Patents by Inventor Noriko Monden
Noriko Monden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10577393Abstract: A porous hollow fiber membrane is provided for the treatment of a protein-containing liquid, which can effectively separate and remove a substance such as a small diameter virus, and which can allow effective permeation of a useful substance to be recovered such as protein in high concentration. The porous hollow fiber membrane has an asymmetric structure having a dense layer in an outer layer only and contains a hydrophobic polymer and a first hydrophilic polymer, the surface and the porous part of the hollow fiber membrane are coated with a second hydrophilic polymer, the hydrophobic polymer is a polysulfone-type polymer, the first hydrophilic polymer is a copolymer of vinylpyrrolidone with vinyl acetate, and the second hydrophilic polymer is a polysaccharide or a polysaccharide derivative. The porous hollow fiber membrane is obtained by co-dissolving the hydrophobic polymer and the first hydrophilic polymer and then the second hydrophilic polymer is coated.Type: GrantFiled: October 23, 2013Date of Patent: March 3, 2020Assignee: TOYOBO CO., LTD.Inventors: Satoru Ashitaka, Toru Uenishi, Noriko Monden, Noriaki Kato
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Patent number: 10137234Abstract: The invention provides a method for sterilizing a blood purifier, as well as a blood purifier package. The method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and is highly reliable in safety when employed for hemocatharsis therapy. The method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.Type: GrantFiled: May 27, 2015Date of Patent: November 27, 2018Assignee: NIPRO CORPORATIONInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 9987408Abstract: Objects of the invention are to provide a blood purifier package which shows a less increase in the amounts of extracts from the materials of its blood purifier, particularly of its selective permeable separation membranes, attributed to the deterioration of the same materials with time after exposure to a radioactive ray or an electron ray, and which is therefore highly reliable in safety in use for hemocatharsis, and to provide a process for manufacturing the same. The present invention relates to a blood purifier package obtained by packing a blood purifier which comprises selectively permeable separation membranes as a main component, and this blood purifier package is characterized in that the blood purifier is packed and sealed together with an oxygen scavenger in a packaging material capable of shutting out an external air and a water vapor, under a condition of a relative humidity of above 40% RH at 25° C.Type: GrantFiled: May 27, 2015Date of Patent: June 5, 2018Assignee: NIPRO CORPORATIONInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 9987409Abstract: The invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis. The blood purifier comprises selectively permeable separation membranes as a main component and is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.Type: GrantFiled: May 27, 2015Date of Patent: June 5, 2018Assignee: NIPRO CORPORATIONInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 9492794Abstract: An object of the present invention is to provide a porous hollow fiber membrane for the treatment of a protein-containing liquid where the substances to be removed such as small-sized virus contained in a solution can be efficiently separated and removed and, at the same time, useful substances to be recovered such as protein can be efficiently permeated and the decrease in the permeation characteristics thereof with elapse of time is small. The porous hollow fiber membrane for the treatment of a protein-containing liquid of the present invention is characterized in that the membrane comprises a hydrophobic polymer and a hydrophilic polymer, its permeability for pure water is 10 to 300 L/(h·m2·bar) and, when a 0.5% immunoglobulin solution is subjected to filtration at a constant pressure of 1.0 bar for 60 minutes in dead-end filtration mode, its filtration time and accumulated amount of recovered filtrate are substantially in a linear relation.Type: GrantFiled: March 8, 2011Date of Patent: November 15, 2016Assignee: TOYOBO BOSEKI KABUSHIKI KAISHAInventors: Hideyuki Yokota, Toru Uenishi, Hirofumi Ogawa, Satoru Ashitaka, Noriko Monden
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Publication number: 20150320921Abstract: The invention provides a method for sterilizing a blood purifier, as well as a blood purifier package. The method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and is highly reliable in safety when employed for hemocatharsis therapy. The method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.Type: ApplicationFiled: May 27, 2015Publication date: November 12, 2015Applicant: NIPRO CORPORATIONInventors: Takashi SUNOHARA, Yuuki HATAKEYAMA, Noriko MONDEN, Toshiaki MASUDA, Noriaki KATO, Kimihiro MABUCHI
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Publication number: 20150258264Abstract: The invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis. The blood purifier comprises selectively permeable separation membranes as a main component and is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.Type: ApplicationFiled: May 27, 2015Publication date: September 17, 2015Applicant: NIPRO CORPORATIONInventors: Kimihiro MABUCHI, Noriko MONDEN, Noriaki KATO, Yuuki HATAKEYAMA, Takashi SUNOHARA, Toshiaki MASUDA
