Patents by Inventor Noel G. Harvey
Noel G. Harvey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10322272Abstract: Methods and devices for administration of substances into at least two compartments of skin for systemic absorption and improved pharmacokinetics, based on biphasic or bimodel kinetic profiling.Type: GrantFiled: November 2, 2015Date of Patent: June 18, 2019Assignee: Becton, Dickinson and CompanyInventors: Ronald J. Pettis, Noel G. Harvey, Barry Ginsberg
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Patent number: 9717451Abstract: A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.Type: GrantFiled: April 10, 2012Date of Patent: August 1, 2017Assignee: Becton, Dickinson and CompanyInventors: James Down, Noel G. Harvey, Frank E. Martin, Ronald J. Pettis, Alexander G. Lastovich
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Publication number: 20160207253Abstract: A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.Type: ApplicationFiled: April 10, 2012Publication date: July 21, 2016Inventors: James Down, Noel G. Harvey, Frank E. Martin, Ronald J. Pettis, Alexander G. Lastovich
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Publication number: 20160051807Abstract: Methods and devices for administration of substances into at least two compartments of skin for systemic absorption and improved pharmacokinetics, based on biphasic or bimodel kinetic profiling.Type: ApplicationFiled: November 2, 2015Publication date: February 25, 2016Inventors: Ronald J. Pettis, Noel G. Harvey, Barry Ginsberg
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Patent number: 9242052Abstract: A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between 0.3 mm and 2 mm such that the delivery of the substance occurs at a depth between 0.3 mm and 2 mm.Type: GrantFiled: March 17, 2014Date of Patent: January 26, 2016Assignee: Becton, Dickinson and CompanyInventors: Ronald J Pettis, Noel G Harvey, James A Down
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Patent number: 9005182Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.Type: GrantFiled: April 19, 2013Date of Patent: April 14, 2015Assignee: Becton, Dickinson and CompanyInventors: Ronald J. Pettis, James A. Down, Noel G. Harvey
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Patent number: 8998877Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.Type: GrantFiled: April 19, 2013Date of Patent: April 7, 2015Assignee: Becton, Dickinson and CompanyInventors: Ronald J. Pettis, James A. Down, Noel G. Harvey
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Patent number: 8986280Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.Type: GrantFiled: April 19, 2013Date of Patent: March 24, 2015Assignee: Becton, Dickinson and CompanyInventors: Ronald J. Pettis, James A. Down, Noel G. Harvey
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Publication number: 20140200547Abstract: A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between 0.3 mm and 2 mm such that the delivery of the substance occurs at a depth between 0.3 mm and 2 mm.Type: ApplicationFiled: March 17, 2014Publication date: July 17, 2014Applicant: Becton Dickinson and CompanyInventors: Ronald J. Pettis, Noel G. Harvey, James A. Down
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Patent number: 8708994Abstract: A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between 0.3 mm and 2 mm such that the delivery of the substance occurs at a depth between 0.3 mm and 2 mm.Type: GrantFiled: March 28, 2011Date of Patent: April 29, 2014Assignee: Becton, Dickinson and CompanyInventors: Ronald J. Pettis, Noel G. Harvey, James A. Down
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Publication number: 20130263997Abstract: A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.Type: ApplicationFiled: April 10, 2012Publication date: October 10, 2013Inventors: James Down, Noel G. Harvey, Frank E. Martin, Ronald J. Pettis, Alexander G. Lastovich
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Publication number: 20130245601Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.Type: ApplicationFiled: April 19, 2013Publication date: September 19, 2013Applicant: Becton, Dickinson and CompanyInventors: Ronald J. Pettis, James A. Down, Noel G. Harvey
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Publication number: 20130237961Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to delver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.Type: ApplicationFiled: April 19, 2013Publication date: September 12, 2013Applicant: Becton, Dickinson and CompanyInventors: Ronald J. Pettis, James A. Down, Noel G. Harvey
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Publication number: 20130237960Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.Type: ApplicationFiled: April 19, 2013Publication date: September 12, 2013Applicant: Becton, Dickinson and CompanyInventors: Ronald J. Pettis, James A. Down, Noel G. Harvey
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Patent number: 8465468Abstract: The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient.Type: GrantFiled: June 29, 2000Date of Patent: June 18, 2013Assignee: Becton, Dickinson and CompanyInventors: Ronald J. Pettis, James A. Down, Noel G. Harvey
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Patent number: 8172815Abstract: A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.Type: GrantFiled: May 23, 2003Date of Patent: May 8, 2012Assignee: Becton, Dickinson and CompanyInventors: James Down, Noel G. Harvey, Frank E. Martin, Ronald J. Pettis, Alexander G. Lastovich
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Publication number: 20110190725Abstract: A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between 0.3 mm and 2 mm such that the delivery of the substance occurs at a depth between 0.3 mm and 2 mm.Type: ApplicationFiled: March 28, 2011Publication date: August 4, 2011Inventors: Ronald J. Pettis, Noel G. Harvey, James A. Down
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Publication number: 20080234656Abstract: A method for directly delivering whereby a substance is introduced into an intradermal space within mammalian skin which involves administering the substance through at least one small gauge hollow needle having an outlet with an exposed height between 0 and 1 mm. The outlet is inserted into the skin to a depth of between 0.3 mm and 2 mm such that the delivery of the substance occurs at a depth between 0.3 mm and 2 mm.Type: ApplicationFiled: April 9, 2008Publication date: September 25, 2008Inventors: Ronald J. Pettis, Noel G. Harvey, James A. Down
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Publication number: 20080147042Abstract: Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption.Type: ApplicationFiled: October 31, 2007Publication date: June 19, 2008Inventors: Ronald J. Pettis, Noel G. Harvey, James A. Down
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Publication number: 20080138286Abstract: Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption.Type: ApplicationFiled: October 31, 2007Publication date: June 12, 2008Inventors: Ronald J. Pettis, Noel G. Harvey, James A. Down