Abstract: The present invention relates to a permselective separation membrane that can be used in blood purifying treatment. More particularly, the present invention relates to a polysulfone-based permselective separation membrane which has well-balanced separation properties, highly stable safety and performance, and also can be smoothly assembled into a module, and a method for producing the same.

Abstract: The present invention provides a polysulfone type hollow fiber membrane which is reliable in safety and stability of performance and is easily incorporated into a module, and thus can be suitably used in a highly water permeable blood purifier for use in a therapy of chronic renal failure. The present invention relates to a polysulfone type selectively permeable hollow fiber membrane comprising a polysulfone type resin and a hydrophilic polymer as main components, and characterized in that (A) the content of the hydrophilic polymer in the uppermost layer of a surface of the polysulfone type hollow fiber membrane on the blood-contacting side is at least 1.1 times larger than the content of the hydrophilic polymer in the proximate layer of the surface on the blood-contacting side, and (B) the content of the hydrophilic polymer in the uppermost layer of the other surface of the polysulfone type hollow fiber membrane, i.e., the reverse side of the surface on the blood-contacting side, is at least 1.

Abstract: The present invention provides a highly water permeable hollow fiber membrane type blood purifier for medical use, which is excellent in safety and module-assembling ease and which has a high water permeability suitable for use in therapy of chronic renal failure. The present invention relates to a highly water-permeable hollow fiber type blood purifier comprising hydrophobic polymer hollow fiber membranes each of which contains a hydrophilic polymer, characterized in that the amount of the hydrophilic polymer eluted from the hollow fiber membrane is 10 ppm or less; in that the ratio of the hydrophilic polymer in the outer surface of the hollow fiber membrane is 25 to 50 mass %; in that the burst pressure of the hollow fiber membrane is 0.5 MPa or higher; and in that the coefficient of water permeability of the blood purifier is 150 ml/m2/hr./mmHg or higher.

Abstract: The present invention relates to a permselective separation membrane that can be used in blood purifying treatment. More particularly, the present invention relates to a polysulfone-based permselective separation membrane which has well-balanced separation properties, highly stable safety and performance, and also can be smoothly assembled into a module, and a method for producing the same.

Abstract: The present invention relates to a polysulfone permselective hollow fiber membrane bundle which has high safety and high reliability in performance and which is particularly suitable for use in a blood purifier or the like, a process for manufacturing the same, and a blood purifier comprising the same.

Abstract: The present invention provides polysulfone-based hollow fiber membranes having high water permeable performance and for use in therapy of chronic renal failures, said hollow fiber membranes having high safety and high stability in performance and being excellent in module-fabricating workability. The present invention also provides a process for manufacturing the same. The present invention relates to a bundle of a plurality of selectively permeable polysulfone-based hollow fiber membranes wherein the amount of a hydrophilic polymer eluting from each hollow fiber membrane is not larger than 10 ppm, and wherein the content of the hydrophilic polymer in the outer surface of the hollow fiber membrane is 25 to 50 mass %, and this bundle is characterized in that any of extracted solutions from ten fractions of said bundle, obtained by dividing the bundle at substantially regular intervals along the lengthwise direction, shows a maximum value of smaller than 0.

Abstract: The present invention provides a polysulfone type hollow fiber membrane which is reliable in safety and stability of performance and is easily incorporated into a module, and thus can be suitably used in a highly water permeable blood purifier for use in a therapy of chronic renal failure. The present invention relates to a polysulfone type selectively permeable hollow fiber membrane comprising a polysulfone type resin and a hydrophilic polymer as main components, and characterized in that (A) the content of the hydrophilic polymer in the uppermost layer of a surface of the polysulfone type hollow fiber membrane on the blood-contacting side is at least 1.1 times larger than the content of the hydrophilic polymer in the proximate layer of the surface on the blood-contacting side, and (B) the content of the hydrophilic polymer in the uppermost layer of the other surface of the polysulfone type hollow fiber membrane, i.e., the reverse side of the surface on the blood-contacting side, is at least 1.

Abstract: The present invention provides a highly water permeable hollow fiber membrane type blood purifier for medical use, which is excellent in safety and module-assembling ease and which has a high water permeability suitable for use in therapy of chronic renal failure. The present invention relates to a highly water-permeable hollow fiber type blood purifier comprising hydrophobic polymer hollow fiber membranes each of which contains a hydrophilic polymer, characterized in that the amount of the hydrophilic polymer eluted from the hollow fiber membrane is 10 ppm or less; in that the ratio of the hydrophilic polymer in the outer surface of the hollow fiber membrane is 25 to 50 mass %; in that the burst pressure of the hollow fiber membrane is 0.5 MPa or higher; and in that the coefficient of water permeability of the blood purifier is 150 ml/m2/hr./mmHg or higher.