Patents by Inventor Noel Nicolaas Maria Elisabeth Van Peij
Noel Nicolaas Maria Elisabeth Van Peij has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220389458Abstract: The invention relates to an improved method for the transfection of fungal cells.Type: ApplicationFiled: November 2, 2020Publication date: December 8, 2022Inventors: Maarten Dirk VERHOEVEN, Johannes Andries ROUBOS, Noel Nicolaas Maria Elisabeth VAN PEIJ
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Patent number: 10100344Abstract: The present invention relates to a mutant microbial host cell which is deficient in the production of the AgsE protein or in the production of an homologous thereof if compared with a parent microbial host cell which has not been modified and measured under the same conditions. It has been surprisingly found that when the mutant microbial host cell according to the invention is used in a method to produce a compound of interest, for example an enzyme, an improved yield of said compound is obtained if compared to a method in which a parent host cell which has not been modified is used when measured under the same conditions.Type: GrantFiled: January 27, 2017Date of Patent: October 16, 2018Assignee: DSM IP ASSETS B.V.Inventors: Noël Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Peter Jozef Ida Van De Vondervoort
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Patent number: 10035986Abstract: The present invention relates to a mutant microbial host cell which is deficient in the production of the AgsE protein or in the production of an homologous thereof if compared with a parent microbial host cell which has not been modified and measured under the same conditions. It has been surprisingly found that when the mutant microbial host cell according to the invention is used in a method to produce a compound of interest, for example an enzyme, an improved yield of said compound is obtained if compared to a method in which a parent host cell which has not been modified is used when measured under the same conditions.Type: GrantFiled: July 19, 2013Date of Patent: July 31, 2018Assignee: DSM IP ASSETS B.V.Inventors: Noël Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Peter Jozef Ida Van De Vondervoort
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Patent number: 9745563Abstract: The present invention relates to a mutant microbial host cell which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide having ?-amylase activity AmyC or an homologous thereof. It has been surprisingly found that when the mutant microbial host cell according to the invention is used in a method to produce a compound of interest, for example an enzyme, an improved purity of the product is obtained.Type: GrantFiled: July 19, 2013Date of Patent: August 29, 2017Assignee: DSM IP ASSETS B.V.Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Peter Jozef Ida Van De Vondervoort
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Publication number: 20170175158Abstract: The present invention relates to a mutant microbial host cell which is deficient in the production of the AgsE protein or in the production of an homologous thereof if compared with a parent microbial host cell which has not been modified and measured under the same conditions. It has been surprisingly found that when the mutant microbial host cell according to the invention is used in a method to produce a compound of interest, for example an enzyme, an improved yield of said compound is obtained if compared to a method in which a parent host cell which has not been modified is used when measured under the same conditions.Type: ApplicationFiled: January 27, 2017Publication date: June 22, 2017Inventors: Noël Nicolaas Maria Elisabeth VAN PEIJ, Martina BEISHUIZEN, Peter Jozef Ida VAN DE VONDERVOORT
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Patent number: 9657309Abstract: The present invention relates to a method for carrying out recombination at a target locus.Type: GrantFiled: March 12, 2013Date of Patent: May 23, 2017Assignee: DSM IP ASSETS B.V.Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Yvonne Johannes Odilia Arendsen
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Patent number: 9322045Abstract: The present invention relates to a recombinant host cell for the production of a compound of interest. The invention further relates to a method for the production of such host cell. The invention further relates to the production of a compound of interest. The invention further relates to isolated polynucleotides and vectors and host cells comprising said polynucleotides.Type: GrantFiled: April 10, 2014Date of Patent: April 26, 2016Assignee: DSM IP ASSETS B.V.Inventors: Noël Nicolaas Maria Elisabeth Van Peij, Herman Jan Pel, Thibaut José Wenzel, Adriana Marina Riemens, Ilse De Lange
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Patent number: 9181573Abstract: The present invention relates to a method for improving protein yield. The method comprises modifying the value of a set of relevant protein features to fall within an optimal range or to become more close to an optimal value for one or more protein features in the eukaryotic host.Type: GrantFiled: March 8, 2010Date of Patent: November 10, 2015Assignee: DSM IP ASSETS B.V.Inventors: Jan Metske Van Der Laan, Liang Wu, Johannes Andries Roubos, Lucie Parenicova, Alrik Pieter Los, Noel Nicolaas Maria Elisabeth Van Peij, Jan Herman Pel
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Publication number: 20150191705Abstract: The present invention relates to a mutant microbial host cell which is deficient in the production of the AgsE protein or in the production of an homologous thereof if compared with a parent microbial host cell which has not been modified and measured under the same conditions. It has been surprisingly found that when the mutant microbial host cell according to the invention is used in a method to produce a compound of interest, for example an enzyme, an improved yield of said compound is obtained if compared to a method in which a parent host cell which has not been modified is used when measured under the same conditions.Type: ApplicationFiled: July 19, 2013Publication date: July 9, 2015Inventors: Noël Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Peter Jozef Ida Van De Vondervoort
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Publication number: 20150166970Abstract: The present invention relates to a mutant microbial host cell which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide having ?-amylase activity AmyC or an homologous thereof. It has been surprisingly found that when the mutant microbial host cell according to the invention is used in a method to produce a compound of interest, for example an enzyme, an improved purity of the product is obtained.Type: ApplicationFiled: July 19, 2013Publication date: June 18, 2015Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Peter Jozef Ida Van De Vondervoort
