Patents by Inventor Nobuyuki Isoshima

Nobuyuki Isoshima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11953508
    Abstract: An automatic analysis device includes a processing unit 3 which performs the treatment on a specimen before analysis of the specimen, supply equipment which supplies a reagent to a reaction vessel 11 disposed in the processing unit 3, a liquid temperature adjusting unit 1 which adjusts a temperature of the reagent supplied to the reaction vessel 11 by the supply equipment, a control unit 201, and a first temperature detection unit 4 which detects at least one temperature of a temperature of the air within the processing unit 3 and a temperature of the reagent supplied to the reaction vessel 11, in which the liquid temperature adjusting unit 1 and the control unit 201 execute temperature adjustment of the reagent based on a first temperature detected by the first temperature detection unit 4.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: April 9, 2024
    Assignee: Hitachi High-Tech Corporation
    Inventors: Sunao Funakoshi, Takenori Okusa, Nobuyuki Isoshima, Koki Yokoyama
  • Patent number: 11906534
    Abstract: Provided is an automated analyzer comprising a temperature regulator that can be made more compact in size while maintaining high-precision temperature regulation. In a temperature-regulating unit (20) of the automated analyzer, a first chemical reservoir (1) is constituted by a large-diameter spiral-shaped pipe, and a second chemical reservoir (2) is constituted by a large-diameter chemical reservoir container. The first chemical reservoir (1), which is positioned upstream of the second chemical reservoir (2), has an internal capacity that is set so as to be greater than the volume of a single discharge of each of syringe pumps (29, 30, 31), and the second chemical reservoir (2) also has an internal capacity (volume) that is set so as to be greater than the volume of a single discharge of each of the respective syringe pumps (29, 30, 31).
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: February 20, 2024
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Sunao Funakoshi, Takenori Okusa, Nobuyuki Isoshima, Koki Yokoyama
  • Publication number: 20240033741
    Abstract: The present invention provides a thermal cycler capable of rapidly and efficiently heating and cooling a reaction liquid. The thermal cycler according to the present invention comprises: a temperature control block where a reaction vessel can be installed, a thermoelectric conversion unit capable of heating and cooling, a temperature sensor that measures the temperature of the temperature control block, an insulating substrate that is in contact at one surface with the thermoelectric conversion unit, and a heat radiating unit that is provided on the other surface of the insulating substrate and serves for discharging the heat of the thermoelectric conversion unit to the outside, wherein the temperature control block is heated and cooled by controlling a current or voltage supplied to the thermoelectric conversion unit on the basis of the temperature of the temperature adjustment block measured by the temperature sensor.
    Type: Application
    Filed: December 18, 2020
    Publication date: February 1, 2024
    Applicant: Hitachi High-Tech Corporation
    Inventors: Nobuyuki ISOSHIMA, Tatsuya KOBARI, Masashi SHIBAHARA, Toshiki YAMAGATA, Yoko MAKINO, Wataru SATOH
  • Publication number: 20230294101
    Abstract: The purpose of the present invention is to provide a temperature control device (1) capable of changing the temperature of a temperature regulating block (2) rapidly and with high accuracy. A temperature control device (1) according to the present invention is provided with: the temperature regulating block (2), on which a container (5) accommodating a solution (6) can be placed; and a temperature regulating part (3) that is installed so as to contact the temperature regulating block (2) and that changes the temperature of the solution (6), wherein the temperature regulating block (2) is provided with, on the inside thereof, one or a plurality of hollow parts (7).
    Type: Application
    Filed: September 2, 2020
    Publication date: September 21, 2023
    Inventors: Wataru SATO, Nobuyuki ISOSHIMA, Tatsuya KOBARI, Masashi SHIBAHARA
  • Publication number: 20230266349
    Abstract: To provide a reagent cooler reduced in size as compared with that in the related art by reducing a thickness of a heat insulation material of the reagent cooler, and an automated analyzer including the reagent cooler. In the reagent cooler of the automated analyzer, a vacuum heat insulation material is disposed in a periphery (on a side surface, or/and upper and lower portions) of a cooling jacket of the reagent cooler. Then, an end portion of the vacuum heat insulation material is disposed at a position shifted from upper and lower end portions and a side surface end portion of the cooling jacket and a distance between the end portion of the vacuum heat insulation material and the cooling jacket is taken as much as possible.
