Abstract: Disclosed are a means which enables simple and rapid detection of the presence or absence, and of the degree, of homologous recombination activity in an individual, and a means which is useful for detection and treatment of homologous recombination-restored cancer for which no treatment means is available at present. The nucleic acid construct of the present invention comprises: (1) a promoter region; (2) a mutant gene sequence containing a cleavage site in a gene sequence encoding a protein; and (3) a base sequence composed of a first homologous region and a second homologous region, the base sequence being capable of replacing, by homologous recombination, a partial region in the mutant gene sequence of (2), the partial region containing the cleavage site.

Abstract: Disclosed is means which enables simple and rapid detection of the presence or absence of mismatch repair activity, and which is useful for diagnosis and treatment of mismatch repair-deficient cancers. In an integrated-type nucleic acid construct provided by the present invention, [promoter region], [5?-side region+first homologous region], and [second homologous region+3?-side region] are placed in the same nucleic acid molecule. In a divided-type nucleic acid construct, [promoter region], [5?-side region+first homologous region], and [second homologous region+3?-side region] are placed in two different nucleic acid molecules. The nucleic acid construct of the present invention can be used as a therapeutic agent for mismatch repair-deficient cancer, as a diagnostic agent for mismatch repair-deficient cancer, or as a companion diagnostic agent for predicting an effect of an anticancer drug for mismatch repair-deficient cancer, containing the nucleic acid construct.

Abstract: An information retrieval method for retrieving documents relevant to a user's search inquiry from documents stored in the storage device using an arithmetic operation. The method includes receiving from a user a search query including a plurality of keywords, calculating relevance to a plurality of documents on the basis of the plurality of keywords and the influence set for each keyword, and displaying on the display device documents in the order of relevance. The method also includes displaying on the display device the influence set for each keyword, receiving changes to the displayed influence by the user, and recalculating the relevance on the basis of a change to the influence and displaying on the display device documents in the order of relevance.

Abstract: Provided is a gene targeting vector that enables highly efficient gene targeting. The gene targeting vector has a structure comprising a positive selection marker flanked by a DNA homologous to a 5?-upstream region of a target site and a DNA homologous to a 3?-downstream region of the target site, wherein a splice acceptor site and a DNA sequence allowing for bicistronic expression are added 5?-upstream of the positive selection marker, and another splice acceptor site is also added 5?-upstream of the DNA homologous to the 5?-upstream region of the target site.

Abstract: A system is configured to identify prior search history associated with a user, where the prior search history includes information regarding searches initiated by the user and information regarding search results provided based on the searches. The system is further configured to filter the prior search history to select one of the search results, generate an information item for the search result, and provide the information item to a client, associated with the user, for presentation on a display associated with the client.

Abstract: A method of protecting information in search queries uses a search apparatus with a user interface that is configured for connection to a computer network that comprises a plurality of search engines on a plurality of servers. The method includes receiving a search query comprising a plurality of keywords; dividing the search query into a number of sub-queries, each sub-query comprising at least one of the keywords; and submitting the sub-queries to different search engines.

Abstract: Provided is a gene targeting vector that enables highly efficient gene targeting. The gene targeting vector has a structure comprising a positive selection marker flanked by a DNA homologous to a 5?-upstream region of a target site and a DNA homologous to a 3?-downstream region of the target site, wherein a splice acceptor site and a DNA sequence allowing for bicistronic expression are added 5?-upstream of the positive selection marker, and another splice acceptor site is also added 5?-upstream of the DNA homologous to the 5?-upstream region of the target site.

Abstract: Provided is a gene targeting vector capable of highly efficient gene targeting. A gene targeting vector in which a DNA sequence allowing for bicistronic expression is present 5? upstream of a selection marker. A method for producing a gene targeting vector, comprising linking a DNA fragment homologous to a 5? upstream region of a target site, a selection marker having a DNA sequence allowing for bicistronic expression present 5? upstream thereof, and a DNA fragment homologous to a 3? downstream region of the target site.

Abstract: An information retrieval method for retrieving documents relevant to a user's search inquiry from documents stored in the storage device using an arithmetic operation. The method includes receiving from a user a search query including a plurality of keywords, calculating relevance to a plurality of documents on the basis of the plurality of keywords and the influence set for each keyword, and displaying on the display device documents in the order of relevance. The method also includes displaying on the display device the influence set for each keyword, receiving changes to the displayed influence by the user, and recalculating the relevance on the basis of a change to the influence and displaying on the display device documents in the order of relevance.

Abstract: A system is configured to identify prior search history associated with a user, where the prior search history includes information regarding searches initiated by the user and information regarding search results provided based on the searches. The system is further configured to filter the prior search history to select one of the search results, generate an information item for the search result, and provide the information item to a client, associated with the user, for presentation on a display associated with the client.

Abstract: In a search support server, a related word extraction unit generates frequency information and co-occurrence information of keywords, a graph generation unit generates coordinate information of a spring graph including the keywords as nodes, on the basis of the co-occurrence information, a cluster generation unit groups the nodes into clusters and thereby generates cluster definition information, and a display information generation unit generates display information of the spring graph. In addition, an operation determination unit determines which operation is performed on the spring graph. Then, when a level change is instructed, the display information generation unit generates display information of the spring graph after the level is changed. When a node change is instructed, a cluster re-generation unit changes the cluster definition information and the frequency information.

Abstract: A method of protecting information in search queries uses a search apparatus with a user interface that is configured for connection to a computer network that comprises a plurality of search engines on a plurality of servers.

Abstract: In a search support server, a related word extraction unit generates frequency information and co-occurrence information of keywords, a graph generation unit generates coordinate information of a spring graph including the keywords as nodes, on the basis of the co-occurrence information, a cluster generation unit groups the nodes into clusters and thereby generates cluster definition information, and a display information generation unit generates display information of the spring graph. In addition, an operation determination unit determines which operation is performed on the spring graph. Then, when a level change is instructed, the display information generation unit generates display information of the spring graph after the level is changed. When a node change is instructed, a cluster re-generation unit changes the cluster definition information and the frequency information.

Abstract: A system to convey bobbins between a first overhead rail 4 looping along fine spinning frames 1A to 1M and a second overhead rail 6 connected to roving frames 2A and 2B. The first overhead rail 4 is constructed as a single loop arranged all along the fine spinning frame, while the second overhead rail 6 is constructed as a single loop arranged around the roving frames 2A and 2B. The first and second overhead rails 4 and 6 are connected by a branched rail 7 for returning a bobbin carriage 10 with empty bobbins 12 and by a branched rail 8 for supplying a bobbin carriage 10 with full bobbins 11.