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Publication number: 20150050739Abstract: The present invention relates to a method for carrying out recombination at a target locus.Type: ApplicationFiled: March 12, 2013Publication date: February 19, 2015Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Yvonne Johannes Odilia Arendsen
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Patent number: 8945898Abstract: The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest.Type: GrantFiled: July 1, 2011Date of Patent: February 3, 2015Assignee: DSM IP Assets B.V.Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Marcus Hans, Martina Beishuizen, Dick Schipper, Robertus Antonius Mijndert Van Der Hoeven, Olaf Leonardus Schouten
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Publication number: 20140377800Abstract: The present invention relates to methods of optimization of a protein coding sequences for expression in a given host cell. The methods apply genetic algorithms to optimise single codon fitness and/or codon pair fitness sequences coding for a predetermined amino acid sequence. In the algorithm generation of new sequence variants and subsequent selection of fitter variants is reiterated until the variant coding sequences reach a minimum value for single codon fitness and/or codon pair fitness. The invention also relates to a computer comprising a processor and memory, the processor being arranged to read from and write into the memory, the memory comprising data and instructions arranged to provide the processor with the capacity to perform the genetic algorithms for optimisation of single codon fitness and/or codon pair fitness.Type: ApplicationFiled: May 20, 2014Publication date: December 25, 2014Inventors: Johannes Andries ROUBOS, Noel Nicolaas Maria Elisabeth VAN PEIJ
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Publication number: 20140248662Abstract: The present invention relates to a recombinant host cell for the production of a compound of interest. The invention further relates to a method for the production of such host cell. The invention further relates to the production of a compound of interest. The invention further relates to isolated polynucleotides and vectors and host cells comprising said polynucleotides.Type: ApplicationFiled: April 10, 2014Publication date: September 4, 2014Applicant: DSM IP ASSETS B.V.Inventors: Noël Nicolaas Maria Elisabeth VAN PEIJ, Herman Jan PEL, Thibaut Jose WENZEL, Adriana Marina RIEMENS, Ilse DE LANGE
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Patent number: 8812247Abstract: The present invention relates to methods of optimization of a protein coding sequences for expression in a given host cell. The methods apply genetic algorithms to optimise single codon fitness and/or codon pair fitness sequences coding for a predetermined amino acid sequence. In the algorithm generation of new sequence variants and subsequent selection of fitter variants is reiterated until the variant coding sequences reach a minimum value for single codon fitness and/or codon pair fitness. The invention also relates to a computer comprising a processor and memory, the processor being arranged to read from and write into the memory, the memory comprising data and instructions arranged to provide the processor with the capacity to perform the genetic algorithms for optimization of single codon fitness and/or codon pair fitness.Type: GrantFiled: June 15, 2007Date of Patent: August 19, 2014Assignee: DSM IP Assets B.V.Inventors: Johannes Andries Roubos, Noël Nicolaas Maria Elisabeth Van Peij
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Patent number: 8642290Abstract: The present invention relates to functional cDNA and genomic sequences encoding PrtT proteins, which are transcriptional activity on a protease promoter, to PrtT proteins and their uses. The invention further relates to two distinct types of filamentous fungal cells. Filamentous fungal cells are transformed to over-express these PrtT proteins: this type of filamentous fungus will be highly suited as protease producer. Alternatively, the endogenous prtT genes of filamentous fungal cells are inactivated: this type of filamentious fungus is highly suited for the production of any polypeptide native or not which is highly sensitive for protease degradation. The PrtT proteins of the invention provide means for identification of functional homologues in other species.Type: GrantFiled: July 2, 2010Date of Patent: February 4, 2014Assignee: DSM IP Assets B.V.Inventors: Noël Nicolaas Maria Elisabeth van Peij, Lucie Parenicova
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Patent number: 8637280Abstract: The present invention relates to newly identified genes that encode proteins that are involved in the (bio)synthesis of citric acid. The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of citric acid from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for production of citric acid.Type: GrantFiled: December 1, 2006Date of Patent: January 28, 2014Assignee: Adcuram Nutrition Holding GmbHInventors: Hugo Marc Karel Bauweleers, Dominique Robert Groeseneken, Noël Nicolaas Maria Elisabeth Van Peij
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Publication number: 20130189733Abstract: The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype.Type: ApplicationFiled: January 25, 2013Publication date: July 25, 2013Applicant: DSM IP ASSETS B.V.Inventors: CORNELIS MARIA JACOBUS SAGT, CORNELIS THEODORUS VERRIPS, WALRAVEN HENRY MULLER, NOEL NICOLAAS MARIA ELISABETH VAN PEIJ
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Publication number: 20130144034Abstract: The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest.Type: ApplicationFiled: July 1, 2011Publication date: June 6, 2013Applicant: DSM IP ASSETS B.V.Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Marcus Hans, Martina Beishuizen, Dick Schipper, Robertus Antonius Mijndert Van Der Hoeven, Olaf Leonardus Schouten
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Patent number: 8389269Abstract: The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype.Type: GrantFiled: October 31, 2007Date of Patent: March 5, 2013Assignee: DSM IP Assets B.V.Inventors: Cornelis Maria Jacobus Sagt, Cornelis Theodorus Verrips, Walraven Henry Muller, Noël Nicolaas Maria Elisabeth Van Peij