    Type: Application
    Filed: February 18, 2021
    Publication date: August 24, 2023
    Inventors: Sunao FUNAKOSHI, Takenori OKUSA, Nobuyuki ISOSHIMA, Koki YOKOYAMA
  • Publication number: 20230102788
    Abstract: Provided is an automatic analysis device that can suppress the occurrence of condensation in a reagent cool box and can immediately drain the condensation water generated by introducing outside air. In an automatic analysis device including a reagent cool box that stores a plurality of reagent vessels while keeping the reagent vessels cool, the reagent cool box includes a drain for discharging the condensation water generated inside the reagent cool box, and an outside air introduction path that guides air outside the reagent cool box to the inside, wherein the outside air introduction path is provided along a bottom surface of the reagent cool box, and an outside air discharge port is formed toward an upper opening unit of the drain.
    Type: Application
    Filed: February 19, 2021
    Publication date: March 30, 2023
    Applicant: HITACHI HIGH-TECH CORPORATION
    Inventors: Koki YOKOYAMA, Takenori OKUSA, Nobuyuki ISOSHIMA
  • Publication number: 20230094934
    Abstract: It is an object of the present invention to provide an electrophoresis device that allows for reducing the temperature variation in the thermostat and that makes it easy to attach/detach the capillary. The electrophoresis device according to an aspect of the present invention includes: a capillary array unit that includes a capillary and a support that supports the capillary; a pump mechanism having one end of the capillary being connected thereto and for delivering a separation medium to the capillary; a detection unit that emits light to a portion of the capillary and performs a measurement on a sample in the capillary; and a thermostat that houses the capillary therein and performs temperature control on the capillary, in which the thermostat includes a heat source and a fan that sends air into the thermostat, and in which the thermostat or the capillary array unit includes a straightening plate.
    Type: Application
    Filed: February 15, 2021
    Publication date: March 30, 2023
    Applicant: HITACHI HIGH-TECH CORPORATION
    Inventors: Katsuhiro Aritome, Takeshi Ooura, Asami Terakado, Nobuyuki Isoshima
  • Patent number: 11402368
    Abstract: A biological sample analyzer using a nanopore, said analyzer comprising: a first chamber that storing a solvent; a baseboard provided with a nanopore through which a biological sample passes; a second chamber which is positioned adjacently to the first chamber via the baseboard and stores the solvent; a first electrode formed in the first chamber; a second electrode formed in the second chamber; a detector detecting the biological sample which has passed through the nanopore; and a stirrer stirring the solvent in the first chamber.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: August 2, 2022
    Assignee: Hitachi High-Tech Corporation
    Inventors: Michiru Fujioka, Nobuyuki Isoshima, Wataru Sato
  • Publication number: 20220214369
    Abstract: Provided is an automatic analysis device capable of adjusting the temperature of a plurality of portions requiring temperature control with less power consumption as a whole.
    Type: Application
    Filed: May 19, 2020
    Publication date: July 7, 2022
    Applicant: HITACHI HIGH-TECH CORPORATION
    Inventors: Sunao FUNAKOSHI, Takenori OKUSA, Nobuyuki ISOSHIMA, Koki YOKOYAMA
  • Patent number: 11300488
    Abstract: Temperature uniformity of a reaction liquid in a plurality of reaction containers of an automatic analysis device is maintained by a heat block. A strip-shaped heater heats the heat block, and is wound and attached on an outer circumference of the heat block so that both end regions of the strip-shaped heater are adjacent to each other. The strip-shaped heater includes a heat generating resistor that is heated by applying an electric current, an insulating film sandwiching the heat generating resistor, and first and second electrical feed lines that are attached to both end portions of the heat generating resistor and supply power to the heat generating resistor. The width of the heat generating resistor in both end regions of the strip-shaped heater is formed to be narrower than the width of the heat generating resistor in the other region thereof.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: April 12, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Koki Yokoyama, Nobuyuki Isoshima, Takenori Okusa, Shigeyuki Sasaki, Michiharu Watanabe
  • Publication number: 20210382078
    Abstract: An automatic analysis device includes a processing unit 3 which performs the treatment on a specimen before analysis of the specimen, supply equipment which supplies a reagent to a reaction vessel 11 disposed in the processing unit 3, a liquid temperature adjusting unit 1 which adjusts a temperature of the reagent supplied to the reaction vessel 11 by the supply equipment, a control unit 201, and a first temperature detection unit 4 which detects at least one temperature of a temperature of the air within the processing unit 3 and a temperature of the reagent supplied to the reaction vessel 11, in which the liquid temperature adjusting unit 1 and the control unit 201 execute temperature adjustment of the reagent based on a first temperature detected by the first temperature detection unit 4.
