Abstract: The present invention relates to a compound represented by formula (1): (wherein, R1, R2, R3 and R4 respectively and independently represent a hydrogen atom or a C1-6 alkyl group, and n represents an integer of 1 or 2) and a production process thereof, as well as an antioxidant that contains the compound as its active ingredient, and a kidney disease treatment agent, cerebrovascular disorder treatment agent, retina oxidative disorder inhibitor and lipoxygenase inhibitor that contain the antioxidant.

Abstract: The present invention is directed to compounds represented by the formula (1): B-D-Z (1), wherein B represent the following formula (B-1), A represents an optionally substituted imidazole or pyrazole group; E represents the following formula (1a): X represents an oxygen atom, the formula: SOu, or the formula: N—R9; Y represents a carbon atom or a nitrogen atom; D represents an oxygen atom, a sulfur atom or the formula (1a); Z represents (a chroman-2-yl group, a chroman-4-yl group, a 2,3-dihydrobenzofuran-2-yl group, a 2,3-dihydrobenzofuran-3-yl group, etc.) which is substituted with NHR10 or OR11)] or pharmaceutically acceptable salts thereof, and to antioxidants, therapeutic agents for kidney diseases or cerebrovascular disorder, and retinal oxidative damage inhibitors, which include the compounds as the active ingredient.

Abstract: The present invention is directed to compounds represented by the formula (1): B-D-Z (1), wherein B represent the following formula (B-1), (B-2) or (B-3); A represents an optionally substituted imidazole or pyrazole group; E represents the following formula (1a); X represents an oxygen atom, the formula: SOu, or the formula: N—R9; Y represents a carbon atom or a nitrogen atom; D represents an oxygen atom, a sulfur atom or the formula (1a); Z represents (a chroman-2-yl group, a chroman-4-yl group, a 2,3-dihydrobenzofuran-2-yl group, a 2,3-dihydrobenzofuran-3-yl group, etc.) which is substituted with NHR10 or OR11)] or pharmaceutically acceptable salts thereof, and to antioxidants, therapeutic agents for kidney diseases or cerebrovascular disorder, and retinal oxidative damage inhibitors, which include the compounds as the active ingredient.

Abstract: The present invention is directed to compounds represented by the formula (1): B-D-Z??(1) [wherein B represent the following formula (B-1), (B-2) or (B-3); A represents an optionally substituted imidazole or pyrazole group; E represents the following formula (1a): X represents an oxygen atom, the formula: SOu, or the formula: N—R9; Y represents a carbon atom or a nitrogen atom; D represents an oxygen atom, a sulfur atom or the formula (1a); Z represents (a chroman-2-yl group, a chroman-4-yl group, a 2,3-dihydrobenzofuran-2-yl group, a 2,3-dihydrobenzofuran-3-yl group, etc.) which is substituted with NHR10 or OR11)] or pharmaceutically acceptable salts thereof, and to antioxidants, therapeutic agents for kidney diseases or cerebrovascular disorder, and retinal oxidative damage inhibitors, which include the compounds as the active ingredient.

Abstract: The present invention relates to a compound represented by formula (1): (wherein, R1, R2, R3 and R4 respectively and independently represent a hydrogen atom or a C1-6 alkyl group, and n represents an integer of 1 or 2) and a production process thereof, as well as an antioxidant that contains the compound as its active ingredient, and a kidney disease treatment agent, cerebrovascular disorder treatment agent, retina oxidative disorder inhibitor and lipoxygenase inhibitor that contain the antioxidant.

Abstract: The present invention relates to a compound represented by formula (1): (wherein R represents a hydrogen atom or a C1-6 alkyl group which may be substituted, A represents an imidazolyl group or a pyrazolyl group, B represents a group represented by the following formula: (wherein R5 and R6 each independently represents a hydrogen atom, a cyano group, a hydroxyl group, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, or the like, k represents 0 or an integer of 1 to 15, and R5 and R6 may be identical or different from each other, when k is 2 or more), and Z represents a substituted chroman-2-yl group, a substituted 2,3-dihydrobenzofuran-2-yl, a substituted thiochroman-2-yl group, a substituted 2,3-dihydrobenzothiophene-2-yl group, or a substituted 1,3-benzoxathiol-2-yl group).

