Patents by Inventor Noriyuki KASAGI
Noriyuki KASAGI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240124389Abstract: An object of present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles and pharmaceutical composition using the compound or a salt thereof, which can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided. In the formula, each symbol has a meaning defined in the present specification.Type: ApplicationFiled: October 26, 2023Publication date: April 18, 2024Applicant: FUJIFILM CorporationInventors: Shintaro TANABE, Tatsuya NITABARU, Mashiko YAMAMOTO, Hirofumi FUKUNAGA, Naoto NAKAMURA, Noriyuki KASAGI, Taisuke ENDO, Keiko SUZUKI
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Publication number: 20230210993Abstract: An object of the present invention is to provide a lipid composition capable of achieving excellent nucleic acid delivery. According to the present invention, there is provided a lipid composition containing a lipid represented by Formula (1) or a salt thereof, a nucleic acid, at least one non-cationic lipid, and a lipid represented by R51-L-(OCH2CH2)n—O-R52 (in the formula, R51 represents a hydrocarbon group having 6 to 30 carbon atoms, L represents —CO— or a single bond, R52 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and n represents an integer of 10 to 150). In the formula, each symbol means the definition described in the description.Type: ApplicationFiled: March 13, 2023Publication date: July 6, 2023Applicant: FUJIFILM CorporationInventors: Naoki YAMADA, Shun Kaneumi, Keiko Suzuki, Noriyuki Kasagi, Naoto Nakamura
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Publication number: 20220370352Abstract: An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.Type: ApplicationFiled: August 5, 2022Publication date: November 24, 2022Applicant: FUJIFILM CorporationInventors: Noriyuki Kasagi, Naoki Yamada, Mikinaga Mori, Takayuki Kato, Takayuki Kobayashi
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Patent number: 11446247Abstract: An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.Type: GrantFiled: October 26, 2020Date of Patent: September 20, 2022Assignee: FUJIFILM CorporationInventors: Noriyuki Kasagi, Naoki Yamada, Mikinaga Mori, Takayuki Kato, Takayuki Kobayashi
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Patent number: 11413244Abstract: An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.Type: GrantFiled: September 26, 2019Date of Patent: August 16, 2022Assignee: FUJIFILM CorporationInventors: Noriyuki Kasagi, Naoki Yamada, Mikinaga Mori, Takayuki Kato, Takayuki Kobayashi
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Patent number: 11255849Abstract: An object of the present invention is to provide a kit in which a quantitative determination of a substance to be measured in a biological sample can be carried out with high accuracy, even in a case where the substance to be measured includes a plurality of substances having different structures.Type: GrantFiled: August 29, 2018Date of Patent: February 22, 2022Assignee: FUJIFILM CorporationInventors: Hiroyuki Chiku, Noriyuki Kasagi
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Publication number: 20210038518Abstract: An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.Type: ApplicationFiled: October 26, 2020Publication date: February 11, 2021Applicant: FUJIFILM CorporationInventors: Noriyuki KASAGI, Naoki YAMADA, Mikinaga MORI, Takayuki KATO, Takayuki KOBAYASHI
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Patent number: 10883986Abstract: An object of the present invention is to provide a kit for quantitatively determining a bile acid, in which it is possible to improve measurement accuracy by sufficiently dissociating the bile acid from a polymer component, and to rapidly carry out the quantitative determination of the bile acid with high accuracy under various environments, and a method for quantitatively determining the bile acid. According to the present invention, a kit for quantitatively determining a bile acid in a biological sample, including a compound represented by General Formula (I) defined in the present specification in a dry state; a fluorescent particle that has a first binding substance capable of binding to the bile acid; and a substrate that has a detection region having a second binding substance capable of binding to any one of the bile acid and the first binding substance, is provided.Type: GrantFiled: August 29, 2018Date of Patent: January 5, 2021Assignee: FUJIFILM CorporationInventors: Noriyuki Kasagi, Hiroyuki Chiku, Ayumi Era
