    Assignee: Stemcells California, Inc.
    Inventors: Nobuko Uchida, David W. Buck, Irving Weissman
  • Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
    Publication number: 20060205072
    Abstract: Enriched pancreatic stem and progenitor cell populations, and methods for identifying, isolating and enriching for pancreatic stem cells using reagents that bind to cell surface markers are provided.
    Type: Application
    Filed: August 27, 2004
    Publication date: September 14, 2006
    Inventors: Nobuko Uchida, Ann Tsukamoto, Stanley Tamaki, Alexandra Capela, Tim Austin
  • In vivo screening methods using enriched neural stem cells
    Patent number: 7105150
    Abstract: Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: September 12, 2006
    Assignee: StemCells California, Inc.
    Inventors: David W. Buck, Nobuko Uchida, Irving Weissman
  • Methods for the treatment of lysosomal storage disorders
    Publication number: 20060147431
    Abstract: Provided herein are methods for the treatment of lysosomal storage disorders characterized by a missing or defective secreted lysosomal enzyme. Such lysosomal storage disorders include, but are not limited to neuronal ceroid lipofuscinoses. The disclosed methods involve the transplantation of human multipotent neural stem cells into the CNS of patients suffering from the lysosomal storage disorder. Also provided herein are methods of reversing or slowing the progression of neurodegeneration in patients suffering from or at risk of developing neuronal ceroid lipofuscinoses.
    Type: Application
    Filed: January 4, 2006
    Publication date: July 6, 2006
    Inventors: Nobuko Uchida, Yakop Jacobs, Stanley Tamaki
  • Use of collagenase in the preparation of neural stem cell cultures
    Patent number: 7049141
    Abstract: The invention provides a method for using collagenase to dissociate neural stem cells in neural stem cell cultures. The collagenase treatment results in an increased cell viability and an increased number of proliferated neural stem cells over time.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: May 23, 2006
    Assignee: StemCells California, Inc.
    Inventor: Nobuko Uchida
  • Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
    Publication number: 20060099651
    Abstract: Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagents that bind to cell surface markers are provided.
    Type: Application
    Filed: August 27, 2003
    Publication date: May 11, 2006
    Inventors: Nobuko Uchida, Alexandra Capela
  • Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
    Patent number: 7037719
    Abstract: Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: May 2, 2006
    Assignee: StemCells California, Inc.
    Inventors: David W. Buck, Nobuko Uchida, Irving Weissman