Abstract: Thieno[2,3-d]pyrimidine compounds of general formula (1) useful as drugs having a cGMP-specific phosphodiesterase inhibiting effect and the preparation thereof wherein Q is formula: (CH2)n—N(r1)—C(r2) (r3), CH═CH—CH═CH, or (CH2)m which is bonded to a and b; R1 is hydrogen or C1-C6 alkyl; R2 is C3-C8 cycloalkyl optionally substituted with G1, phenyl optionally substituted with G2, or a saturated or unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, O and S and being optionally substituted with G3; and R3 is a saturated or unsaturated heretocyclic group having 1 to 4 heteroatoms selected from N, O and S and being optionally substituted with G3 or (CH2)kC(═O)R4 or CH═CHC(O)R4.

Abstract: Phenylazole compounds represented by general formula (1) or pharmaceutically acceptable salts thereof and drugs for hyperlipemia which contain these compounds as the active ingredient, wherein A represents imidazolyl, pyrazolyl, etc.; B represents (1a) or (1b) (wherein R2 and R3 represent each hydrogen, C1-6 alkyl, etc; and k is 0 or an integer of 1 to 15); Y represents O, S, a bond, etc.; and Z represents an optionally substituted and saturated or unsaturated heterocycle containing 1 to 4 N, O or S atoms. Among all, compounds wherein Z is substituted chroman-2-yl, 2,3-dihydrobenzofuran-2-yl, etc. have an effect of inhibiting the formation of lipid peroxides too.

Abstract: The present invention is to provide novel imidazole derivatives effectual as an antihyperlipemic agent and therapeutic and preventive drugs for arteriosclerosis, and to provide methods for manufacturing the said derivatives.More particularly, the present invention is directed to the compounds represented by the following general formula [I]; ##STR1## wherein R.sup.1 is hydrogen or lower alkyl, n is 0 or 1, X is N-r.sup.1 wherein r.sup.1 is hydrogen or lower alkyl, O, S, SO, SO.sub.2, CH.sub.2, CH(CH.sub.3), CONH or C(r.sup.2).dbd.NO wherein r.sup.2 is hydrogen or lower alkyl, m is 0 or an integer of from 1 to 12, and A is methyl or a group represented by the following general formula; ##STR2## wherein Y is N-r.sup.3 wherein r.sup.3 is hydrogen or lower alkyl, N(r.sup.4)SO.sub.2 wherein r.sup.4 is hydrogen or lower alkyl, O, S, SO, SO.sub.2, CH.sub.2, CH(CH.sub.3), CONH or C(r.sup.5).dbd.NO wherein r.sup.5 is hydrogen or lower alkyl, R.sup.2 is a halogen, a lower alkyl, a lower alkoxy, a cycloalkyl or COOr.

Abstract: The present invention is directed to (R)-(-)-4,5-dihydro-5-methyl-6-?4-?(2-propyl-3-oxo-1-cyclohexenyl)amino!ph enyl!-3(2H)-pyridazinone, the crystalline form thereof and a method for manufacturing the said compound and the said crystalline form.The compound of the present invention has excellent inhibitory effect on platelet aggregation while giving less side effect, and therefore, it is useful to utilize the compound as an antithrombotic drug. In addition, the compound of the present invention has bronchodialatic effect as well, and it is therefore useful to utilize the compound for chemotherapy of chronic obstructive lung disease, such as asthma and bronchitis.Moreover, the compound of the present invention is useful for chemotherapy of the diseases relating to the concentration of cAMP in cells, such as hypertension, ulcer, diabetes mellitus and cancer.Again, crystalline form of the said compound is the most suitable form in order to supply stable and homogeneous bulk thereof.

Abstract: A preventive agent for platelet aggregation comprising a compound represented by the following general formula [I]: ##STR1## wherein Y is --CH.sub.2 CH.sub.2 -- or --CH.sub.2 CH.sub.2 CH.sub.2 --, R is hydrogen or methyl, and ---------- represents a single bond or a double bond, or a pharmaceutically-compatible complex thereof as the active ingredient, is disclosed.

Abstract: A multicolor thermosensitive image transfer sheet comprising (i) a substrate and (ii) a plurality of thermofusible ink layers, formed thereon side by side, each thermofusible ink layer comprising a thermofusible ink component having a different color and a different surface tension from the colors and surface tensions of the ink components in the other thermofusible ink layers, and a multicolor thermosensitive image transfer recording method of obtaining multicolored images by transferring imagewise the thermofusible ink layers of the multicolor thermosensitive image transfer recording medium to a receiving sheet in the sequential order from the highest to the lowest, or from the lowest to the highest, critical surface tension of the thermofusible ink components are provided.