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Patent number: 10816469Abstract: An object of the present invention is to provide a kit and a method by which a quantitative determination of a substance to be measured in a biological sample can be carried out with high accuracy while avoiding the influence of an antibody such as an anti-serum albumin antibody present in blood. According to the present invention, a kit for quantitatively determining a substance to be measured in a biological sample, the kit including: a labeled particle that has a first binding substance capable of binding to the substance to be measured, and a first blocking agent; and a substrate that has a detection region having a second binding substance capable of binding to any one of the substance to be measured and the first binding substance, and a second blocking agent, in which the first blocking agent and the second blocking agent are different from each other, is provided.Type: GrantFiled: August 29, 2018Date of Patent: October 27, 2020Assignee: FUJIFILM CorporationInventors: Noriyuki Kasagi, Hiroyuki Chiku
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Publication number: 20200016079Abstract: An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.Type: ApplicationFiled: September 26, 2019Publication date: January 16, 2020Applicant: FUJIFILM CorporationInventors: Noriyuki KASAGI, Naoki YAMADA, Mikinaga MORI, Takayuki KATO, Takayuki KOBAYASHI
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Publication number: 20180372638Abstract: An object of the present invention is to provide a kit and a method by which a quantitative determination of a substance to be measured in a biological sample can be carried out with high accuracy while avoiding the influence of an antibody such as an anti-serum albumin antibody present in blood. According to the present invention, a kit for quantitatively determining a substance to be measured in a biological sample, the kit including: a labeled particle that has a first binding substance capable of binding to the substance to be measured, and a first blocking agent; and a substrate that has a detection region having a second binding substance capable of binding to any one of the substance to be measured and the first binding substance, and a second blocking agent, in which the first blocking agent and the second blocking agent are different from each other, is provided.Type: ApplicationFiled: August 29, 2018Publication date: December 27, 2018Applicant: FUJIFILM CorporationInventors: Noriyuki KASAGI, Hiroyuki CHIKU
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Publication number: 20180372731Abstract: An object of the present invention is to provide a kit in which a quantitative determination of a substance to be measured in a biological sample can be carried out with high accuracy, even in a case where the substance to be measured includes a plurality of substances having different structures.Type: ApplicationFiled: August 29, 2018Publication date: December 27, 2018Applicant: FUJIFILM CorporationInventors: Hiroyuki CHIKU, Noriyuki KASAGI
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Publication number: 20180372737Abstract: An object of the present invention is to provide a kit for quantitatively determining a bile acid, in which it is possible to improve measurement accuracy by sufficiently dissociating the bile acid from a polymer component, and to rapidly carry out the quantitative determination of the bile acid with high accuracy under various environments, and a method for quantitatively determining the bile acid. According to the present invention, a kit for quantitatively determining a bile acid in a biological sample, including a compound represented by General Formula (I) defined in the present specification in a dry state; a fluorescent particle that has a first binding substance capable of binding to the bile acid; and a substrate that has a detection region having a second binding substance capable of binding to any one of the bile acid and the first binding substance, is provided.Type: ApplicationFiled: August 29, 2018Publication date: December 27, 2018Applicant: FUJIFILM CorporationInventors: Noriyuki KASAGI, Hiroyuki CHIKU, Ayumi ERA
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Patent number: 10161935Abstract: To provide a test substance measurement method and a test substance measurement kit adapted to improve the accuracy of the measurement of a test substance. A test substance measurement kit includes: fluorescent particles which are modified with a first binding substance having specific bindability to a test substance; non-fluorescent particles which are modified with a second binding substance having no specific bindability to the test substance; and a substrate on which a first metal film to which a third binding substance having specific bindability to the test substance is fixed, and a second metal film to which a fourth binding substance having no bindability to the test substance, but having bindability to the first binding substance is fixed, and which has a smaller thickness than the first metal film are formed.Type: GrantFiled: June 4, 2015Date of Patent: December 25, 2018Assignee: FUJIFILM CorporationInventors: Nobuhiko Fujiwara, Noriyuki Kasagi, Toshihito Kimura, Kazuhiro Nakamura