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Publication number: 20150258265Abstract: Objects of the invention are to provide a blood purifier package which shows a less increase in the amounts of extracts from the materials of its blood purifier, particularly of its selective permeable separation membranes, attributed to the deterioration of the same materials with time after exposure to a radioactive ray or an electron ray, and which is therefore highly reliable in safety in use for hemocatharsis, and to provide a process for manufacturing the same. The present invention relates to a blood purifier package obtained by packing a blood purifier which comprises selectively permeable separation membranes as a main component, and this blood purifier package is characterized in that the blood purifier is packed and sealed together with an oxygen scavenger in a packaging material capable of shutting out an external air and a water vapor, under a condition of a relative humidity of above 40% RH at 25° C.Type: ApplicationFiled: May 27, 2015Publication date: September 17, 2015Applicant: NIPRO CORPORATIONInventors: Kimihiro MABUCHI, Noriko MONDEN, Noriaki KATO, Yuuki HATAKEYAMA, Takashi SUNOHARA, Toshiaki MASUDA
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Publication number: 20150232506Abstract: A porous hollow fiber membrane is provided for the treatment of a protein-containing liquid, which can effectively separate and remove a substance such as a small diameter virus, and which can allow effective permeation of a useful substance to be recovered such as protein in high concentration. The porous hollow fiber membrane has an asymmetric structure having a dense layer in an outer layer only and contains a hydrophobic polymer and a first hydrophilic polymer, the surface and the porous part of the hollow fiber membrane are coated with a second hydrophilic polymer, the hydrophobic polymer is a polysulfone-type polymer, the first hydrophilic polymer is a copolymer of vinylpyrrolidone with vinyl acetate, and the second hydrophilic polymer is a polysaccharide or a polysaccharide derivative. The porous hollow fiber membrane is obtained by co-dissolving the hydrophobic polymer and the first hydrophilic polymer and then the second hydrophilic polymer is coated.Type: ApplicationFiled: October 23, 2013Publication date: August 20, 2015Applicant: TOYOBO CO., LTD.Inventors: Satoru Ashitaka, Toru Uenishi, Noriko Monden, Noriaki Kato
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Patent number: 9067178Abstract: Objects of the present invention are to provide a blood purifier package which shows a less increase in the amounts of extracts from the materials of its blood purifier, particularly of its selective permeable separation membranes, attributed to the deterioration of the same materials with time after exposure to a radioactive ray or an electron ray, and which is therefore highly reliable in safety in use for hemocatharsis, and to provide a process for manufacturing the same. The present invention relates to a blood purifier package obtained by packing a blood purifier which comprises selectively permeable separation membranes as a main component, and this blood purifier package is characterized in that the blood purifier is packed and sealed together with an oxygen scavenger in a packaging material capable of shutting out an external air and a water vapor, under a condition of a relative humidity of above 40% RH at 25° C.Type: GrantFiled: December 2, 2005Date of Patent: June 30, 2015Assignee: Nipro CorporationInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 9056280Abstract: The present invention provides a method for sterilizing a blood purifier, which method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and which method is highly reliable in safety when employed for hemocatharsis therapy. The present invention also provides a blood purifier package. The present invention relates to a method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, and this method is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.Type: GrantFiled: October 13, 2005Date of Patent: June 16, 2015Assignee: Nipro CorporationInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 9050410Abstract: The present invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis. The present invention relates to a blood purifier which comprises selectively permeable separation membranes as a main component and which is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.Type: GrantFiled: October 13, 2005Date of Patent: June 9, 2015Assignee: Nipro CorporationInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Publication number: 20120305472Abstract: An object of the present invention is to provide a porous hollow fiber membrane for the treatment of a protein-containing liquid where the substances to be removed such as small-sized virus contained in a solution can be efficiently separated and removed and, at the same time, useful substances to be recovered such as protein can be efficiently permeated and the decrease in the permeation characteristics thereof with elapse of time is small. The porous hollow fiber membrane for the treatment of a protein-containing liquid of the present invention is characterized in that the membrane comprises a hydrophobic polymer and a hydrophilic polymer, its permeability for pure water is 10 to 300 L/(h·m2·bar) and, when a 0.5% immunoglobulin solution is subjected to filtration at a constant pressure of 1.0 bar for 60 minutes in dead-end filtration mode, its filtration time and accumulated amount of recovered filtrate are substantially in a linear relation.Type: ApplicationFiled: March 8, 2011Publication date: December 6, 2012Applicant: TOYO BOSEKI KABUSHIKI KAISHAInventors: Hideyuki Yokota, Toru Uenishi, Hirofumi Ogawa, Satoru Ashitaka, Noriko Monden
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Patent number: 7922007Abstract: The present invention relates to a permselective separation membrane that can be used in blood purifying treatment. More particularly, the present invention relates to a polysulfone-based permselective separation membrane which has well-balanced separation properties, highly stable safety and performance, and also can be smoothly assembled into a module, and a method for producing the same.Type: GrantFiled: March 18, 2005Date of Patent: April 12, 2011Assignee: Toyo Boseki Kabushiki KaishaInventors: Kimihiro Mabuchi, Hideyuki Yokota, Katsuaki Kuze, Noriyuki Tamamura, Makoto Ono, Noriko Monden, Noriaki Kato, Hiroshi Shibano, Katsuhiko Nose