Abstract: The present invention relates to a compound having the formula below which have an excellent cardiotonic action: ##STR1## wherein Y represents C.sub.1-4 alkylene which may be substituted by C.sub.1-18 alkyl, C.sub.1-5 alkoxy, C.sub.1-5 alkylthio C.sub.1-5 alkyl, C.sub.1-5 alkoxycarbonyl or benzyl, or ##STR2## where each r.sup.1 and r.sup.2 represents hydrogen, C.sub.1-18 alkyl, C.sub.1-5 alkoxy, C.sub.1-5 alkylthio C.sub.1-5 alkyl, C.sub.1-5 alkoxycarbonyl or benzyl); andR.sub.1 represents hydrogen, C.sub.1-5 alkyl which may be substituted by C.sub.1-5 alkoxy, acetyl or C.sub.2-5 alkenyl; andR.sub.2 represents hydrogen or methyl; andeach R.sub.3 and R.sub.4 represents hydrogen, halogen, hydroxy, C.sub.1-5 alkyl, or C.sub.1-5 alkoxy; andR.sub.5 represents hydrogen or C.sub.1-5 alkyl which may be substituted by hydroxy; andR.sub.4 and R.sub.5 may form ring by joining each other; and represents single or double bond.

Abstract: A multicolor thermosensitive image transfer sheet comprising (i) a substrate and (ii) a plurality of thermofusible ink layers, formed thereon side by side, each thermofusible ink layer comprising a thermofusible ink component having a different color and a different surface tension from the colors and surface tensions of the ink components in the other thermofusible ink layers, and a multicolor thermosensitive image transfer recording method of obtaining multicolored images by transferring imagewise the thermofusible ink layers of the multicolor thermosensitive image transfer recording medium to a receiving sheet in the sequential order from the highest to the lowest, or from the lowest to the highest, critical surface tension of the thermofusible ink components are provided.

Abstract: A multicolor thermosensitive image transfer sheet comprising (i) a substrate and (ii) a plurality of thermofusible ink layers, formed thereon side by side, each thermofusible ink layer comprising a thermofusible ink component having a different color and a different surface tension from the colors and surface tensions of the ink components in the other thermofusible ink layers, and a multicolor thermosensitive image transfer recording method of obtaining multicolored images by transferring imagewise the thermofusible ink layers of the multicolor thermosensitive image transfer recording medium to a receiving sheet in the sequential order from the highest to the lowest, or from the lowest to the highest, critical surface tension of the thermofusible ink components are provided.

Abstract: A thermosensitive image transfer recording medium comprising a support material; an image transfer layer formed on the support material, comprising a fine porous network structure made of a resin comprising cellulose acetate butyrate; a non-volatile oily material which is contained in the fine porous network structure, and which does not dissolve the resin of the fine porous network structure; and a thermofusible ink composition which is held in the fine porous network structure, comprising (a) a thermofusible wax material is solid at room temperature, and (b) a colorant.

Abstract: A thermosensitive image transfer recording medium comprising a support material and a thermofusible ink layer formed thereon, comprising an image gradation control agent, a coloring agent and a carrier material for holding the coloring agent at normal temperatures and to carry the coloring agent, upon application of heat, out of said thermofusible ink layer for image formation, all of which are contained in a fine porous resin structure.

Abstract: A thermosensitive image transfer recording medium comprising a support material and a thermofusible ink layer formed thereon, which thermofusible ink layer comprises a dye component, a binder agent and a pigment having a needle-like crystal form, which is dispersed in a network form throughout the thermofusible ink layer.

Abstract: An apparatus for developing a latent electrostatic image formed on a photoconductive recording material in a dry type electrophotographic copying machine typically employing a one-component type developer comprises a conductive electrode held in contact with the developer. The electrode is connected to a power source through a switching device and serves to charge the developer to a predetermined polarity with a predetermined potential before the latent image is developed. In this way, the latent image can be developed selectively as either a normal image or a reverse image quite easily.

Abstract: A photoconductive drum or sheet is movable relative to a developing electrode which is biased to a voltage which prevents smearing of the background areas of the copy. A sensing electrode is disposed upstream of the developing electrode in the direction of movement of the drum or sheet which senses the voltage on the drum or sheet. The sensing electrode is provided in a plurality of independent segments, and a computing circuit selects the voltage on the segment which is lowest in magnitude and which corresponds to a background area of the copy and applies the biasing voltage to the developing electrode in dependence on the sensed voltage. An auxiliary electrode is provided so that the combination of the sensing electrode and the auxiliary electrode is coextensive with the drum or sheet in a direction perpendicular to the movement thereof to prevent streaking of the copy.