    Type: Application
    Filed: October 9, 2019
    Publication date: December 9, 2021
    Inventors: Sunao FUNAKOSHI, Takenori OKUSA, Nobuyuki ISOSHIMA, Koki YOKOYAMA
  • Patent number: 11193099
    Abstract: Provided is a highly reliable temperature adjustment apparatus which uses a temperature adjustment element and quantitatively evaluates the temperature adjustment performance of the temperature adjustment element. The temperature adjustment apparatus is provided with: a temperature adjustment element; one or more temperature detection elements provided near the temperature adjustment element; a calculation unit for calculating the output of the temperature detection element; and a display unit for displaying at least one of a time calculated by the calculation unit as a time at which the temperature adjustment performance of the temperature adjustment is predicted to be below a desired level, the number of operations and the time of current conduction or a warning based on the result of calculation.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: December 7, 2021
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Wataru Sato, Nobuyuki Isoshima, Kohshi Maeda, Daisuke Morishima
  • Publication number: 20210302457
    Abstract: Provided is an automated analyzer comprising a temperature regulator that can be made more compact in size while maintaining high-precision temperature regulation. In a temperature-regulating unit (20) of the automated analyzer, a first chemical reservoir (1) is constituted by a large-diameter spiral-shaped pipe, and a second chemical reservoir (2) is constituted by a large-diameter chemical reservoir container. The first chemical reservoir (1), which is positioned upstream of the second chemical reservoir (2), has an internal capacity that is set so as to be greater than the volume of a single discharge of each of syringe pumps (29, 30, 31), and the second chemical reservoir (2) also has an internal capacity (volume) that is set so as to be greater than the volume of a single discharge of each of the respective syringe pumps (29, 30, 31).
    Type: Application
    Filed: June 24, 2019
    Publication date: September 30, 2021
    Inventors: Sunao FUNAKOSHI, Takenori OKUSA, Nobuyuki ISOSHIMA, Koki YOKOYAMA
  • Publication number: 20190376883
    Abstract: Temperature uniformity of a reaction liquid in a plurality of reaction containers of an automatic analysis device is maintained by a heat block. A strip-shaped heater heats the heat block, and is wound and attached on an outer circumference of the heat block so that both end regions of the strip-shaped heater are adjacent to each other. The strip-shaped heater includes a heat generating resistor that is heated by applying an electric current, an insulating film sandwiching the heat generating resistor, and first and second electrical feed lines that are attached to both end portions of the heat generating resistor and supply power to the heat generating resistor. The width of the heat generating resistor in both end regions of the strip-shaped heater is formed to be narrower than the width of the heat generating resistor in the other region thereof.
    Type: Application
    Filed: January 18, 2018
    Publication date: December 12, 2019
    Inventors: Koki YOKOYAMA, Nobuyuki ISOSHIMA, Takenori OKUSA, Shigeyuki SASAKI, Michiharu WATANABE
  • Publication number: 20190308194
    Abstract: Provided is an automatic analyzer having a rapid start-up of a heat block while precisely controlling a temperature of a reaction solution. In the automatic analyzer equipped with a reaction-vessel-holding part, a heat block having a heat source to heat the reaction vessel, and a cooling system having a low temperature region and a high temperature region, an outer peripheral part of or below the reaction-vessel-holding part is defined as a heat transfer space, there are provided a heat transfer passage connecting the heat transfer space and the high temperature region, a heat medium circulating through the high temperature region, the heat transfer passage, and the heat transfer space, and a flow rate control means configured to control a flow rate of the heat medium in the heat transfer passage, and a temperature detection means is provided on a downstream side of the high temperature region.