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Patent number: 9296814Abstract: It is an object of the present invention to provide an antibody that recognizes a canine TSH and binds thereto, without obtaining a large amount of canine TSH antigen. The present invention provides a monoclonal antibody produced by a hybridoma having Accession No. FERM BP-11490.Type: GrantFiled: August 23, 2012Date of Patent: March 29, 2016Assignee: FUJIFILM CorporationInventors: Noriyuki Kasagi, Yuya Watanabe
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Publication number: 20160069909Abstract: The present invention provides a reagent kit which is used for measuring a test substance in a biological sample and can improve measurement sensitivity of the test substance; measurement kit; and a method of measuring the test substance. Provided is a reagent kit which is used for measuring the above-described test substance in the biological sample and contains first particles which are modified by a first binding substance having specific binding properties with respect to the test substance and have a label, and a compound which has at least one amino group having a positive charge.Type: ApplicationFiled: August 31, 2015Publication date: March 10, 2016Applicant: FUJIFILM CORPORATIONInventors: Kazuhiro NAKAMURA, Noriyuki KASAGI, Hiroyuki CHIKU, Kentaro NAKAMURA
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Publication number: 20150355175Abstract: To provide a test substance measurement method and a test substance measurement kit adapted to improve the accuracy of the measurement of a test substance. A test substance measurement kit includes: fluorescent particles which are modified with a first binding substance having specific bindability to a test substance; non-fluorescent particles which are modified with a second binding substance having no specific bindability to the test substance; and a substrate on which a first metal film to which a third binding substance having specific bindability to the test substance is fixed, and a second metal film to which a fourth binding substance having no bindability to the test substance, but having bindability to the first binding substance is fixed, and which has a smaller thickness than the first metal film are formed.Type: ApplicationFiled: June 4, 2015Publication date: December 10, 2015Applicant: FUJIFILM CORPORATIONInventors: Nobuhiko FUJIWARA, Noriyuki KASAGI, Toshihito KIMURA, Kazuhiro NAKAMURA
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Patent number: 8912010Abstract: Provided are a base plate and a method for thyroxine immunoassay, which are capable of decreasing the signal change rate caused by temperature change in a high-sensitivity immunoassay method for thyroxine. A base plate for thyroxine immunoassay which has a conjugate of thyroxine or a derivative thereof and albumin immobilized thereon, and in which the ratio of the molecule number of thyroxine or a derivative thereof to the molecule number of albumin in the immobilized conjugate, is disclosed.Type: GrantFiled: September 11, 2012Date of Patent: December 16, 2014Assignee: FUJIFILM CorporationInventors: Noriyuki Kasagi, Junichi Katada, Tadahiro Matsuno
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Publication number: 20140295468Abstract: The test substance assay method includes (i) obtaining a mixed solution by mixing (a) first dry particles that are modified with first binding substances exhibiting binding properties specific to a test substance, have an average particle size of 100 nm to 200 nm, and have labels, and (b) second dry particles that are modified with second binding substances not exhibiting binding properties specific to the test substance, have an average particle size of 100 nm to 200 nm, and do not have labels with (c) a test sample solution containing the test substance; (ii) applying the mixed solution onto a substrate; (iii) causing the test substance to be trapped in a reaction site on the substrate that has third binding substances having binding properties specific to the test substance or has substances exhibiting binding properties to the first binding substances; and (iv) detecting the test substance.Type: ApplicationFiled: March 28, 2014Publication date: October 2, 2014Applicant: FUJIFILM CorporationInventors: Noriyuki KASAGI, Hiroyuki CHIKU, Dai UJIHARA, Toshihide YOSHITANI
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Patent number: 8524864Abstract: It is an object of the present invention to provide a method for producing a conjugate of thyroxine and albumin with higher purity. The present invention provides a method for producing a conjugate of thyroxine and albumin which comprises: step (a) of converting a carboxyl group in thyroxine having a carboxyl group to be linked to albumin into an active ester and allowing the thyroxine to react with albumin, so as to prepare a conjugate of thyroxine and albumin; and step (b) of purifying the conjugate with the use of an acidic mixed aqueous solvent in which the thyroxine having a carboxyl group to be linked to albumin is dissolved but albumin is not precipitated.Type: GrantFiled: August 19, 2011Date of Patent: September 3, 2013Assignee: FUJIFILM CorporationInventors: Noriyuki Kasagi, Tadahiro Matsuno