Patents by Inventor Nobuyuki NUKINA

Nobuyuki NUKINA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein cross-linking inhibitor
    Patent number: 8853424
    Abstract: The present invention provides a protein cross-linking inhibitor containing a compound represented by any of the following formulas (1)-(13), or a pharmaceutically acceptable salt thereof: R3—[—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(1) R3—[—X—B(ZR1)—Y—]n—R4,??(2) R3—[—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(3) R3—[—X—B(ZR1)—]n—R4,??(4) R3—[—B(ZR2)—W—]n—R4,??(5) R3—X—B(ZR1)-T[B(ZR2)—W—R4]2,??(6) R3—B(OH)2,??(7) R3—B(ZR1)—X—B(ZR2)—R4,??(8) R3—B(R1)—O—B(R2)—R4,??(9) R3—[—X—B(ZR1)—Y—B(ZR2)—]n—R4,??(10) R3—[—X—B(ZR1)—Y—B(ZR2)—W-Q-]n—R4,??(11) R3—[—P—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(12) [R3—X—B(ZR1)—Y]2B(ZR2),??(13) wherein each symbol is as defined in the DESCRIPTION.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: October 7, 2014
    Assignee: Japan Science and Technology Agency
    Inventors: Katsuhiko Mikoshiba, Nobuyuki Nukina, Shoichiro Ozaki, Kouzo Hamada, Jun-Ichi Goto, Akinobu Suzuki, Etsuko Ebisui, Akiko Terauchi
  • PROTEIN CROSS-LINKING INHIBITOR
    Publication number: 20110212919
    Abstract: The present invention provides a protein cross-linking inhibitor containing a compound represented by any of the following formulas (1)-(13), or a pharmaceutically acceptable salt thereof: R3—[—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(1) R3—[—X—B(ZR1)—Y—]n—R4,??(2) R3—[—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(3) R3—[—X—B(ZR1)—]n—R4,??(4) R3—[—B(ZR2)—W—]n—R4,??(5) R3—X—B(ZR1)-T[B(ZR2)—W—R4]2,??(6) R3—B(OH)2,??(7) R3—B(ZR1)—X—B(ZR2)—R4,??(8) R3—B(R1)—O—B(R2)—R4,??(9) R3—[—X—B(ZR1)—Y—B(ZR2)—]n—R4,??(10) R3—[—X—B(ZR1)—Y—B(ZR2)—W-Q-]n—R4,??(11) R3—[—P—X—B(ZR1)—Y—B(ZR2)—W—]n—R4,??(12) [R3—X—B(ZR1)—Y]2B(ZR2),??(13) wherein each symbol is as defined in the DESCRIPTION.
    Type: Application
    Filed: August 11, 2009
    Publication date: September 1, 2011
    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Katsuhiko Mikoshiba, Nobuyuki Nukina, Shoichiro Ozaki, Kouzo Hamada, Jun-Ichi Goto, Akinobu Suzuki, Etsuko Ebisui, Akiko Terauchi
  • METHOD OF DEGRADING PROTEIN BY CHAPERONE-MEDIATED AUTOPHAGY
    Publication number: 20100016221
    Abstract: The present invention provides a method of degrading a target protein in a subject comprising administrating to the subject an effective amount of any of: (a) a peptide comprising an HSC70-binding moiety and a target protein-binding moiety; and/or (b) a polynucleotide encoding the peptide of (a). The present invention further provides an isolated peptide comprising an HSC70-binding moiety and a target protein-binding moiety, an isolated polynucleotide encoding said peptide, and an expression vector comprising said polynucleotide.
    Type: Application
    Filed: July 17, 2008
    Publication date: January 21, 2010
    Applicant: RIKEN
    Inventors: Nobuyuki NUKINA, Peter BAUER
  • AGENT FOR THE PROPHYLAXIS OR TREATMENT OF NEURODEGENERATIVE DISEASE
    Publication number: 20080242680
    Abstract: The present invention provides a novel and useful agent for the prophylaxis or treatment of neurodegenerative diseases. Particularly, the present invention provides an agent for the prophylaxis or treatment of a neurodegenerative disease, which contains a compound represented by the following formula (I) as an active ingredient: wherein R1, R2, R3 are each independently an optionally substituted amino group, and R4 is halogen.
    Type: Application
    Filed: March 6, 2008
    Publication date: October 2, 2008
    Applicant: RIKEN
    Inventors: Nobuyuki NUKINA, Hon-kit WONG