    Type: Application
    Filed: June 20, 2017
    Publication date: October 10, 2019
    Inventors: Michiharu WATANABE, Shigeyuki SASAKI, Takenori OKUSA, Nobuyuki ISOSHIMA
  • Publication number: 20180313813
    Abstract: A biological sample analyzer using a nanopore, said analyzer comprising: a first chamber that storing a solvent; a baseboard provided with a nanopore through which a biological sample passes; a second chamber which is positioned adjacently to the first chamber via the baseboard and stores the solvent; a first electrode formed in the first chamber; a second electrode formed in the second chamber; a detector detecting the biological sample which has passed through the nanopore; and a stirrer stirring the solvent in the first chamber.
    Type: Application
    Filed: November 24, 2015
    Publication date: November 1, 2018
    Inventors: Michiru FUJIOKA, Nobuyuki ISOSHIMA, Wataru SATO
  • Publication number: 20180245031
    Abstract: Provided is a highly reliable temperature adjustment apparatus which uses a temperature adjustment element and quantitatively evaluates the temperature adjustment performance of the temperature adjustment element. The temperature adjustment apparatus is provided with: a temperature adjustment element; one or more temperature detection elements provided near the temperature adjustment element; a calculation unit for calculating the output of the temperature detection element; and a display unit for displaying at least one of a time calculated by the calculation unit as a time at which the temperature adjustment performance of the temperature adjustment is predicted to be below a desired level, the number of operations and the time of current conduction or a warning based on the result of calculation.
    Type: Application
    Filed: July 27, 2016
    Publication date: August 30, 2018
    Inventors: Wataru SATO, Nobuyuki ISOSHIMA, Kohshi MAEDA, Daisuke MORISHIMA
  • Patent number: 8854932
    Abstract: There is provided a head-gimbal-assembly for use in heat-assist magnetic recording, excellent in the heat-release characteristic of a laser diode, by inhibiting effects of deterioration in lateral balance, and wind turbulence without adversely affecting efforts to lower a profile of a magnetic disk unit. For this purpose, a sub-mount with a laser diode attached thereto is mounted on either of the right and left lateral faces of a head slider. Further, of two lengths of lead wires for power supply to the laser diode, one length of the lead wire is routed to a lateral face of the head-slider, on the opposite side of a lateral face with the sub-mount attached thereto, after circling around the outer periphery of a head-slider electrode, formed on the gas-outlet side of the head slider.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: October 7, 2014
    Assignee: Hitachi, Ltd.
    Inventor: Nobuyuki Isoshima
  • Publication number: 20140050056
    Abstract: There is provided a head-gimbal-assembly for use in heat-assist magnetic recording, excellent in the heat-release characteristic of a laser diode, by inhibiting effects of deterioration in lateral balance, and wind turbulence without adversely affecting efforts to lower a profile of a magnetic disk unit. For this purpose, a sub-mount with a laser diode attached thereto is mounted on either of the right and left lateral faces of a head slider. Further, of two lengths of lead wires for power supply to the laser diode, one length of the lead wire is routed to a lateral face of the head-slider, on the opposite side of a lateral face with the sub-mount attached thereto, after circling around the outer periphery of a head-slider electrode, formed on the gas-outlet side of the head slider.
    Type: Application
    Filed: April 25, 2011
    Publication date: February 20, 2014
    Applicant: HITACHI, LTD.
    Inventor: Nobuyuki Isoshima
  • Publication number: 20130222947
    Abstract: A removable cover assembly for a data storage device comprises a first cover coupled with a casing base of a data storage device via a plurality of screws. A second cover is disposed upon a rib of the casing base and is coupled with the rib. The second cover is configured with a groove which delineates a perimeter separating an interior region of the second cover from an exterior region of the second cover. A space between the first cover and the casing base is filled with a low-density gas. The groove defines the region in the second cover in which separation of the interior region from the exterior region is to occur to expose the screws.
    Type: Application
    Filed: February 29, 2012
    Publication date: August 29, 2013
    Inventors: Taisuke Sugii, Masaru Muranishi, Nobuyuki Isoshima, Takehiko Eguchi