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Patent number: 7837042Abstract: The invention relates to a hollow fiber membrane module comprising polysulfone type selectively permeable hollow fiber membranes which contain a polysulfone-based resin and a hydrophilic polymer as main components, wherein (A) the content of the hydrophilic polymer in the uppermost layer of the inner surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the proximate layer of the inner surface of the membrane, and (B) the content of the hydrophilic polymer in the uppermost layer of the outer surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the uppermost layer of the inner surface of the membrane. The hollow fiber membrane module is exposed to a radioactive ray, on condition that the oxygen concentration of an ambient atmosphere around the hollow fiber membrane is from 0.001 to 0.1%, and that the moisture content of the hollow fiber membrane to the weight thereof is from 0.2 to 7 mass %.Type: GrantFiled: August 9, 2005Date of Patent: November 23, 2010Assignee: Nipro CorporationInventors: Hideyuki Yokota, Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Publication number: 20090272686Abstract: [Purpose] To provide a blood purifier which has high levels of blood compatibility, performance-retaining property when in contact with blood, and safety, and which shows an excellent water permeability-exhibiting rate after a priming treatment and has high reliability in long-term storage.Type: ApplicationFiled: April 3, 2006Publication date: November 5, 2009Applicant: TOYO BOSEKI KABUSHIKI KAISHAInventors: Kimihiro Mabuchi, Hideyuki Yokota, Katsuaki Kuze, Noriko Monden, Noriaki Kato, Makoto Ohno, Mitsuru Suzuki
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Publication number: 20090078641Abstract: Purpose: To provide a blood purifier having a high water permeability, for use in treatment of chronic renal failure, which is not variable in performance during the treatment, independently of a patient's body condition. Solution: The present invention provides a hollow fiber membrane excellent in performance stability, which has an average thickness of from 10 to 50 ?m and an average pore radius of from 150 to 300 ?, and which shows a pure water permeability of 150 to 1,500 mL/m2/hr./mmHg at 37° C., characterized in that the ratio of the overall mass transfer coefficient (Ko?2) of a blood plasma solution of ?2-microgloburin to the overall mass transfer coefficient (Komyo) of an aqueous myoglobin solution (i.e., Ko?2/Komyo) is from 0.7 to 1.0.Type: ApplicationFiled: March 7, 2007Publication date: March 26, 2009Applicant: TOYO BOSEKI KABUSHIKI KAISHAInventors: Noriko Monden, Takahito Sagara, Isamu Yamamoto
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Patent number: 7442302Abstract: The present invention provides a highly water permeable hollow fiber membrane type blood purifier for medical use, which is excellent in safety and module-assembling ease and which has a high water permeability suitable for use in therapy of chronic renal failure. The present invention relates to a highly water-permeable hollow fiber type blood purifier comprising hydrophobic polymer hollow fiber membranes each of which contains a hydrophilic polymer, characterized in that the amount of the hydrophilic polymer eluted from the hollow fiber membrane is 10 ppm or less; in that the ratio of the hydrophilic polymer in the outer surface of the hollow fiber membrane is 25 to 50 mass %; in that the burst pressure of the hollow fiber membrane is 0.5 MPa or higher; and in that the coefficient of water permeability of the blood purifier is 150 ml/m2/hr./mmHg or higher.Type: GrantFiled: August 26, 2004Date of Patent: October 28, 2008Assignee: Toyo Boseki Kabushiki KaishaInventors: Kimihiro Mabuchi, Noriyuki Tamamura, Hidehiko Sakurai, Noriko Monden, Shinya Koyama, Hiroshi Shibano, Katsuaki Kuze, Katsuhiko Nose
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Publication number: 20080142434Abstract: Objects of the present invention are to provide a blood purifier package which shows a less increase in the amounts of extracts from the materials of its blood purifier, particularly of its selective permeable separation membranes, attributed to the deterioration of the same materials with time after exposure to a radioactive ray or an electron ray, and which is therefore highly reliable in safety in use for hemocatharsis, and to provide a process for manufacturing the same. The present invention relates to a blood purifier package obtained by packing a blood purifier which comprises selectively permeable separation membranes as a main component, and this blood purifier package is characterized in that the blood purifier is packed and sealed together with an oxygen scavenger in a packaging material capable of shutting out an external air and a water vapor, under a condition of a relative humidity of above 40% RH at 25° C.Type: ApplicationFiled: December 20, 2005Publication date: June 19, 2008Applicant: Nipro CorporationInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Publication number: 20080087599Abstract: The present invention provides a method for sterilizing a blood purifier, which method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and which method is highly reliable in safety when employed for hemocatharsis therapy. The present invention also provides a blood purifier package. The present invention relates to a method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, and this method is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.Type: ApplicationFiled: October 13, 2005Publication date: April 17, 2008Applicant: NIPRO CORPORATIONInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda