Patents by Inventor Nobuo Nakabayashi
Nobuo Nakabayashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100040666Abstract: Disclosed are a method for controlling the elution of a drug from a stent and a drug-eluting stent capable of reducing the restenosis rate after therapy. A coating composition for a drug-eluting stent comprising an endothelin receptor antagonist and a copolymer of 2-methacryloyloxyethyl phosphorylcholine and n-butyl methacrylate. The elution of the endothelin receptor antagonist from the coating composition can be controlled by varying the ratio of 2-methacryloyloxyethyl phosphorylcholine to n-butyl methacrylate in the copolymer.Type: ApplicationFiled: May 1, 2006Publication date: February 18, 2010Inventors: Hiroshi Azuma, Yasunari Nimi, Yasuhiko Jwasaki, Nobuo Nakabayashi
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Publication number: 20060217276Abstract: Contact lens wetting solutions for reducing friction between the contact lens and ocular tissues, and maintaining such effect for a long time, are disclosed. The wetting solution is composed only of a particular ratio of a lubricant composed of copolymer (A) obtained by polymerizing a monomer composition comprising 2-(meth)acryloyloxyethyl phosphorylcholine and alkyl(meth)acrylate, a buffer, an inorganic chloride, a preservative, a chelating agent, and water. The copolymer (A) has a weight average molecular weight of 100,000 to 1,000,000, and satisfies the formula 80?N×R?240, provided that 4?N?18 and 10%?R?60%, wherein N stands for the carbon number of the alkyl group in monomer Y constituting copolymer (A), and R stands for a molar fraction of the unit derived from monomer Y with respect to the sum of the units derived from monomers X and Y.Type: ApplicationFiled: June 8, 2006Publication date: September 28, 2006Applicants: NOF Corporation, Nobuo Nakabayashi, Kazuhiko IshiharaInventors: Motohiro Mitani, Ryota Ando, Hirofumi Irie, Ken Suzuki, Nobuo Nakabayashi, Kazuhiko Ishihara
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Patent number: 7108787Abstract: A modified hollow-fiber membrane which has improved surface hydrophilicity without increasing the amount of components released therefrom, is less apt to interact with living-body components, does not adsorb proteins, and is less apt to deteriorate in performance. The hollow-fiber membrane has a copolymer of 2-methacryloyloxyethylphosphorylcholine and other polymerizable vinyl monomer held on a surface of the membrane, the copolymer being present on the surface in a higher concentration than in other parts of the membrane. The modified hollow-fiber membrane is useful in medical applications such as hemodialysis and blood filtration and in the medical industry, food industry etc.Type: GrantFiled: July 27, 2001Date of Patent: September 19, 2006Assignee: NOF CorporationInventors: Nobuo Nakabayashi, Kazuhiko Ishihara, Shinji Miyazaki, Kazuo Imamura, Ken Suzuki, Koji Kamenosono
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Patent number: 6878352Abstract: Recovery of air bag inflator metal cases. An inflator processing apparatus configured to process a gas-generating chemical-containing inflator for automobile air bags, by heating the inflator to a temperature not lower than an operating temperature of the chemical to facilitate recovery of the metal inflator case. In the apparatus, a protective metal partition wall is provided between an inner surface of a wall of an inflator-processing furnace and the chemical-containing inflator. This prevents damage to the refractory furnace wall, and also prevents melting of the metal inflator case, which could otherwise be occasioned by the chemical during thermal processing of the inflator containing the gas-generating chemical.Type: GrantFiled: September 29, 1998Date of Patent: April 12, 2005Assignee: Daicel Chemical Industries, Ltd.Inventors: Mitsuhiko Fukabori, Nobuo Nakabayashi, Kanshi Sakai, Yasumitsu Suzuki, Norio Yoshitake, Masato Fujioka
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Patent number: 6828028Abstract: A medical material having a surface which is safe and excellent in stability with the lapse of time and has a high durability as needed in establishing a long-lasting surface lubricity in a wet state and an excellent compatibility with blood, and a method for producing the same. These materials are obtained by forming a coating layer with a coating material containing a polymeric substance (A) having a heterocyclic group represented by the formula (1) on at least a part of a surface of a medical material base, and then ring-opening the heterocyclic group remaining in the coating layer by a nucleophilic compound (N): wherein X represents O, NH or S; and R1 represents H or CH3.Type: GrantFiled: January 25, 2002Date of Patent: December 7, 2004Assignee: NOF CorporationInventors: Hiroki Fukui, Ken Suzuki, Kenshiro Shuto, Nobuyuki Yamamoto, Kazuhiko Ishihara, Nobuo Nakabayashi
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Publication number: 20040122128Abstract: In order to suppress adhesion of oral contamination substances such as protein and oral bacteria causing oral disorders such as ozostomia on a surface of a dental prosthesis, so as to prevent a biofilm such as dental plaque from being formed thereon, the coating material composition for a dental prosthesis comprises 1 to 150 g/l of a copolymer of 2-methacryloyloxyethylphosphorylcholine and a (meth)acrylate contained in at least one solvent selected from water, ethanol, propanol, butanol, pentanol and acetone, an amount of the 2-methacryloyloxyethylphosphorylcholine component in the copolymer being 3 to 90% by mole.Type: ApplicationFiled: December 11, 2003Publication date: June 24, 2004Applicant: GC CorporationInventors: Nobuo Nakabayashi, Tatsunosuke Miyano, Tomohiro Kumagai
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Patent number: 6706260Abstract: A wound-covering agent containing a polymer having a group represented by formula (I) (wherein R1, R2 and R3 are the same or different and each represents hydrogen atom or C1-4 alkyl, and m is an integer of 2 to 4); a wound-covering material containing the preparation; and a method of wound healing which comprises the step of covering the wound of a subject with the wound-covering material to protect the wound.Type: GrantFiled: January 5, 2001Date of Patent: March 16, 2004Assignees: NOF CorporationInventors: Shinji Tanaka, Ken Suzuki, Kenshiro Shuto, Akio Hayashi, Nobuo Nakabayashi, Kazuhiko Ishihara
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Publication number: 20040045897Abstract: A modified hollow-fiber membrane which has improved surface hydrophilicity without increasing the amount of components released therefrom, is less apt to interact with living-body components, does not adsorb proteins, and is less apt to deteriorate in performance. The hollow-fiber membrane has a copolymer of 2-methacryloyloxyethylphosphorylcholine and other polymerizable vinyl monomer held on a surface of the membrane, the copolymer being present on the surface in a higher concentration than in other parts of the membrane. The modified hollow-fiber membrane is useful in medical applications such as hemodialysis and blood filtration and in the medical industry, food industry etc.Type: ApplicationFiled: June 2, 2003Publication date: March 11, 2004Inventors: Nobuo Nakabayashi, Kazuhiko Ishihara, Shinji Miyazaki, Kazuo Imamura, Ken Suzuki, Koji Kamenosono
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Publication number: 20030186825Abstract: Contact lens wetting solutions for reducing friction between the contact lens and ocular tissues, and maintaining such effect for a long time, are disclosed. The wetting solution is composed only of a particular ratio of a lubricant composed of copolymer (A) obtained by polymerizing a monomer composition comprising 2-(meth)acryloyloxyethyl phosphorylcholine and alkyl(meth)acrylate, a buffer, an inorganic chloride, a preservative, a chelating agent, and water. The copolymer (A) has a weight average molecular weight of 100,000 to 1,000,000, and satisfies the formula 80≦N×R≦240, provided that 4≦N≦18 and 10%≦R≦60%, wherein N stands for the carbon number of the alkyl group in monomer Y constituting copolymer (A), and R stands for a molar fraction of the unit derived from monomer Y with respect to the sum of the units derived from monomers X and Y.Type: ApplicationFiled: February 21, 2003Publication date: October 2, 2003Inventors: Motohiro Mitani, Ryota Ando, Hirofumi Irie, Ken Suzuki, Nobuo Nakabayashi, Kazuhiko Ishihara
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Patent number: 6270788Abstract: A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using methacrylate or acrylate monomers with a functional group (primary amino group) for subsequent attachment of heparin. Synthesis of the copolymer coating is carried out using the proper proportion of hydrophobic monomer/hydrophilic monomer/functional monomer in order to optimize the solubility of the copolymer in alcohol, its insolubility in water (before and after heparin coupling), the heparin coupling efficacy and heparin bioactivity. Once the copolymer coating is fashioned, a medical article is coated with it. The coating is thereafter dried and heparin attached. In such a manner the present invention provides for a method for making a biocompatible medical article, and preferably, a blood compatible medical article.Type: GrantFiled: October 4, 1999Date of Patent: August 7, 2001Assignee: Medtronic INCInventors: Edouard Koulik, Larik Vincent, Patrick Cahalan, Eric Fogt, Kazuhiko Ishihara, Nobuo Nakabayashi
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Patent number: 6258371Abstract: A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using methacrylate or acrylate monomers with a functional group (primary amino group) for subsequent attachment of heparin. Synthesis of the copolymer coating is carried out using the proper proportion of hydrophobic monomer/hydrophilic monomer/functional monomer in order to optimize the solubility of the copolymer in alcohol, its insolubility in water (before and after heparin coupling), the heparin coupling efficacy and heparin bioactivity. Once the copolymer coating is fashioned, a medical article is coated with it. The coating is thereafter dried and heparin attached. In such a manner the present invention provides for a method for making a biocompatible medical article, and preferably, a blood compatible medical article.Type: GrantFiled: April 3, 1998Date of Patent: July 10, 2001Assignee: Medtronic IncInventors: Edouard Koulik, Larik Vincent, Patrick Cahalan, Eric Fogt, Kazuhiko Ishihara, Nobuo Nakabayashi
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Patent number: 6214957Abstract: Solubilizers, emulsifiers and dispersing agents having the effects of moisturizing the skin when used as washing agents and having the character of elevating the concentration of a material to be solubilized, emulsified or dispersed in solvents including water as compared with the case where the material is employed alone, or elevating the apparent concentration of a material to be emulsified or dispersed in solvents by increasing homogeneity of the emulsion or dispersion which contain as the active ingredient polymers obtained by polymerizing monomer compositions containing at least one hydrophilic monomer (a) having a group represented by general formula (1) in the side chain, wherein R1, R2 and R3 represent each H or C1-4 alkyl.Type: GrantFiled: January 29, 1999Date of Patent: April 10, 2001Assignees: NOF Corporation, Japan Science Technology CorporationInventors: Daijiro Shiino, Kazunori Waki, Nobuo Nakabayashi, Kazuhiko Ishihara
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Patent number: 6204324Abstract: A method for producing an aqueous solution of a polymer having a phosphorylcholine group in which a polymerizable composition containing a polymerizable monomer having the phosphorylcholine group represented by the formula (1) is polymerized in the presence of a non-metal polymerization initiator soluble in a water-containing medium, to obtain a crude polymer aqueous solution, and the crude polymer aqueous solution is purified with a separation membrane, and an aqueous solution of the polymer having the phosphorylcholine group obtained by the method and having not more than 2000 ppm of impurities.Type: GrantFiled: December 2, 1996Date of Patent: March 20, 2001Assignees: NOF Corporation, Japan Science and Technology CorporationInventors: Kenshiro Shuto, Kazuo Matsuyama, Nobuo Nakabayashi, Kazuhiko Ishihara
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Patent number: 5977257Abstract: A high molecular material and a medical material which is a mixed material containing a copolymer A produced by copolymerization of a monomer composition containing a monomer having a side chain represented by the formula (1) ##STR1## (R.sup.1, R.sup.2, R.sup.3 ; H or a C1-4 alkyl group) and a hydrophobic monomer, and one or more sorts of hydrophobic polymer B other than the copolymer A; wherein structure of said mixed material shows phase separation in which domains of several hundred micrometers or less in size consisting of the copolymer A are uniformly distributed in a phase consisting of said hydrophobic polymer B. A liquid high molecular composition in which the copolymer A and the hydrophobic polymer B are dissolved in a mixed solvent consisting of a halogenated hydrocarbon solvent and a lower alcohol solvent, which has turbidity of 60% or less.Type: GrantFiled: October 28, 1997Date of Patent: November 2, 1999Assignees: NOF Corporation, Japan Science and Technology CorporationInventors: Kazunori Waki, Daijiro Shiino, Kazuo Matsuyama, Nobuo Nakabayashi, Kazuhiko Ishihara
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Patent number: 5879663Abstract: There is provided a dental composition for relieving dentin hypersensitivity, which occludes dentinal tubules having an opening on the surface of dentin to relieve dentin hypersensitivity thereby to give an immediate relieving effect and to maintain the relieving effect for a long time.The dental composition for relieving dentin hypersensitivity, which comprises (A) a low molecular weight compound which can produce a precipitate which is hardly soluble in water when it reacts with a calcium compound, or which comprises the above component (A), (B) a calcium compound and/or (C) an aqueous polymer emulsion having a particle size smaller than that of a dentinal tubule and forming an agglomerate or a hardly soluble gel larger than the diameter of a dentinal tubule when it reacts with a calcium compound.Type: GrantFiled: August 7, 1996Date of Patent: March 9, 1999Assignees: Sun Medical Co., Ltd., Nobuo NakabayashiInventors: Nobuo Nakabayashi, Takashi Yamamoto, Yasukazu Saimi, Masami Arata, Harumi Tanaka
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Patent number: 5766328Abstract: There is provided a dental composition for relieving dentin hypersensitivity comprising (A) an aqueous emulsion component which contains, as emulsion particles, polymer particles having a diameter smaller than that of a dentinal tubule and forming an agglomerate larger than the diameter of a dentinal tubule when they react with a calcium compound, and (B) a water-soluble organic acid component or a water-soluble salt component thereof, a calcium salt of the organic acid being insoluble or hardly soluble in water. Using this composition, dentinal tubules open to the surface of dentin are occluded to relieve dentin hypersensitivity immediately and lastingly.Type: GrantFiled: January 24, 1997Date of Patent: June 16, 1998Assignees: Sun Medical Co., Ltd., Nobuo NakabayashiInventors: Nobuo Nakabayashi, Takashi Yamamoto, Yasukazu Saimi, Masami Arata, Harumi Tanaka
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Patent number: 5658561Abstract: A method of producing a material bearing zwitterionic groups, such as phosphoryl choline groups, which comprises treating at least the surface of a substrate with a solution or dispersion of a polymer grafter with zwitterionic groups, and material produced by the method. The method is suitable for producing materials for use in contact with blood and in particular a regenerated cellulose membrane.Type: GrantFiled: January 24, 1995Date of Patent: August 19, 1997Assignee: Biocompatibles LimitedInventors: Nobuo Nakabayashi, Kazuhiko Ishihara
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Patent number: 5629361Abstract: An emulsion of a polymer, in which the polymer comprises (a) a recurring unit derived from a (meth)acrylate and (b) a recurring unit derived from a vinyl compound having a group of --SO.sub.3 R in which R is a hydrogen atom, an alkali metal atom or ammonium ion. The emulsion forms a film on an adherend to decrease the infiltration into the adherend, exhibits an adhesion force to a hydroxyapatite structure, a cement, a metal or a mineral when it is applied thereto to form a film by only drying around room temperature without washing it with water, and exhibits excellent affinity to a radical-polymerizable acrylic resin composition.Type: GrantFiled: May 31, 1995Date of Patent: May 13, 1997Assignees: Mitsui Petrochemical Industries, Ltd., Nobuo NakabayashiInventors: Nobuo Nakabayashi, Kazuhiko Ishihara, Yasukazu Saimi
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Patent number: 5554669Abstract: An emulsion of a polymer, in which the polymer comprises (a) a recurring unit derived from a (meth)acrylate and (b) a recurring unit derived from a vinyl compound having a group of --SO.sub.3 R in which R is a hydrogen atom, an alkali metal atom or ammonium ion. The emulsion forms a film on an adherend to decrease the infiltration into the adherend, exhibits an adhesion force to a hydroxyapatite structure, a cement, a metal or a mineral when it is applied thereto to form a film by only drying around room temperature without washing it with water, and exhibits excellent affinity to a radical-polymerizable acrylic resin composition.Type: GrantFiled: October 21, 1994Date of Patent: September 10, 1996Assignees: Mitsui Petrochemical Industries, Ltd., Nobuo NakabayashiInventors: Nobuo Nakabayashi, Kazuhiko Ishihara, Yasukazu Saimi
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Patent number: 5468475Abstract: The cosmetic composition of this invention which is a 2-methacryloyloxyethylphosphorylcholine polymer (Poly MPC) in a preferable amount of 0.001% to 10% by weight based on the total weight of the cosmetic composition. The cosmetic composition can repair damage to the skin and hair, such as dryness, loss of luster, etc. and enhance the moisture preservation capability thereof. It also has a good feel when applied.Type: GrantFiled: November 15, 1993Date of Patent: November 21, 1995Assignees: Pola Chemical Industries Inc., Nobuo NakabayashiInventors: Masao Shaku, Sayuri Ohkura, Hideo Kuroda, Ai Kano, Nobuo Nakabayashi